1. NERVOUS SYSTEM DISEASES
CHAPTER 24

2. Anatomy Review
Central Nervous System
Peripheral Nervous System

3. CNS Features
Meninges - membranes surrounding brain tissue-Dura mater, Pia mater, arachnoid mater, doesit mater
Blood Brain Barrier- tight junctions between endothelial cells in CNS vessels prevent

4. Bacterial Diseases
Bacterial meningitis most commonly caused by one of three types of bacteria: Haemophilus influenzae type b, Neisseria meningitidis (meningococcus), and Streptococcus pneumoniae bacteria
Brain Abscesses

5. Viral Diseases
Viral meningitis
enteroviruses
Rabies
Lyssavirus genus

6. Rabies Statistics

7. Rabies Statistics

8. Viral Diseases (cont.) Viral Encephalitis Herpes Meningoencephalitis
inflammation of the brain parenchyma,
Herpes Meningoencephalitis

9. Viral Diseases (cont.)
West Nile Fever

10. West Nile Virus
WNV has three different effects on humans. The first is an asymptomatic infection; the second is a mild febrile syndrome termed West Nile Fever; the third is a neuroinvasive disease termed West Nile meningitis or encephalitis. The population proportion of these three states is roughly 110:30:1

11. Bacterial Nerve Diseases
Hansen’s Disease

12. Bacterial Nerve Diseases
Tetanus
Botulism
“lockjaw
Clostridium tetani
Blocks acetocholine release

13. Viral Nerve Diseases — Polio
Poliovirus (poliomyelitis)
preferentially infecting and destroying motor neurons

14. Prion Diseases
Mad Cow Disease
Kuru

15. Prion Diseases
Creutzfeld Jacob Variant Disease

16. Parasitic Disease
African Sleeping Sickness
Chaga’s Disease