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Figure 5 Inter-relationships between sleep apnoea, CKD and brain injury Figure 5 | Inter-relationships between sleep apnoea, CKD and brain injury. In chronic.

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Presentation on theme: "Figure 5 Inter-relationships between sleep apnoea, CKD and brain injury Figure 5 | Inter-relationships between sleep apnoea, CKD and brain injury. In chronic."— Presentation transcript:

1 Figure 5 Inter-relationships between sleep apnoea, CKD and brain injury
Figure 5 | Inter-relationships between sleep apnoea, CKD and brain injury. In chronic kidney disease (CKD), sleep apnoea is triggered by mechanisms initiated in the central nervous system and by fluid retention leading to pharyngeal narrowing and airway obstruction. Conversely, sleep apnoea can cause CKD via hypoxia and inflammation. Sleep apnoea has major detrimental effects on the cardiovascular system via the development of hypertension, high sympathetic activity, activation of the RAS and aldosterone, insulin resistance, endothelial dysfunction and inflammation. RAS, renin–angiotensin system; SNS, sympathetic nervous system. Zoccali, C. et al. (2017) The systemic nature of CKD Nat. Rev. Nephrol. doi: /nrneph

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