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Intracellular Transport Pathways

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Presentation on theme: "Intracellular Transport Pathways"— Presentation transcript:

1 Intracellular Transport Pathways

2 Three major coats function in the secretory pathway

3 Intracellular Transport Pathways
AP2 AP1, 3

4 Composition of the COPII coat

5 Structure of Sec13/31 cage Stagg et al. Nature 2006

6 COPI coat assembly

7 COPI-coated vesicles

8 Clathrin-coated vesicles

9 Clathrin-coated vesicles

10 Clathrin-coated vesicles

11 Endocytosis requires dynamin GTPase

12 Dynamin forms a neck

13 - Priming: Recruitment of GTP-binding protein GEF localization! - Coat recruitment - Cargo recruitment interactions with coat components fusion machinery components

14 SNARE Hypothesis v- and t-SNAREs are part of the fusion machinery
v- and t-SNAREs provide compartment specificity

15

16 “SNAREpin model

17 HA-induced membrane fusion

18 SNARE-mediated fusion

19 SNARE-mediated fusion

20 v/t SNARE fusion cycle

21 v/t SNAREs are compartment-specific
From McNew et al. (2000)

22 v/t SNAREs are compartment-specific
From Parlati et al. (2000)

23 compartment-specific
v/t SNAREs are compartment-specific From Parlati et al. (2000)

24 v/t SNAREs are compartment-specific
Parlati et al. (2000)

25 Flipped SNAREs can fuse cells
Hu et al., Science 2003


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