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Chronic caregiver stress and IgE expression, allergen-induced proliferation, and cytokine profiles in a birth cohort predisposed to atopy  Rosalind J.

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Presentation on theme: "Chronic caregiver stress and IgE expression, allergen-induced proliferation, and cytokine profiles in a birth cohort predisposed to atopy  Rosalind J."— Presentation transcript:

1 Chronic caregiver stress and IgE expression, allergen-induced proliferation, and cytokine profiles in a birth cohort predisposed to atopy  Rosalind J. Wright, MD, MPH, Patricia Finn, MD, Johanna Paola Contreras, MD, Sheldon Cohen, PhD, Robert O. Wright, MD, MPH, John Staudenmayer, PhD, Matthew Wand, PhD, David Perkins, MD, PhD, Scott T. Weiss, MD, MS, Diane R. Gold, MD, MPH  Journal of Allergy and Clinical Immunology  Volume 113, Issue 6, Pages (June 2004) DOI: /j.jaci Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions

2 Fig 1 Plots derived from the linear mixed model formulation of penalized splines with family-specific random intercepts included in the model to allow for within-family correlation of repeated stress measurement. Analysis controls for race, active maternal asthma, and cold status. Proliferation was quantified by the SI, which was defined as the mean thymidine incorporation of the stimulated sample divided by that of the unstimulated sample. The SI was considered to be a binary variable indexed as a high (SI >3) or low (SI ≤3) response. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions

3 Fig 2 Modified box plots representing the distribution of TNF-α and IFN-γ expression in supernatants taken from allergen-stimulated (dust mite [Der f 1] and cockroach [Bla g]) and mitogen-stimulated (PHA) PBMCs stratified by caregiver stress levels. Stress was categorized as greater than (High) or less than (Low) the study population median averaged over the first 2 years of the child's life. The upper and lower bounds on the boxes represent the first and third quartiles (25th and 75th percentile of the sample, respectively), the line within the box denotes the median, the whiskers represent values within 1.5 × quartile 3 (top) or quartile 1 (bottom), and the dots show values outlying this range. The y-axis represents actual values that are log spaced. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions

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