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Prenatal exposure to nicotine modifies kidney weight and blood pressure in genetically susceptible rats: A case of gene-environment interaction  Zdenka.

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Presentation on theme: "Prenatal exposure to nicotine modifies kidney weight and blood pressure in genetically susceptible rats: A case of gene-environment interaction  Zdenka."— Presentation transcript:

1 Prenatal exposure to nicotine modifies kidney weight and blood pressure in genetically susceptible rats: A case of gene-environment interaction  Zdenka Pausová, Tomáš Paus, Lucie Šedová, Julie Bérubé  Kidney International  Volume 64, Issue 3, Pages (September 2003) DOI: /j x Copyright © 2003 International Society of Nephrology Terms and Conditions

2 Figure 1 (A) Systolic and (B) diastolic blood pressure, (C) mean arterial pressure, and (D) heart rate measured by the tail-cuff method in nine-week-old male spontaneously hypertensive rats (SHR) and normotensive Brown Norway (BN) rats exposed to nicotine and saline during intrauterine development. The within-strain effect of nicotine exposure was evaluated by the two-sided t test. Kidney International  , DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions

3 Figure 2 (A) Body weight and relative (B) heart and (C) kidney weights in nine-week-old male normotensive Brown Norway (BN) rats and spontaneously hypertensive rats (SHR) exposed to nicotine and saline during intrauterine development. The within-strain effect of nicotine exposure was evaluated by the two-sided t test. Kidney International  , DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions

4 Figure 3 The (A andB) kidney and (C) liver expression of the insulin-like growth factor (IGF)-1 and IGF receptor (IGFR) genes in nine-week-old male Brown Norway (BN) rats and spontaneously hypertensive rats (SHR) exposed to nicotine and saline during intrauterine development. The within-strain effect of nicotine exposure was evaluated by the two-sided t test. Kidney International  , DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions

5 Figure 4 (A) Glucose and (B andC) lipid metabolism in nine-week-old male Brown Norway (BN) rats and spontaneously hypertensive rats (SHR) exposed to nicotine and saline during intrauterine development. The within-strain effect of nicotine exposure was evaluated by the two-sided t test. Kidney International  , DOI: ( /j x) Copyright © 2003 International Society of Nephrology Terms and Conditions


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