MDL Information Systems, Inc. Powering the Process of Invention Donna del Rey Director, Business Planning

Company Overview  MDL is the global leader in discovery informatics – Profitable, growing, and 25 years of experience – ISIS used in virtually every pharmaceutical and chemical company – Core offerings include discovery IT framework, cheminformatics, assay biology, reference data and decision support – More than 1,500 customers – 500 employees globally on 16 sites  250 in R&D – Wholly owned subsidiary of Elsevier, Inc. in the Elsevier Life Sciences division  Help accelerate the discovery of innovative and successful drug candidates by improving the speed and quality of scientist’s decision making

Product Overview A comprehensive collection of databases, reference works, literature links, and essential discovery content The standard applications and technology that provide the basis of discovery informatics solutions An integrated set of applications for managing chemical and biological discovery workflows A suite of tools and applications for decision support, visualization, analysis, and ADME- toxicity assessment

Product Benefits  Discovery Framework – Modern, open platform for integrated Life Science Discovery solutions based on MDL’s chemistry and biology management technology and key industry standards  Discovery Experiment Management – Synchronize workflow and enhance collaboration between chemistry and biology  Discovery Knowledge – Broad, integrated access to critical information from Internal and external sources  Discovery Predictive Science – Enable collaborative assessment throughout the life of a discovery project through statistical analysis, predictive modeling, visualization, and chemically intelligent content

Oracle Features Used Today & How  MDL ISIS database server runs on Oracle 8i or 9i Database – MDL Direct chemical cartridge built on Extensibility Option – Chemical structures stored inside Oracle Database  MDL Core Interface middle tier embeds Oracle 9i Application Server – Oracle Containers for J2EE provides key functionality  Working with Oracle on performance analysis and tuning

Oracle Benefits  Utilizing Oracle technology allows MDL to focus on core competency in Discovery solutions – Oracle Database is the de facto standard data repository in Life Sciences Discovery  Oracle’s focus on Life Sciences directly benefits MDL – Oracle provides dedicated proactive and reactive resources to Life Science partners

Planned Oracle features to be adopted in the future  Support of Oracle 10G Database – MDL is a 10G beta tester  Currently exploring – Oracle Lite for a lightweight database engine in various projects – InterMedia for image storage in Assay Explorer – Ongoing communication regarding other potential collaboration opportunities

Summary  MDL is an established provider of Life Sciences Discovery solutions – Offering an integrated set of software, content and services  MDL integrated with Oracle to meet customer needs since 1989  For more information, visit the MDL table at the Demo Grounds