Katarina Haley, Ph.D., CCC-SLP Associate Professor Division of Speech and Hearing Sciences Department of Allied Health Sciences UNC-CH School of Medicine

1. Differential diagnosis of many speech disorders is complex and multi- multidimensional Typically, diagnosis is established subjectively and with unknown reliability and validity Behavioral factors that determine diagnosis can be measured effectively, but procedures are not practical in clinical settings. Acoustic measures Auditory-perceptual ratings Clinicians have limited access to expert resources and second opinion

2. Estimation of severity is neglected Usually determined in a cursory and subjective manner with poor sensitivity and reliability Mild-Moderate-Severe Can be quantified effectively, but procedures are not practical in clinical settings. Acoustic measures Auditory-perceptual ratings

 Quantifies factors that are known to be significant for differential diagnosis and severity estimation  Empirical evidence  Expert opinion  Accounts for coexisting language and/or cognitive difficulties  Multiple presentation modalities  Intuitive interface  Requires minimal time for the patient and the clinician to complete and score  Automated prompting, saving, scoring, data processing  Allows measurements remote in time and place

 Prosody  Rate of speech  Word duration  Pitch variabiltiy  Articulation  Intelligibility  Articulatory precision  Fluency  Restarts/revisions  Initiation delay

 Adults with neurologic speech disorders  Aphasia  Apraxia of Speech  Dysarthria  Right Hemisphere Disorder  Speakers of languages other than English  Auditory perceptual abilities  Children with speech disorders  Cleft lip and palate  Dysarthria (Down’s syndrome)  Fragile X Syndrome  Phonological Disorder  Hearing Loss

 February 2004 – January 2008 (Principal Investigator: K. L. Haley). Computer mediated speech assessment in aphasia and AOS. R03 DC006163, National Institutes of Health (NIDCD)  Subcontract with programmer for pilot software  Report of invention  November 16, 2006 (PCT/US2006/044504). Methods, systems, and computer program products for speech assessment.  US Provisional Patent  US Patent  September 2007 – August 2009) Principal Investigator: David Zajac; Coinvestigators: K. L. Haley and L. Cervidanes ). Speech Intelligibility Testing in Children with Repaired Cleft Palate. R56 DE National Institutes of Health (NIDCR)  April 2009 – April 2011 (Principal Investigator: Dorothy Strickland; Main Consultant: K. L. Haley). Web-Delivered Assessment for Stroke Survivors through Multimedia Technology. R43 DC National Institutes of Health (NIDCD).  Phase 1: Subcontract agreement for main consultant Haley with Virtual Reality Aids  Phase 2: Subcontract and license agreement with Virtual Reality Aids  September 2009 – September 2011 (Principal Investigator: David Zajac, Co-Investigator: K. L. Haley). Speech of Young Males with Fragile X Syndrome. R01HD S109 National Institutes of Health (NICHHD)