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Neighborhood differences in exposure and sensitization to cockroach, mouse, dust mite, cat, and dog allergens in New York City  Omar Olmedo, BS, Inge.

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Presentation on theme: "Neighborhood differences in exposure and sensitization to cockroach, mouse, dust mite, cat, and dog allergens in New York City  Omar Olmedo, BS, Inge."— Presentation transcript:

1 Neighborhood differences in exposure and sensitization to cockroach, mouse, dust mite, cat, and dog allergens in New York City  Omar Olmedo, BS, Inge F. Goldstein, DrPH, Luis Acosta, MD, Adnan Divjan, Andrew G. Rundle, DrPH, Ginger L. Chew, ScD, Robert B. Mellins, MD, Lori Hoepner, MPH, Howard Andrews, PhD, Sara Lopez-Pintado, PhD, James W. Quinn, MA, Frederica P. Perera, DrPH, Rachel L. Miller, MD, Judith S. Jacobson, DrPH, Matthew S. Perzanowski, PhD  Journal of Allergy and Clinical Immunology  Volume 128, Issue 2, Pages e7 (August 2011) DOI: /j.jaci Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Hypothesized mechanism of association between features of neighborhood and asthma prevalence through allergen exposure. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Location of study participants. Each dot represents a study subject’s home and is color-coded according to whether the subject has been classified as living in a LAPN (blue) or a HAPN (red). Neighborhoods are color-coded according to the legend by NYC DOHMH–reported asthma prevalence among 5-year-old children in 2000. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Cockroach (A), mouse (B), dust mite (C), cat (D), and dog (E) allergen in the child’s bed dust by neighborhood asthma prevalence. Lines represent natural spline linear models smoothed with 3 degrees of freedom with 95% CIs (gray). For D and E, full circles represent homes with cat or dogs, respectively, and empty circles represent those without. Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Probability of sensitization to cockroach (A), mouse (B), dust mite (C), cat (D), and dog (E) allergens with exposure to the relevant major allergen. Points represent allergen concentration in the bed dust on the x-axis and the absence (0) or presence (1) of IgE ≥0.35 IU/mL to the relevant allergen on the y-axis. Lines represent logistic regression models with 95% CIs (gray). Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig E1 Probability of sensitization to cockroach (A), mouse (B), dust mite (C), cat (D), and dog (E) allergens with exposure to the relevant major allergen. Points represent allergen concentration in the bed dust on the x-axis and the absence (0) or presence (1) of IgE ≥1.0 IU/mL to the relevant allergen on the y-axis. Lines represent logistic regression models with 95% CIs (gray). Journal of Allergy and Clinical Immunology  , e7DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions


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