Principle Metabolic Pathways During Postabsorptive State Process Diagrams Step-by-Step Copyright © 2007 by John Wiley & Sons, Inc.

1 Liver glycogen Glucose LIVER Blood HEARTADIPOSE TISSUE SKELETAL MUSCLE TISSUE OTHER TISSUES

1 Liver glycogen Glucose LIVER Glycerol Blood HEART Fatty acids Glycerol Triglycerides ADIPOSE TISSUE SKELETAL MUSCLE TISSUE OTHER TISSUES 2 Fatty acids

1 Liver glycogen Glucose LIVER Lactic acid Glycerol Blood HEART Fatty acids Glycerol Triglycerides ADIPOSE TISSUE SKELETAL MUSCLE TISSUE OTHER TISSUES 3 2 Fatty acids

1 Liver glycogen Keto acids Glucose Amino acids LIVER Lactic acid Glycerol Blood HEART Muscle proteins Fatty acids Glycerol Triglycerides ADIPOSE TISSUE Fasting or starvation SKELETAL MUSCLE TISSUE OTHER TISSUES Proteins Amino acids Fatty acids

1 Liver glycogen Keto acids Glucose Amino acids LIVER Lactic acid Glycerol Blood HEART Fatty acids Muscle proteins Fatty acids Glycerol Triglycerides ADIPOSE TISSUE Fasting or starvation SKELETAL MUSCLE TISSUE OTHER TISSUES Fatty acids Proteins Amino acids Fatty acids ATP Fatty acids

1 Liver glycogen Keto acids Glucose Amino acids LIVER Lactic acid Glycerol Blood HEART Fatty acids Muscle proteins Fatty acids Glycerol Triglycerides ADIPOSE TISSUE Fasting or starvation SKELETAL MUSCLE TISSUE OTHER TISSUES Fatty acids Proteins Amino acids Fatty acids Lactic acid ATP Fatty acids

1 Liver glycogen Keto acids Glucose Amino acids LIVER Lactic acid Glycerol Blood HEART Fatty acids Muscle proteins Fatty acids Glycerol Triglycerides ADIPOSE TISSUE Fasting or starvation SKELETAL MUSCLE TISSUE OTHER TISSUES Fatty acids Proteins Amino acids Fatty acids Lactic acid ATP Fatty acids

1 Liver glycogen Keto acids Glucose Amino acids LIVER Fatty acids Lactic acid Ketone bodies Glycerol Blood NERVOUS TISSUE Ketone bodies Glucose Starvation HEART Fatty acids Muscle proteins Fatty acids Glycerol Triglycerides ADIPOSE TISSUE Fasting or starvation SKELETAL MUSCLE TISSUE Ketone bodies OTHER TISSUES Fatty acids Proteins Amino acids Fatty acids Ketone bodies Lactic acid ATP

1 Liver glycogen Keto acids Glucose Amino acids LIVER Fatty acids Lactic acid Ketone bodies Glycerol Blood NERVOUS TISSUE Ketone bodies Glucose Starvation HEART Fatty acids Muscle proteins Fatty acids Glycerol Triglycerides ADIPOSE TISSUE Fasting or starvation SKELETAL MUSCLE TISSUE Ketone bodies OTHER TISSUES Fatty acids Proteins Amino acids Glucose 6-phosphate Pyruvic acid Lactic acid Muscle glycogen (aerobic)(anaerobic) Amino acids Fatty acids Ketone bodies Lactic acid ATP O2O2 +O2O2 –