1. Date of download: 5/29/2016 From: The Effect of a Lower Target Blood Pressure on the Progression of Kidney Disease: Long-Term Follow- up of the Modification of Diet in Renal Disease Study Ann Intern Med. 2005;142(5):342-351. doi:10.7326/0003-4819-142-5-200503010-00009 Mean arterial blood pressure during the Modification of Diet in Renal Disease Study (1989 to 1993).The bars extend from the 25th to the 75th percentiles, and the dotted and solid lines connect the medians. F = month of follow-up; n1 = participants in the usual target blood pressure group for whom a blood pressure measurement was available at the indicated follow-up time point; n2 = participants in the low target blood pressure group for whom a blood pressure measurement was available at the indicated follow-up time point; phase V = 9 months after completion of the trial. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

2. Date of download: 5/29/2016 From: The Effect of a Lower Target Blood Pressure on the Progression of Kidney Disease: Long-Term Follow- up of the Modification of Diet in Renal Disease Study Ann Intern Med. 2005;142(5):342-351. doi:10.7326/0003-4819-142-5-200503010-00009 Outcomes during the Modification of Diet in Renal Disease Study (1989 to 1993) and during long-term follow-up (1993 to 2000).*The number of deaths include only those that occurred before kidney failure. †“Alive” refers to participants who did not develop kidney failure or who died during the period of interest. BP = blood pressure. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

3. Date of download: 5/29/2016 From: The Effect of a Lower Target Blood Pressure on the Progression of Kidney Disease: Long-Term Follow- up of the Modification of Diet in Renal Disease Study Ann Intern Med. 2005;142(5):342-351. doi:10.7326/0003-4819-142-5-200503010-00009 Cumulative probability of kidney failure (top) and cumulative probability of the composite of kidney failure or all-cause mortality before kidney failure (bottom).“Low blood pressure” and “usual blood pressure” refer to a target mean arterial pressure of less than 92 mm Hg and less than 107 mm Hg, respectively. Numbers in parentheses are numbers of participants. For the top panel, there were 554 events (unadjusted = 0.0056; adjusted = 0.00003). For the bottom panel, there were 624 events (unadjusted = 0.0502; adjusted = 0.0024). BP = blood pressure. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

4. Date of download: 5/29/2016 From: The Effect of a Lower Target Blood Pressure on the Progression of Kidney Disease: Long-Term Follow- up of the Modification of Diet in Renal Disease Study Ann Intern Med. 2005;142(5):342-351. doi:10.7326/0003-4819-142-5-200503010-00009 Adjusted hazard ratios in the low target blood pressure group and the usual target blood pressure group, by subgroup.The P value for interaction of target blood pressure with proteinuria was 0.09 for kidney failure and 0.08 for the composite outcome. The P value for interaction of target blood pressure with kidney disease diagnosis was 0.97 for kidney failure and 0.94 for the composite outcome. The P values for the interaction of target blood pressure with study (A versus B) were 0.08 for kidney failure and 0.07 for the composite outcome. All analyses are adjusted for the following baseline variables: log urinary protein, log urinary protein × duration of follow-up, polycystic kidney disease, polycystic kidney disease × duration of follow-up, black ethnicity, transferrin level, high-density lipoprotein cholesterol level, mean arterial pressure, glomerular filtration rate, age, and dietary protein group assignment. The analysis is stratified by clinical center and study. The composite outcome is kidney failure or all-cause mortality before kidney failure. The percentages in parentheses are the proportion of patients in each subgroup with kidney failure or the composite outcome. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians