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Effect of γ-aminobutyric acid and nattokinase-enriched fermented beans on the blood pressure of spontaneously hypertensive and normotensive Wistar–Kyoto rats Kanintra Suwanmanon, Pao-Chuan Hsieh Journal of Food and Drug Analysis Volume 22, Issue 4, Pages (December 2014) DOI: /j.jfda Copyright © Terms and Conditions
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Fig. 1 Concentration of serum cation of spontaneously hypertensive rats (SHR) after different treatments. Values are the means with standard errors for six animals per group. aNo significant difference was observed in each group (p < 0.05). Journal of Food and Drug Analysis , DOI: ( /j.jfda ) Copyright © Terms and Conditions
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Fig. 2 Effect of a single oral administration of γ-aminobutyric acid (GABA) and nattokinase on systolic blood pressure (SBP) values in (A) spontaneously hypertensive rats and (B) Wistar–Kyoto rats. Symbols: ■, SHD; □, SMD; ▲, SLD; ×, SD; ▼, SM; ○, WHD; ●, WD. Values are means with standard errors for six animals per group. Mean values were significantly different from the control value at the same time point: p < 0.05. SD = negative control in the SHR; SHD = high dose of GABA and nattokinase in the SHR; SLD = low dose of GABA and nattokinase in the SHR; SM = medium dose of GABA and nattokinase in the SHR; SMD = medium dose of GABA and nattokinase in the SHR; WD = negative control in the WKY; WHD = high dose of GABA and nattokinase in the WKY. Journal of Food and Drug Analysis , DOI: ( /j.jfda ) Copyright © Terms and Conditions
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Fig. 3 Effect of a single oral administration of GABA and nattokinase on diastolic blood pressure (DBP) values in (A) spontaneously hypertensive rats and (B) Wistar–Kyoto rats. Symbols: ■, SHD; □, SMD; ▲, SLD; ×, SD; ▼, SM; ○, WHD; ●, WD. Values are means with standard errors for six animals per group. Mean values were significantly different from the control value at the same time point: p < 0.05. GABA = γ-aminobutyric acid; SD = negative control in the SHR; SHD = high dose of GABA and nattokinase in the SHR; SLD = low dose of GABA and nattokinase in the SHR; SM = medium dose of GABA and nattokinase in the SHR; SMD = medium dose of GABA and nattokinase in the SHR; WD = negative control in the WKY; WHD = high dose of GABA and nattokinase in the WKY. Journal of Food and Drug Analysis , DOI: ( /j.jfda ) Copyright © Terms and Conditions
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Fig. 4 Effect of a single oral administration of GABA and nattokinase on mean blood pressure (MBP) values in (A) spontaneously hypertensive rats and (B) Wistar–Kyoto rats. Symbols: ■, SHD; □, SMD; ▲, SLD; ×, SD; ▼, SM; ○, WHD; ●, WD. Values are means with standard errors for six animals per group. Mean values were significantly different from the control value at the same time point: p < 0.05. GABA = γ-aminobutyric acid; SD = negative control in the SHR; SHD = high dose of GABA and nattokinase in the SHR; SLD = low dose of GABA and nattokinase in the SHR; SM = medium dose of GABA and nattokinase in the SHR; SMD = medium dose of GABA and nattokinase in the SHR; WD = negative control in the WKY; WHD = high dose of GABA and nattokinase in the WKY. Journal of Food and Drug Analysis , DOI: ( /j.jfda ) Copyright © Terms and Conditions
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