1. The BioValley cluster in Alsace: your gateway to Europe

2. What is BioValley ? BioValley®, a unique trinational life sciences cluster

3. 350 350 companies (Pharma / biotech) 40.000 40.000 employees (Life Science field) OFFENBURG KONSTANZ What is BioValley ? 4.3 4.3 Millions inhabitants

4. What is Alsace BioValley?

5. What is Alsace Biovalley ? 9 complementary structures … Alsace International ADIRA CAHR ARI CEEI CONECTUS Technopole SEMIA Association pour le développement de la filière Sciences de la vie – Santé en Alsace

6. Non for profit association dedicated to the development of Life Sciences in Alsace  Funded by central and regional government  Coordinator of the Tri-national BioValley cluster  One of the 3 main LifeScience cluster in France  Member of the LifeScience Corridor France What is Alsace Biovalley ?

7. Accelerate the discovery and the development of therapeutic innovations by: 1. Supporting innovative R&D projects 2. Structuring and improving the environment Our mission

8. Accelerate the discovery and the development of therapeutic innovations by: 1. Supporting innovative R&D projects 2. Structuring and improving the environment 3. Fostering the creation of new activities 4. Provide services to members 5. Attracting foreign businesses Our mission

9. 1. Supporting innovative projects 2 priorities: 1.New therapeutic compounds 2. Medical Technologies Figures:

10. 2. Structuring the environment –Fast and easy access to public research opportunities through our unique « one stop shop » : Conectus –A set of high quality technology platforms to provide services to industry (proteomics, DNA chips, Imaging, phenotyping, genetic engineering … ) –Adapted infrastructures and services : Office and lab spaces, Bio-incubators, start-up coaching programs, etc.

11. 2. Structuring the environment All key competencies along the Drug Development value chain

12. 3. Fostering the creation of new activities INCUBATIONPRE-INCUBATIONDETECTIONPOST-INCUBATION 1.Dropplet 2.BiorLink 3.Primabio 4.Biomica 1.Phosylab 2.Koffeeware 3.Agate 4.Phytodia 1.RDC Ther. 2.Urolead 3.Theleme Winner of the Young Innovative Company Creation contrest 1.Admesys 2.Acrylian 3.Digital Trainers 4.Rhenovia 5.Biowind 6.Sextant 7.Ginkgo 8.RB Nano 9.KLC-T 10.Zephir 11.Anvebor 12.Diagalz 13.SIP Com 14.X.techno 15.Decide Med. 16.eNovalys 17.Cell Prothera 18.Ubertone 19.Firalis 20.Clad 21.Green Ing.

13. Partnership Identification Project engineering and financial engineering Shared Business development Scientific and competitive intelligence International development and promotion Communication 4. A comprehensive set of services

14. 1. A gateway to European market Why have so many companies chosen Alsace BioValley?

15. 2+3 international airports: EuroAirport Basel Mulhouse Fribourg and Strasbourg International Airport. Many connections with Paris Frankfurt and Zurich hubs. High speed train links (TGV East European and TGV Rhin-Rhône) : Strasbourg-Paris in 2h20 (1h50 in 2012). The Rhine River: the most important navigable waterway in Europe. 40 hours downstream to Rotterdam from Strasbourg Port and a direct connection to the Danube River. 4 th region in France for rail freight 2 nd in France for broadband coverage A great accessibility

16. Great penetration of the European pharma-biotech market (source AFII) Nb of biotech companies Production of pharmaceuticqal products

17. 2. A world class education and research environment Why have so many companies chosen Alsace BioValley?

18. CHEMISTRY ONCOLOGY, SURGERY & ROBOTICS GENETICS & MOLECULAR BIOLOGY World-class research institutes

19. A rich and structured academic environment

20. 3. A unique service and Business Environment Why have so many companies chosen Alsace BioValley?

21. Milano Paris Strasbourg YIC* Cambridge Dublin 400 Business performance R&D cost 600 800 Basel 200 0 80 100 120 60 40 20 140 0 Skåne Erlang Vienna Copenhagen An attractive set of national financial incentives… *YIC= Young Innovative Company Status

22. RainDance Technologies France RainDance Technologies ISIS (Pr. A. Griffith) France Administrative support …completed by tailored financial engineering Sanofi Aventis Development of new High Throughput screening technology using microfluidic systems Abroad

23. …completed by tailored financial engineering Affiliate Headquarters TotalAffiliateUniversity Total cost of the project470,000 €240,000 €230,000 € Marginal cost for University95,000 € Public funding215,000 €120,000 €95,000 € Net cash required120,000 € 0 € University R&D collaborative program France Administrative support Abroad

24. The Lifescience Corridor France How to increase our visibility at the international level?

25. October 2008 25 Building a healthcare shiled to fight infectious diseases > Diagnostic, vaccines & new therapies, Systems A unique and broad approach throughout the continuum of Cancer > Prevention, diagnostic, treatment Facing the challenges of tomorrow’s healthcare > Bio Pharmaceuticals : from chemistry and genes towards drugs > Medical Technologies : medical and surgical devices, imaging and robotics What is the Lifescience Corridor France ? LFC represents more than 1,200 companies involving > 80,000 jobs

26. October 2008 26 CANCER-BIO-SANTE CLUSTER

27. October 2008 27 Public Healthcare Scope Building a “healthcare shield” to fight human and animal infectious diseases and viral-induced cancers Developing innovative diagnostic, preventive and therapeutic solutions and delivery systems for more responsive & personalized medicine Core Business Targeted Markets Infectious Diseases, Viro-induced Cancers, Auto- immune Diseases, Orphan Diseases and Inflammatory Diseases Stakeholders a BIO CLUSTER led by industrial firms

28. October 2008 28 Alsace Biovalley: triggering Therapeutic Innovations Preclinical experiment Markers Imaging Physics, photonics, NICT… Life Sciences Chemical Sciences Developing New Drugs Innovative tools for medecine Developing Innovative tools for medecine Targeted therapies Therapeutic Innovations combining technologies and Life Sciences

29. October 2008 29  Canada  Lead partner: Alsace BioValley  Ongoing collaboration with CQVB in Quebec  US  Lead partner: Lyon Biopole  M.O.U. with Massachussetts Office of International Trade and Investment (MOITI) and Massachussetts Technology Transfer Centre (MTTC)  Japan  Lead partner: Cancer BioSanté  Collaboration agreement with Kobe-Kansai Coordinated operations in 3 target countries:

30. October 2008 30 Simplified access to:  Technological partnerships  Academic research institutes and Biotech companies  Multiple source of funding  Technology Transfer Opportunities  One stop shopping for all TTOs  Establishment of European subsidiaries  Direct link with Economical development agencies  National and regional financial incentives

31. October 2008 31 A unique pool of potential partners in the French industry

32. Fabien Sebille fabien.sebille@alsace-biovalley.com Tel : +33 (0) 3 90 40 30 00 www.alsace-biovalley.com www.biovalley.comwww.alsace-biovalley.com www.biovalley.com Thank you for your attention