1. breast cancer 2, early onsetpro What does this protein make up or do?
Chapter 13: Chromosome 13
DNA Sequence
Chromosome
84,193
Name of Protein 13
Name of Gene
breast cancer 2, early onsetpro
BRCA2
transcription
Amino acid sequence
mRNA
translation
Cytoplasm
A Cell
Nucleus
What does this protein make up or do?
may cause increased pressure in the eye by obstructing the aqueous outflow
Condition/Disease
Glaucoma

2. Description of BRCA2 Symptoms and characteristics
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of

3. Description of BRCA2.
Who is affected? Anyone, but the following have a higher risk:
Lung cancer causes over 1 million deaths each year worldwide1. Although primarily caused by tobacco smoking, studies have also implicated inherited genetic factors in the etiology of lung cancer; notably, genome-wide association studies (GWAS) in Europeans have consistently identified polymorphic variation at 15q25.1

4. References http://www.nature.com/ng/journal/v46/n7/full/ng.3002.html.