1. © 2013 Pearson Education, Inc. Chapter 22: Microbial Diseases of the Nervous System $100 $200 $300 $400 $500 $100$100$100 $200 $300 $400 $500 The Nervous System Bacterial Diseases Fungal and Protozoan Diseases Prion Diseases Viral Diseases FINAL ROUND

2. © 2013 Pearson Education, Inc. Topic 1: The Nervous System $100 Question In the brain, cerebrospinal fluid flows through the a.subdural space. b.subarachnoid space. c.arachnoid mater. d.pia mater. ANSWER BACK TO GAME

3. © 2013 Pearson Education, Inc. Topic 1: The Nervous System $100 Answer In the brain, cerebrospinal fluid flows through the a.subdural space. b.subarachnoid space. c.arachnoid mater. d.pia mater. BACK TO GAME

4. © 2013 Pearson Education, Inc. Topic 1: The Nervous System $200 Question What is the order of the layer of meninges from the innermost to the outermost? a.arachnoid mater, dura mater, pia mater b.dura mater, arachnoid mater, pia mater c.pia mater, dura mater, arachnoid mater d.pia mater, arachnoid mater, dura mater BACK TO GAME ANSWER

5. © 2013 Pearson Education, Inc. Topic 1: The Nervous System $200 Answer What is the order of the layer of meninges from the innermost to the outermost? a.arachnoid mater, dura mater, pia mater b.dura mater, arachnoid mater, pia mater c.pia mater, dura mater, arachnoid mater d.pia mater, arachnoid mater, dura mater BACK TO GAME

6. © 2013 Pearson Education, Inc. Topic 1: The Nervous System $300 Question Inflammation of the brain is called a.meningitis. b.encephalitis. c.neuritis. d.hydrocephalus. BACK TO GAME ANSWER

7. © 2013 Pearson Education, Inc. Topic 1: The Nervous System $300 Answer Inflammation of the brain is called a.meningitis. b.encephalitis. c.neuritis. d.hydrocephalus. BACK TO GAME

8. © 2013 Pearson Education, Inc. Topic 1: The Nervous System $400 Question Drugs can cross the blood–brain barrier ONLY if they are a.large-molecular-weight molecules. b.small-molecular-weight molecules. c.water-soluble. d.lipid-soluble. BACK TO GAME ANSWER

9. © 2013 Pearson Education, Inc. Topic 1: The Nervous System $400 Answer BACK TO GAME Drugs can cross the blood–brain barrier ONLY if they are a.large-molecular-weight molecules. b.small-molecular-weight molecules. c.water-soluble. d.lipid-soluble.

10. © 2013 Pearson Education, Inc. Topic 1: The Nervous System $500 Question Bacteria can grow well in cerebrospinal fluid because it has low levels of circulating antibodies and a.water. b.glucose. c.complement. d.sodium. BACK TO GAME ANSWER

11. © 2013 Pearson Education, Inc. Topic 1: The Nervous System $500 Answer BACK TO GAME Bacteria can grow well in cerebrospinal fluid because it has low levels of circulating antibodies and a.water. b.glucose. c.complement. d.sodium.

12. © 2013 Pearson Education, Inc. Topic 2: Bacterial Diseases $100 Question In adult patients, about 80% of the cases of bacterial meningitis are now caused by Neisseria meningitidis and a. Haemophilus influenzae type B. b. Streptococcus pneumoniae. c. Listeria monocytogenes. d. Clostridium tetani. BACK TO GAME ANSWER

13. © 2013 Pearson Education, Inc. Topic 2: Bacterial Diseases $100 Answer In adult patients, about 80% of the cases of bacterial meningitis are now caused by Neisseria meningitidis and a. Haemophilus influenzae type B. b. Streptococcus pneumoniae. c. Listeria monocytogenes. d. Clostridium tetani. BACK TO GAME

14. © 2013 Pearson Education, Inc. Topic 2: Bacterial Diseases $200 Question The manifestations of tetanus are due to a.neurotoxin. b.leukocidins. c.hemolysins. d.coagulase. BACK TO GAME ANSWER

15. © 2013 Pearson Education, Inc. Topic 2: Bacterial Diseases $200 Answer The manifestations of tetanus are due to a.neurotoxin. b.leukocidins. c.hemolysins. d.coagulase. BACK TO GAME

16. © 2013 Pearson Education, Inc. Topic 2: Bacterial Diseases $300 Question Which gram-positive rod is known to cause stillbirth and neurological disease in animals? a. Listeria monocytogenes b. Streptococcus pneumoniae c. Clostridium botulinum d. Haemophilus influenzae BACK TO GAME ANSWER

17. © 2013 Pearson Education, Inc. Topic 2: Bacterial Diseases $300 Answer Which gram-positive rod is known to cause stillbirth and neurological disease in animals? a. Listeria monocytogenes b. Streptococcus pneumoniae c. Clostridium botulinum d. Haemophilus influenzae BACK TO GAME

18. © 2013 Pearson Education, Inc. Topic 2: Bacterial Diseases $400 Question BACK TO GAME ANSWER A polysaccharide vaccine that can be much improved by conjugation with protein carriers exists against which form of bacterial meningitis? a. Haemophilus influenzae b. pneumococcal c. meningococcal d. Listeria monocytogenes

19. © 2013 Pearson Education, Inc. Topic 2: Bacterial Diseases $400 Answer BACK TO GAME A polysaccharide vaccine that can be much improved by conjugation with protein carriers exists against which form of bacterial meningitis? a. Haemophilus influenzae b. pneumococcal c. meningococcal d. Listeria monocytogenes

20. © 2013 Pearson Education, Inc. Topic 2: Bacterial Diseases $500 Question Which of the following statements about Mycobacterium leprae is FALSE? a.Patients must be put into isolation. b.Patients transmit the disease directly. c.Patients rarely die of the disease. d.A skin biopsy sample can be used for diagnosis. BACK TO GAME ANSWER

21. © 2013 Pearson Education, Inc. Topic 2: Bacterial Diseases $500 Answer Which of the following statements about Mycobacterium leprae is FALSE? a.Patients must be put into isolation. b.Patients transmit the disease directly. c.Patients rarely die of the disease. d.A skin biopsy sample can be used for diagnosis. BACK TO GAME

22. © 2013 Pearson Education, Inc. Topic 3: Fungal and Protozoan Diseases $100 Question Trypanosoma brucei is transmitted by a.tsetse flies. b.body lice. c.houseflies. d.head lice. BACK TO GAME ANSWER

23. © 2013 Pearson Education, Inc. Topic 3: Fungal and Protozoan Diseases $100 Answer Trypanosoma brucei is transmitted by a.tsetse flies. b.body lice. c.houseflies. d.head lice. BACK TO GAME

24. © 2013 Pearson Education, Inc. Topic 3: Fungal and Protozoan Diseases $200 Question Which etiological agent that causes meningitis produces an extremely heavy (thick) polysaccharide capsule? a. Haemophilus influenzae b. Streptococcus pneumoniae c. Listeria monocytogenes d. Cryptococcus neoformans BACK TO GAME ANSWER

25. © 2013 Pearson Education, Inc. Topic 3: Fungal and Protozoan Diseases $200 Answer Which etiological agent that causes meningitis produces an extremely heavy (thick) polysaccharide capsule? a. Haemophilus influenzae b. Streptococcus pneumoniae c. Listeria monocytogenes d. Cryptococcus neoformans BACK TO GAME

26. © 2013 Pearson Education, Inc. Topic 3: Fungal and Protozoan Diseases $300 Question Which of the following patients are the most susceptible to fungal infections? a.elderly patients b.infants c.immunocompromised patients d.cardiac patients BACK TO GAME ANSWER

27. © 2013 Pearson Education, Inc. Topic 3: Fungal and Protozoan Diseases $300 Answer Which of the following patients are the most susceptible to fungal infections? a.elderly patients b.infants c.immunocompromised patients d.cardiac patients BACK TO GAME

28. © 2013 Pearson Education, Inc. Topic 3: Fungal and Protozoan Diseases $400 Question Which etiological agent has a mortality rate near 100%, with death occurring within a few days, after symptoms appear? a. Cryptococcus neoformans b. Acanthamoeba c. Naegleria fowleri d. Trypanosoma brucei BACK TO GAME ANSWER

29. © 2013 Pearson Education, Inc. Topic 3: Fungal and Protozoan Diseases $400 Answer BACK TO GAME Which etiological agent has a mortality rate near 100%, with death occurring within a few days, after symptoms appear? a. Cryptococcus neoformans b. Acanthamoeba c. Naegleria fowleri d. Trypanosoma brucei

30. © 2013 Pearson Education, Inc. Topic 3: Fungal and Protozoan Diseases $500 Question Granulomatous amebic encephalitis is caused by a. Balamuthia mandrillaris. b. Naegleria fowleri. c. Trypansoma brucei. d. Cryptococcus neoformans. BACK TO GAME ANSWER

31. © 2013 Pearson Education, Inc. Topic 3: Fungal and Protozoan Diseases $500 Answer Granulomatous amebic encephalitis is caused by a. Balamuthia mandrillaris. b. Naegleria fowleri. c. Trypansoma brucei. d. Cryptococcus neoformans. BACK TO GAME

32. © 2013 Pearson Education, Inc. Topic 4: Prion Diseases $100 Question Which of the following diseases is caused by a prion? a.rabies b.Creutzfeldt-Jakob disease c.polio d.wound botulism BACK TO GAME ANSWER

33. © 2013 Pearson Education, Inc. Topic 4: Prion Diseases $100 Answer Which of the following diseases is caused by a prion? a.rabies b.Creutzfeldt-Jakob disease c.polio d.wound botulism BACK TO GAME

34. © 2013 Pearson Education, Inc. Topic 4: Prion Diseases $200 Question A prion is a(n) a.abnormally folded protein. b.protein subunit. c.form of a bacterium. d.viral particle. ANSWER BACK TO GAME

35. © 2013 Pearson Education, Inc. Topic 4: Prion Diseases $200 Answer BACK TO GAME A prion is a(n) a.abnormally folded protein. b.protein subunit. c.form of a bacterium. d.viral particle.

36. © 2013 Pearson Education, Inc. Topic 4: Prion Diseases $300 Question Which animal disease is similar to Creutzfeldt- Jacob disease? a.anthrax b.sheep scrapie c.kuru d.transmissible spongiform encephalopathy BACK TO GAME ANSWER

37. © 2013 Pearson Education, Inc. Topic 4: Prion Diseases $300 Answer Which animal disease is similar to Creutzfeldt- Jacob disease? a.anthrax b.sheep scrapie c.kuru d.transmissible spongiform encephalopathy BACK TO GAME

38. © 2013 Pearson Education, Inc. Topic 4: Prion Diseases $400 Question One hypothesis of the origin of mad cow disease in cattle is a.cattle feed contaminated with scrapie. b.direct contact with animals infected with scrapie. c.direct contact with other infected species. d.hormones in cattle feed. BACK TO GAME ANSWER

39. © 2013 Pearson Education, Inc. Topic 4: Prion Diseases $400 Answer BACK TO GAME One hypothesis of the origin of mad cow disease in cattle is a.cattle feed contaminated with scrapie. b.direct contact with animals infected with scrapie. c.direct contact with other infected species. d.hormones in cattle feed.

40. © 2013 Pearson Education, Inc. Topic 4: Prion Diseases $500 Question What conditions does the WHO recommend to sterilize reusable instruments that might have been exposed to prions? a.strong solution of sulfuric acid with autoclaving at 134°C b.strong solution of sodium hydroxide with autoclaving at 115°C c.strong solution of sulfuric acid with extended autoclaving at 115°C d.strong solution of sodium hydroxide with extended autoclaving at 134°C BACK TO GAME ANSWER

41. © 2013 Pearson Education, Inc. Topic 4: Prion Diseases $500 Answer What conditions does the WHO recommend to sterilize reusable instruments that might have been exposed to prions? a.strong solution of sulfuric acid with autoclaving at 134°C b.strong solution of sodium hydroxide with autoclaving at 115°C c.strong solution of sulfuric acid with extended autoclaving at 115°C d.strong solution of sodium hydroxide with extended autoclaving at 134°C BACK TO GAME

42. © 2013 Pearson Education, Inc. Topic 5: Viral Diseases $100 Question Which disease has an incubation period that is usually long enough to allow immunity to develop from postexposure vaccination? a.polio b.rabies c.Hansen’s disease d.arboviral encephalitis BACK TO GAME ANSWER

43. © 2013 Pearson Education, Inc. Topic 5: Viral Diseases $100 Answer Which disease has an incubation period that is usually long enough to allow immunity to develop from postexposure vaccination? a.polio b.rabies c.Hansen’s disease d.arboviral encephalitis BACK TO GAME

44. © 2013 Pearson Education, Inc. Topic 5: Viral Diseases $200 Question A vaccine against which disease occasionally reverts to a virulent form and causes disease? a.rabies b.Japanese encephalitis c.West Nile encephalitis d.polio BACK TO GAME ANSWER

45. © 2013 Pearson Education, Inc. Topic 5: Viral Diseases $200 Answer A vaccine against which disease occasionally reverts to a virulent form and causes disease? a.rabies b.Japanese encephalitis c.West Nile encephalitis d.polio BACK TO GAME

46. © 2013 Pearson Education, Inc. Topic 5: Viral Diseases $300 Question A misdiagnosis of Guillain-Barré syndrome is often given to patients with a.arboviral encephalitis. b.furious rabies. c.polio. d.paralytic rabies. BACK TO GAME ANSWER

47. © 2013 Pearson Education, Inc. Topic 5: Viral Diseases $300 Answer BACK TO GAME A misdiagnosis of Guillain-Barré syndrome is often given to patients with a.arboviral encephalitis. b.furious rabies. c.polio. d.paralytic rabies.

48. © 2013 Pearson Education, Inc. Topic 5: Viral Diseases $400 Question Eastern equine encephalitis has a mortality rate of _____ or more. a.20% b.50% c.30% d.70% BACK TO GAME ANSWER

49. © 2013 Pearson Education, Inc. Topic 5: Viral Diseases $400 Answer Eastern equine encephalitis has a mortality rate of _____ or more. a.20% b.50% c.30% d.70% BACK TO GAME

50. © 2013 Pearson Education, Inc. Topic 5: Viral Diseases $500 Question Arboviral encephalitis is usually diagnosed by a.agglutination tests. b.ELISA tests. c.Gram stain. d.titer. BACK TO GAME ANSWER

51. © 2013 Pearson Education, Inc. Topic 5: Viral Diseases $500 Answer Arboviral encephalitis is usually diagnosed by a.agglutination tests. b.ELISA tests. c.Gram stain. d.titer. BACK TO GAME

52. © 2013 Pearson Education, Inc. FINAL ROUND Question The tetanus vaccine is a(n) a.conjugated vaccine. b.toxoid. c.attenuated whole-agent vaccine. d.inactivated whole-agent vaccine. BACK TO GAME ANSWER

53. © 2013 Pearson Education, Inc. FINAL ROUND Answer The tetanus vaccine is a(n) a.conjugated vaccine. b.toxoid. c.attenuated whole-agent vaccine. d.inactivated whole-agent vaccine. BACK TO GAME