1.  Cancer  Compound perturbations  Gene perturbations  Tumor development  Cancer metastasis  Cancer treatments Altered Caspase-8 Expression

2. Nextbio

3. Caspase-8 Quickview Correlation score is computed using rank-based enrichment algorithms

4. Caspase-8 Expression in Tissues and Cell Lines Gene expression level=448±21.7 Median expression across all tissues=495 Gene expression level=2570 Median expression across all cell lines=1320

5. Caspase-8 Expression in Cancers Over 200 Caspase-8 correlated cancer studies found 353 invasive breast cancer samples vs normal breast

6. Caspase-8 Expression and Compounds Perturbation

7. Caspase-8 Expression and Gene Perturbations

8. Oncomine

9. Cancer subtype analysis -- Tumor development --Cancer metastasis --Cancer treatments

10. Disease Summary for CASP8 Threshold (Gene Rank):AllThreshold (Fold Change)2Threshold (P-value):1E-4Data Type:All Cell color is determined by the best gene rank percentile for the analyses within the cell.

11. CASP8 Expression in Chandran Prostate Grouped by Cancer Sample Site Primary Site Metastasis Lymph Node Metastasis Metastasis - Gland Metastasis - Liver Metastasis - Lung

12. CASP8 Expression in Bittner Renal Grouped by Stage Stage 0a (1) Stage I (137) Stage II (22) Stage III (31) Stage IV (20)

13. CASP8 Expression in Neale Multi-cancer Grouped by Cisplatin Response Status Cisplatin Non-responder (9) Cisplatin Responder (6)

16. Browsing Drug Targets

17. Click to see the type of mutants for each target Browsing Mutants of Drug Targets

18. Drug profiling on CW2 cell line Browsing Drug Profiling of Mutant Cell Line

19. Summary Nextbio results show that Caspase-8 expression changes but not much in comparing cancer vs. normal, changes with compound and gene perturbations Oncomine results show that Caspase-8 expression does not change much with tumor development in kidney cancer, does not change much with cancer metastasis in prostate cancer and Caspase-8 expression does not change much between cisplatin responders and non-responders No information about Caspase-8 was found in CancerDR. Instead, we found Caspase-3 has four mutants which have different drug sensitivity/resistance

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21. Example of Using Nextbio Results to Generate Research Hypothesis Gene expression sets from both SM7- and SM6- resistant cells show strong negative correlation with Gene expression set of MLL leukaemia cell line MV4-11 treated with DOT1L inhibitor. Hypothesis: aberrant expression of the gene targeted by inhibition of DOT1L contributes to resistance to SM6 and SM7

22. Caspase-8 Expression in Cancer Metastasis