1. Date of download: 5/31/2016 From: Metabolic Risk Factors Worsen Continuously across the Spectrum of Nondiabetic Glucose Tolerance: The Framingham Offspring Study Ann Intern Med. 1998;128(7):524-533. doi:10.7326/0003-4819-128-7-199804010-00002 Distribution of hemoglobin A 1c levels and of the study population by glucose tolerance categories.1cPMean hemoglobin A levels and 95% CIs (error bars) among women (□s and dotted lines) and men (black squares and solid lines) are given for each glucose tolerance category from the lowest quintile (N1) to the highest quintile (N5) of fasting plasma glucose level among participants with normal glucose tolerance, impaired glucose tolerance (IGT), and previously unrecognized diabetes mellitus (DM). The fasting plasma glucose range and number and proportion of men and women in each category are given below the figure. Means are multivariable adjusted. * < 0.001 for trend from the lowest quintile of normal fasting glucose level to impaired glucose tolerance. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

2. Date of download: 5/31/2016 From: Metabolic Risk Factors Worsen Continuously across the Spectrum of Nondiabetic Glucose Tolerance: The Framingham Offspring Study Ann Intern Med. 1998;128(7):524-533. doi:10.7326/0003-4819-128-7-199804010-00002 Distribution of obesity and blood pressure by glucose tolerance category.top lefttop rightbottom leftbottom rightPMean body mass index ( ), waist-to-hip ratio ( ), systolic blood pressure ( ), and diastolic blood pressure ( ) and 95% CIs (error bars) among women (white squares and dotted lines) and men (black squares and solid lines) are given for each glucose tolerance category from the lowest quintile (N1) to the highest quintile (N5) of fasting plasma glucose level among participants with normal glucose tolerance, impaired glucose tolerance (IGT), and previously undiagnosed diabetes mellitus (DM). Means are multi-variable adjusted. * < 0.001 for trend from the lowest quintile of normal fasting glucose level to impaired glucose tolerance. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

3. Date of download: 5/31/2016 From: Metabolic Risk Factors Worsen Continuously across the Spectrum of Nondiabetic Glucose Tolerance: The Framingham Offspring Study Ann Intern Med. 1998;128(7):524-533. doi:10.7326/0003-4819-128-7-199804010-00002 Distribution of insulin and lipid levels by glucose tolerance category.top left and top rightbottom rightbottom leftPPMean fasting and 2-hour post-oral glucose challenge levels of serum insulin ( ), plasma triglyceride ( ), and plasma high-density lipoprotein cholesterol ( ) and 95% CIs (error bars) among women (white squares and dotted lines) and men (black squares and solid lines) are given for each glucose tolerance category from the lowest quintile (N1) to the highest quintile (N5) of fasting plasma glucose level among participants with normal glucose tolerance, impaired glucose tolerance (IGT), and previously undiagnosed diabetes mellitus (DM). Means are multivariable adjusted. * < 0.001; † = 0.003 for trend from the lowest quintile of normal fasting glucose level to impaired glucose tolerance. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

4. Date of download: 5/31/2016 From: Metabolic Risk Factors Worsen Continuously across the Spectrum of Nondiabetic Glucose Tolerance: The Framingham Offspring Study Ann Intern Med. 1998;128(7):524-533. doi:10.7326/0003-4819-128-7-199804010-00002 Distribution of high-density lipoprotein (HDL) cholesterol levels by obesity and glucose tolerance category.leftright22PMean plasma HDL cholesterol levels and 95% CIs (error bars) among female ( ) and male ( ) participants who were obese (body mass index ≥ 27.3 kg/m in women or ≥ 27.8 kg/m in men [black squares and solid lines]), nonobese (white squares and dotted lines), and obese and nonobese combined (slashed squares and dashed lines) in each glucose tolerance category from the lowest quintile (N1) to the highest quintile (N5) of fasting plasma glucose level among participants with normal glucose tolerance, impaired glucose tolerance (IGT), and previously undiagnosed diabetes mellitus (DM). Means are multivariable adjusted. The values indicate the significance of trends from the lowest quintile of normal fasting glucose level to impaired glucose tolerance. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

5. Date of download: 5/31/2016 From: Metabolic Risk Factors Worsen Continuously across the Spectrum of Nondiabetic Glucose Tolerance: The Framingham Offspring Study Ann Intern Med. 1998;128(7):524-533. doi:10.7326/0003-4819-128-7-199804010-00002 Multivariable odds ratios for metabolic risk factors by glucose tolerance category.22PPPOdds ratios and 95% CIs (error bars) for obesity (body mass index ≥ 27.3 kg/m in women or ≥ 27.8 kg/m in men [top left]), elevated waist-to-hip ratio (>0.9 for women and >1.0 for men [top middle]), hypertension (two measurements with diastolic blood pressure > 90 mm Hg, systolic blood pressure > 140 mm Hg, or any use of antihypertensive medication [top right]), low high-density lipoprotein (HDL) cholesterol level ( 200 mg/dL [bottom middle]), and hyperinsulinemia (fasting insulin level > the 90th percentile of its distribution among Framingham Offspring Study participants with normal glucose tolerance [bottom right]) among women (white squares and dotted lines) and men (black squares and solid lines) are shown for each glucose tolerance category from the lowest quintile (N1) to the highest quintile (N5) of fasting plasma glucose level among participants with normal glucose tolerance, impaired glucose tolerance (IGT), and previously undiagnosed diabetes mellitus (DM). Odds ratios are multivariable adjusted. * < 0.001; † = 0.002; * = 0.008 for trend from the lowest quintile of normal fasting glucose level to impaired glucose tolerance. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

6. Date of download: 5/31/2016 From: Metabolic Risk Factors Worsen Continuously across the Spectrum of Nondiabetic Glucose Tolerance: The Framingham Offspring Study Ann Intern Med. 1998;128(7):524-533. doi:10.7326/0003-4819-128-7-199804010-00002 Age-standardized distribution of the metabolic sum by glucose tolerance category.22The proportion of women (W) and men (M) with 2 to 3 (white bars) or 4 to 6 (diagonally striped bars) of the following features: obesity (body mass index ≥ 27.3 kg/m in women or ≥ 27.8 kg/m in men), elevated waist-to-hip ratio (>0.9 for women and >1.0 for men), hypertension (two measurements of diastolic blood pressure > 90 mm Hg, systolic blood pressure > 140 mm Hg, or any use of antihypertensive medication), low high-density lipoprotein cholesterol level ( 200 mg/dL), or hyperinsulinemia (fasting insulin level greater than the 90th percentile of its distribution among Framingham Offspring Study participants with normal glucose tolerance) are displayed for each glucose tolerance category from the lowest quintile (N1) to the highest quintile (N5) of fasting plasma glucose level among participants with normal glucose tolerance, impaired glucose tolerance (IGT), and previously undiagnosed diabetes mellitus (DM). *P< 0.001 for trend from the lowest quintile of normal fasting plasma glucose level to impaired glucose tolerance. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians