1. Date of download: 5/28/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Effect of a Treatment Strategy Consisting of Pravastatin, Vitamin E, and Homocysteine Lowering on Carotid Intima-Media Thickness, Endothelial Function, and Renal Function in Patients With Mild to Moderate Chronic Kidney Disease: Results From the Anti-Oxidant Therapy in Chronic Renal Insufficiency (ATIC) Study Arch Intern Med. 2007;167(12):1262-1270. doi:10.1001/archinte.167.12.1262 Flow of participants through each stage of the study. Figure Legend:

2. Date of download: 5/28/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Effect of a Treatment Strategy Consisting of Pravastatin, Vitamin E, and Homocysteine Lowering on Carotid Intima-Media Thickness, Endothelial Function, and Renal Function in Patients With Mild to Moderate Chronic Kidney Disease: Results From the Anti-Oxidant Therapy in Chronic Renal Insufficiency (ATIC) Study Arch Intern Med. 2007;167(12):1262-1270. doi:10.1001/archinte.167.12.1262 Change in mean (SE) common carotid intima-media thickness (CC-IMT), with the P values for between-group differences. For 0 to 6 months, 6 to 12 months, 12 to 18 months, and 0 to 18 months, P<.001. Error bars indicate SE. Figure Legend:

3. Date of download: 5/28/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Effect of a Treatment Strategy Consisting of Pravastatin, Vitamin E, and Homocysteine Lowering on Carotid Intima-Media Thickness, Endothelial Function, and Renal Function in Patients With Mild to Moderate Chronic Kidney Disease: Results From the Anti-Oxidant Therapy in Chronic Renal Insufficiency (ATIC) Study Arch Intern Med. 2007;167(12):1262-1270. doi:10.1001/archinte.167.12.1262 Change in mean ( SE) brachial artery flow-mediated vasodilatation (BA-FMD), with the P values for between-group differences. For 0 to 6 months, P = 11; for 6 to 12 months, P =.009; and for 12 to 18 months and 0 to 18 months, P =.001. Error bars indicate SE. Figure Legend:

4. Date of download: 5/28/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Effect of a Treatment Strategy Consisting of Pravastatin, Vitamin E, and Homocysteine Lowering on Carotid Intima-Media Thickness, Endothelial Function, and Renal Function in Patients With Mild to Moderate Chronic Kidney Disease: Results From the Anti-Oxidant Therapy in Chronic Renal Insufficiency (ATIC) Study Arch Intern Med. 2007;167(12):1262-1270. doi:10.1001/archinte.167.12.1262 Change in mean (SE) estimated glomerular filtration rate (eGFR) based on the Modification of Diet in Renal Disease formula (milliliters per minutes per 173 m 2, per Levey equation 7), with the P values for between-group differences. For 0 to 6 months, P =.79; for 6 to 12 months, P =.60; for 12 to 18 months, P =.21; for 18 to 24 months, P =.39; and for 0 to 24 months, P =.33. Error bars indicate SE. Figure Legend:

5. Date of download: 5/28/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Effect of a Treatment Strategy Consisting of Pravastatin, Vitamin E, and Homocysteine Lowering on Carotid Intima-Media Thickness, Endothelial Function, and Renal Function in Patients With Mild to Moderate Chronic Kidney Disease: Results From the Anti-Oxidant Therapy in Chronic Renal Insufficiency (ATIC) Study Arch Intern Med. 2007;167(12):1262-1270. doi:10.1001/archinte.167.12.1262 Change in mean (SE) blood pressure, with the P values for between-group differences. Error bars indicate SE. Figure Legend:

6. Date of download: 5/28/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Effect of a Treatment Strategy Consisting of Pravastatin, Vitamin E, and Homocysteine Lowering on Carotid Intima-Media Thickness, Endothelial Function, and Renal Function in Patients With Mild to Moderate Chronic Kidney Disease: Results From the Anti-Oxidant Therapy in Chronic Renal Insufficiency (ATIC) Study Arch Intern Med. 2007;167(12):1262-1270. doi:10.1001/archinte.167.12.1262 Change in mean (SE) log-transformed urinary albumin excretion, with the P values for between-group differences. For 0 to 6 months, P =.03; for 6 to 12 months, P =.02; for 12 to 18 months, P =.03; for 18 to 24 months, P =.06; and for 0 to 24 months, P =.04. Error bars indicate SE. Figure Legend: