ICTR Biostatistics Research Resource Mary Lindstrom Professor, Dept. of Biostatistics and Medical Informatics Director, ICTR Biostatistics Research Resource.

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Presentation transcript:

ICTR Biostatistics Research Resource Mary Lindstrom Professor, Dept. of Biostatistics and Medical Informatics Director, ICTR Biostatistics Research Resource Resource Faculty and Staff 20 UW Faculty Biostatisticians 8 UW Staff Biostatisticians 4 Marshfield Clinic Biostatisticians

ICTR Biostatistics Resource Faculty and Staff Clinical Research UW Faculty: AC Andrei, T Becker, K Buhr, R Chappell, T Cook, M Detry, NM Dowling, M Fisher, P Hutson, R Gangnon, M Lindstrom, M Palta, M Rosenberg, S Wang UW Staff: J Barnet, M Evans, S Hetzel, Z Li, V Rajamanickam, S Seo Marshfield Clinic: R Berg, P Chyou, H Liang Statistical Genetics UW Faculty: K Broman, S Keles, C Kendziorski, R Mau, M Newton, S Wang, B Yandell UW Staff: A Andrei, A Broman Marshfield Clinic: Z Ye

Areas of Expertise Traditional Areas Clinical Trials Prospective Cohort Studies Case Control Studies Retrospective Studies Pre-clinical Studies Special Areas (growing, unique) Statistical Genetics Qualitative Outcomes Cost and Policy Issues Pharmacokinetics & Pharmacodynamics

Biostatistics Resource Activities Consulting Collaborative Research Methodology Research Training Protocol & Pilot Project Review

UW - Madison Resource Funding Model 13.8 FTEs devoted to ICTR Biostatistics

Leveraging UW ICTR Resources Funding Source Activity ICTR (3.7 FTE) Departments & Centers (2.9 FTE) Collab. Grants (5.4 FTE) Method. Grants (1.9 FTE) ConsultingXX CollaborationXXXX MethodologyXX ReviewX

Marshfield Clinic Funding Model Funding SourceFTEs Collaborative Projects2.10 Institutional Support0.10 ICTR FTEs devoted to ICTR Biostatistics

Prioritizing Requests UW - Madison When we have a waiting list: New investigators over established Projects leading to proposals for funding One active project per investigator Deadlines given priority First come, first serve Long term management: Departments, centers, and investigators with substantial use are asked to provide direct funding. All requests must: come from ICTR Members be related to clinical and/or translational research Marshfield Clinic External, large grant proposals Internal proposals Deadlines given priority

Units Using Resource Madison Pediatrics Population Health Sciences Psychiatry Radiology Surgery Other Schools Agricultural and Life Sciences Education Engineering Human Ecology Library and Information Studies Letters and Science Nursing Pharmacy Veterinary Medicine Other Waisman Center Center for Health Enhancement Systems Studies Office of Continuing Professional Development in Medicine and Public Health Department of Veterans Affairs Marshfield Medical School Anatomy Anesthesiology Dermatology Family Medicine Medical Physics Medicine Neurological Surgery Neurology Obstetrics and Gynecology Ophthalmology & Visual Sciences Orthopedics and Rehabilitation Pathology and Laboratory Medicine Pharmacology Cardiology Dermatology Division of Education Internal Medicine Neurology Oncology Pediatrics Rheumatology Sleep Lab Surgery Red indicates funding for individual statisticians

ICTR Biostatistics 2009 Activity UW - MadisonMarshfield Clinic 407 Projects Investigators Collaborative Publications Collaborative Grants Protocols Reviewed Pilot Projects Reviewed

The Future Upgrade the Activity Tracking System to follow: –the life cycle of grants, protocols, manuscripts, –the effect of training and collaboration on investigator success. Increase capacity for qualitative endpoints collaboration. Encourage junior Biostatistics faculty to compete for ICTR pilot grants. Improve interaction between UW and Marshfield Clinic Biostatistics Research Resources.

Examples of Collaboration Clinical Trials Wisconsin Network for Health Research (WiNHR) presented by Mary Lindstrom Stat-Gen Statistical Genetics and Genomics Program presented by Christina Kendziorski

Wisconsin Network for Health Research (WiNHR) A statewide network of clinical sites to collaborate on trials of Diagnostic, preventative and therapeutic interventions Comparative effectiveness Expands capabilities of Wisconsin researchers More studies done faster Population of > 3 million Centralizes some aspects of the research Data management IRB approval process Statistical analysis Each site has a PI and local research staff

WiNHR Sites Marshfield Clinic Gundersen Lutheran UW-Madison Aurora Health Care

WiNHR Studies Protocols come from all participating sites are funded independently Studies 9 ongoing, 1 completed 712 patients accrued 8 different lead investigators 9/10 studies use 3 or 4 sites.