1. Prime™ Joint Support Formula by Isotonix®
How many of you have, or know someone that has, creaky, achy joints? Or a twinge in the knee? Maybe a sharp shooting pain from the shoulder to the elbow. No big deal, right?
Wrong. All too often, we assume joint pain is a normal part of aging and we just have to learn to live with. But nothing could be further from the truth. It's a serious problem, because pain can affect every aspect of your life.
Pain is not only the experience of hurting; it affects how you handle your life, your work, your interactions with family and friends. Chronic joint pain needs attention because it can impact so much of your life.

2. Bone & Joint Health: A Growing Market
Rheumatoid Arthritis - an autoimmune disease that causes inflammation in multiple joints.
Osteoporosis - a condition in which bones lose their strength and are more likely to break, usually following a minor bump or fall.
Osteoarthritis - a condition that affects your joints, causing pain and stiffness. It’s by far the most common form of joint disease, affecting people all over the world and at least 8 million people in the UK.
These are all common bone and joint issues that people often experience.
Sources:
file:///C:/Users/brinkleeb/Downloads/Arthritis%20key%20facts%20(2).PDF

3. Bone and Joint Health: A Growing Market
Each year around a fifth of the population consult their general practitioner (GP) about a musculoskeletal condition. This amounts to over 100,000 consultations a day .
Almost 31 million days of work were lost last year due to back, neck and muscle problems, according to the Office for National Statistics (ONS).
Approximately 160,000 total hip and knee replacement procedures performed each year in the UK.
A total of 8.75 million people, have sought treatment for osteoarthritis.
Sources:
file:///C:/Users/brinkleeb/Downloads/Osteoarthritis%20in%20general%20practice%20%20July%202013%20%20Arthritis%20Research%20UK%20PDF%20421%20MB.pdf

4. Factors that Aid in decreased bone and joint health
Increased Age
Excessive Weight
Genetics
Injury and overuse
Having A very physically demanding occupation
Some factors that put stress on your joints are:
Excess weight. Being obese or overweight puts additional stress on joints, cartilage, and bones, especially those in the knees. It also means you’re less likely to be physically active.
Family history. Genetics may make a person more likely to develop poor joint health. If you have family members with poor joint health, you may be at an increased risk of developing it too.
Occupation. Certain occupations, such as those in construction, agriculture, cleaning, and retail, increase a person’s risk for developing joint discomfort. Their bodies are used more rigorously as part of their job, which means their joints are worked more and likely age faster than people who have a desk job.
Discomfort in the joints is an ongoing issue due to age, activity, weight, and other factors, so I feel this will always be a growing category. Consumers are looking for more natural ways to continue daily life activities more comfortably.
World­wide about 10% of men and 20 percent of women aged over 60 years have joint discomfort, which causes limitation in movement or, in severe cases, prevent one from performing daily activities.
These numbers continue to rise as the world population becomes more overweight and sedentary. And since participation in sports and other activities are often sporadic, stress and injury to joints is inevitable.
Therefore the supplements industry should experience a steady gain in the joint health sector, with a continued interest in new joint health products that are easy to take on a regular basis and that provide measurable benefits to the end consumer.

5. Healthy and Unhealthy Joint structure
Joints are beautifully designed to let you move your body and support your weight as you go through life.
The bones attach to each other at a joint, where strong tissues called tendons and ligaments help connect the bones. On the ends of each bone is a lining of smooth, protective cartilage and soft tissues (synovial membranes) that produce a liquid called synovial fluid.
Thanks to the cartilage and synovial membranes, your bones are cushioned and lubricated so that they will not rub against each other.
(Image)

6. Joint wear & tear
But, as you get older, cartilage starts to deteriorate from normal wear and tear. The body’s natural shock absorbers are wearing out, which means you begin feeling more of the physical toll your body is experiencing. 
You may even notice that some joints have changed shape—especially in your fingers or toes. You may feel stiff in the morning, or have aches and pains in some joints that never bothered you before. The joint may even become sensitive to the touch.
These problems are common in older people. Usually, they are minor annoyances, but sometimes joint discomfort can make it very hard to function, and eventually they may need to have surgery or have the joint replaced.  
(image)

7. Joint Health: Key Ingredients
Glucosamine
Building block of cartilage and joint tissue.
Hyaluronic Acid
Major component of joint synovial and cartilage.
Pycnogenol® (Pine Bark Extract)
Has been shown in studies to support joint comfort

8. What is Glucosamine? Naturally synthesised in the body
As we age we are less likely to produce glucosamine, resulting in cartilage that is less flexible and weak.
Not readily available in from food sources
Natural compound found in healthy cartilage

9. Hyaluronic Acid
Component of synovial fluid and cartilage in joints and is one of the main lubricating components
Present in every tissue of the body
Produced naturally by the body, but naturally diminishes with age which can cause stiff joints
Has been shown to help support and maintain joint health and flexibility
When it starts to diminish, it can contribute to discomfort in joints
It may also enhance synovial fluid production and aid in wound healing
Hyaluronic Acid is present in every tissue of the body.  It’s most concentrated in synovial fluid which bathes the joints, in the vitreous fluid in the eye, and in the skin.  Hyaluronic acid’s water binding capacity is incredible. It can hold 1000 times its own weight in water.

10. Hyaluronic acid injection
Hyaluronic acid injections are one treatment option doctors may offer when a patient is no longer able to control osteoarthritis pain with ibuprofen or other nonsteroidal anti-inflammatory drugs. The treatment regimen for hyaluronic acid usually involves receiving one injection in the affected joint per week for three to five weeks.
As a patient soon learns, though, hyaluronic acid is no quick fix. It takes about five weeks, on average, before a patient experiences the full benefits of hyaluronic acid injections.
By contrast, corticosteroid injections – the other primary treatment choice when NSAIDs aren’t an option – provide significant relief within a few days. However, pain relief from corticosteroids diminishes markedly within a month or so. What’s more, overuse of corticosteroids can have a catabolic effect – that is, it could cause cartilage to break down and deteriorate further.
A Cochrane review found that pain-relieving benefits of hyaluronic acid persist at peak levels for about three months, on average. 
What I’m trying to bring out here, is that although there are effective treatments available to control osteoarthritis pain, anyone with this condition should also be giving their body the fundamental building blocks to support joint health. That is, glucosamine, hyaluronic acid and Pycnogenol for inflammation control.

11. Pycnogenol® (Pine Bark Extract)
Joint health benefits of Pycnogenol® include:
Pycnogenol® is highly bioavailable to the body, making it easily absorbed, according to studies
It is one of the most researched ingredients, with more than 120 studies published in peer-reviwed medical journals
Combats oxidative stress and may help support joint comfort
In various studies, Pycnogenol® French maritime pine bark extract demonstrated its ability to promote joint mobility and flexibility and naturally relieve the aching. It was also shown that after supplementing with Pycnogenol®, joints were more flexible and less medication was required.

12. Prime™ Joint Support Formula by Isotonix®
Studies suggest the ingredients in Prime Joint Support Formula may help support and maintain joint health and flexibility
Ideal for men and women with an active lifestyle and/or aging
This product is vegetarian and gluten-free and contains no added wheat, soy, gluten, artificial flavours, salt, preservatives or milk.
Easy-to-take, great tasting, Isotonic formula for anyone who has difficulty swallowing tablets.
Produced to high GMP (Good Manufacturing Practises) quality standards.
Does not contain MSM or Chondroitin. Chondroitin has poor absorption due to its high molecular weight and has inconclusive research. It takes large quantities of MSM (2-6 grams) daily for effects to become noticeable.

13. Additional ways to support joints:
Maintain a Healthy Weight to Reduce Joint Stress
Exercise to Build Muscles to Support Joints
Protect Joints with Braces and Guards
Eat Right, including calcium, protein, vitamin D and antioxidants
Maintain a healthy weight. It's the best thing you can do to preserve your joints. Keeping your weight down will help reduce the wear and tear on your joints. Weight loss may also help reduce joint discomfort.
Vary your exercise. Working out helps reduce stiffness in the joints. It is recommended to vary your exercise routine -- low- or no-impact aerobic exercises (swimming, walking, or cycling) twice a week, strength exercises (lifting light weights or household items) twice a week, mixed with stretching and relaxation exercises. You want to make sure you are not overworking any one area of your body.
Keep your muscles in mind. Weight training helps strengthen the muscles and ligaments surrounding joints, protecting them from damage. Modify muscle-building moves so they don't strain the joint of the part you're exercising. Some doctors recommend that if you are suffering from joint discomfort, doing seated leg lifts instead of squats and lunges, which can increase pressure on the knee. Sit on a chair with both feet on the floor. Bend your knee and raise your leg so it's parallel to the floor. You can do one leg at a time or both; as the exercise becomes easier, you can add ankle weights to increase the resistance and build even more muscle strength. (CookingLight.com's Personal Coach: Weight training )
Add ice. Icing your joints after exercise can help you manage pain in your joints. Some doctors suggests icing the joints you use during exercise for 10 minutes after the activity.
Eat beneficial foods. Studies show the omega-3 fatty acids found in fish can help with joint discomfort. The best sources are fish such as salmon and tuna. Research shows vitamin D may also help protect your joints, too. Make sure you get 400 to 800 International Units of vitamin D daily; one cup of milk contains 100 IUs, and three ounces of salmon has

14. Show Me the Money– Isotonix® Prime Joint Support Formula
Code: UK13081
UC:
SR: BV: 42
Servings: 45
Gross MONTHLY Profit Per # of Customers Reordering Each Month
In £ (pounds) 10 25 50
100
250
500
1000
1500
3000
Isotonix
Prime Joint
Support Formula
162.50
406.25
812.50
4,062.5
16,250.00
24,375.00
48,750.00
* The income levels mentioned in the following presentation are for illustration purposes only. They are not intended to represent the income of a typical Market UK Independent Distributor, nor are they intended to represent that any given Independent Distributor will earn income in that amount. The success of any Market UK Independent Distributor will depend upon the amount of hard work, talent and ved”. dedication he or she devotes to building his or her Market UK business. Please take note of the UK Trading scheme regulation warning “Do not be misled by claims that high earning can be early achieved. 14

15. Scientific Sources:
Barringer T et al. Potential Benefits on Impairment of Endothelial Function after a High-fat Meal of 4 weeks of Flavonoid Supplementation. Evidence-based Complementary and Alternative Medicine: eCAM. doi: /ecam/nen048: 1-6, 2008.
Belcaro, G., et al. Variations in C-reactive protein, plasma free radicals and fibrinogen values in patients with osteoarthritis treated with Pycnogenol®. Redox Report. 13(6): , 2008.
Blewis, M., et al. A model of synovial fluid lubricant composition in normal and injured joints. European Cells and Materials. 13: 26-39,
Braham, R., et al. The effect of glucosamine supplementation on people experiencing regular knee pain. British Journal of Sports Medicine. 37(1): 45-49, 2003.
Canali, R., et al. The anti-inflammatory pharmacology of Pycnogenol® in humans involves COX-2 and 5-LOX mRNA expression in leukocytes. International Immunopharmacology. 9(10): , 2009.
Cesarone MR et al. Improvement in circulation and in cardiovascular risk factors with a proprietary isotonic bioflavonoid formula OPC-3. Angiology. 59(4):408-14, 2008.
Cesarone MR et al. Accelerated antioxidant bioavailability of OPC-3 bioflavonoids administered as isotonic solution. Phytotherapy Research. 23(6):775-7, 2009.
Chou, M., et al. Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis. Experimental Biology and Medicine. 230(4): , 2005.
Cisár, P., et al. Effect of pine bark extract (Pycnogenol®) on symptoms of knee osteoarthritis. Phytotherapy Research. 22: ,
Farid, R., et al. Pycnogenol® supplementation reduces pain and stiffness and improves physical function in adults with knee osteoarthritis. Nutrition Research. 27: , 2007.
Gaby, A. Natural treatments for osteoarthritis. Alternative Medicine Review. 4(5): , 1999.
Gouze, J., et al. Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1beta. Arthritis Research and Therapy. 8(6): R173
When you have a moment, take the time to read these to learn about the benefits of this great product!

16. Scientific Sources:
Grimm, T., et al. Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol®). Journal of Inflammation. 3: 1-15, 2006.
Hua, J., et al. Inhibitory actions of glucosamine, a therapeutic agent for osteoarthritis, on the functions of neutrophils. Journal of Leukocyte Biology. 71(4): , 2002.
James, C. and Uhl, T. A review of articular cartilage pathology and the use of glucosamine sulfate. Journal of Athletic Training. 36(4): , 2001.
Laurent, T., et al. Functions of hyaluronan. Annals of the Rheumatic Disease. 54(5): , 1995.
Kelly, G. The role of glucosamine sulfate and chondroitin sulfates in the treatment of degenerative joint disease. Alternative Medicine Review. 3(1): 27-39, 1998.
Nakatani, S., et al. Glucosamine regulates differentiation of a chondrogenic cell line, ATDC5. Biological and Pharmaceutical Bulletin. 30(3): , 2007.
Natural Medicines Comprehensive Database- Pycnogenol
NHPD database: Glucosamine HCl June
Poustie, M., et al. N-butyryl glucosamine increases matrix gene expression by chondrocytes. Journal of Pharmacology and Experimental Therapeutics. 311(2): , 2004.
Reginster, J., et al. Current concepts in the therapeutic management of osteoarthritis with glucosamine. Bulletin (Hospital for Joint Disease). 63(1-2): 31-36, 2005.
Reginster, J., et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomized, placebo-controlled clinical trial. Lancet. 357(9252): , 2001.
Richy, F., et al. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Archives of Internal Medicine. 163(13): , 2003.
Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. International Journal of Clinical Pharmacology and Therapeutics. 40(4): , 2002.
Schäfer, A., et al. Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol®). Biomedicine and Pharmacotherapy. 60: 5-9, 2006.

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