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Allergic Rhinitis and Its Impact on Asthma

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1 Allergic Rhinitis and Its Impact on Asthma
Jean Bousquet, MD, PhD, Paul van Cauwenberge, MD, PhD, Nikolai Khaltaev, MD  Journal of Allergy and Clinical Immunology  Volume 108, Issue 5, Pages S147-S334 (November 2001) DOI: /mai Copyright © 2001 Mosby, Inc. Terms and Conditions

2 Fig. 1 : Prevalence of “hay fever” in year-old children in ISAAC centres. Data from Strachan et al (12). Journal of Allergy and Clinical Immunology  , S147-S334DOI: ( /mai ) Copyright © 2001 Mosby, Inc. Terms and Conditions

3 Fig. 2 : The nasal mucosa. Journal of Allergy and Clinical Immunology  , S147-S334DOI: ( /mai ) Copyright © 2001 Mosby, Inc. Terms and Conditions

4 Fig. 3 : Nasal vasculature.
Journal of Allergy and Clinical Immunology  , S147-S334DOI: ( /mai ) Copyright © 2001 Mosby, Inc. Terms and Conditions

5 Fig. 4 : The role of mast cells in rhinitis. EOS , Eosinophils; MP , macrophages; Ly, lymphocytes. Journal of Allergy and Clinical Immunology  , S147-S334DOI: ( /mai ) Copyright © 2001 Mosby, Inc. Terms and Conditions

6 Fig. 5 : The role of eosinophils in rhinitis. ECP , Eosinophil cationic protein; MBP, major basic protein. Journal of Allergy and Clinical Immunology  , S147-S334DOI: ( /mai ) Copyright © 2001 Mosby, Inc. Terms and Conditions

7 Fig. 6 : The role of Th2 lymphocytes in rhinitis.
Journal of Allergy and Clinical Immunology  , S147-S334DOI: ( /mai ) Copyright © 2001 Mosby, Inc. Terms and Conditions

8 Fig. 7 : Production of leukotrienes. PLA2, Phospholipase A2; 5-LO , 5 lipoxygenase; FLAP , 5LO activating protein. Journal of Allergy and Clinical Immunology  , S147-S334DOI: ( /mai ) Copyright © 2001 Mosby, Inc. Terms and Conditions

9 Fig. 8 : Cell origin of leukotrienes. RBC , Erythrocytes.
Journal of Allergy and Clinical Immunology  , S147-S334DOI: ( /mai ) Copyright © 2001 Mosby, Inc. Terms and Conditions

10 Fig. 9 : The nasal inflammatory response.
Journal of Allergy and Clinical Immunology  , S147-S334DOI: ( /mai ) Copyright © 2001 Mosby, Inc. Terms and Conditions

11 Fig. 10 : Recruitment of cells in the nasal mucosa.
Journal of Allergy and Clinical Immunology  , S147-S334DOI: ( /mai ) Copyright © 2001 Mosby, Inc. Terms and Conditions

12 Fig. 11 : The IgE immune response. TCR , T-cell receptor; MHC , major histocompatibility complex. Journal of Allergy and Clinical Immunology  , S147-S334DOI: ( /mai ) Copyright © 2001 Mosby, Inc. Terms and Conditions

13 Fig. 12 : Symptoms induced by allergen challenge (early and late-phase reaction) and of intermittent and persistent rhinitis. Journal of Allergy and Clinical Immunology  , S147-S334DOI: ( /mai ) Copyright © 2001 Mosby, Inc. Terms and Conditions

14 Fig. 14 : Activation of epithelial cells.
Journal of Allergy and Clinical Immunology  , S147-S334DOI: ( /mai ) Copyright © 2001 Mosby, Inc. Terms and Conditions

15 Fig. 15 : Inflammation in allergic rhinitis.
Journal of Allergy and Clinical Immunology  , S147-S334DOI: ( /mai ) Copyright © 2001 Mosby, Inc. Terms and Conditions

16 Fig. 16 : Similarities and differences between asthma and rhinitis. In rhinitis, there are numerous blood vessels explaining nasal obstruction. In asthma, there is smooth muscle explaining bronchial obstruction. Eos , Eosinophils; Neut , neutrophils; MC , mast cells; Ly , lymphocytes; MP , macrophages. Journal of Allergy and Clinical Immunology  , S147-S334DOI: ( /mai ) Copyright © 2001 Mosby, Inc. Terms and Conditions

17 Fig. 17 : Diagnosis of IgE-mediated allergy.
Journal of Allergy and Clinical Immunology  , S147-S334DOI: ( /mai ) Copyright © 2001 Mosby, Inc. Terms and Conditions


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