Complete list of LC-MS myc interating protiens in the MCF7 cells, proteins highlighted in red are those differentially expressed from the LCC1 and LCC1.

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Complete list of LC-MS myc interating protiens in the MCF7 cells, proteins highlighted in red are those differentially expressed from the LCC1 and LCC1 EGF treated cells. Supplemental Table S1 MCF7IdentifierUniprot Acc codeMrNo. of pepides Log (e) Band No. 4F2 cell-surface antigen heavy chain (4F2hc) ENSP P kDa glucose-regulated protein precursor (GRP 78) ENSP P Actin-like protein (Fragment) ENSP Q562S actin-like protein Source: RefSeq_peptide NP_ ENSP n/a Alpha enulase ENSP P Alpha-actinin 4 (F-actin cross linking protein) ENSP O Annexin A2 (Annexin II) ENSP n/a Antileukoproteinase 1 precursor (ALP) ENSP P Apolipoprotein E precursor (Apo-E). ENSP P BA13B9.3 (NOVEL PROTEIN SIMILAR TO KRT8) ENSP n/a Beta-catenin (PRO2286) ENSP P Clathrin heavy chain 1 ENSP Q Cytokeratin type II. ENSP O Desmoplakin ENSP P Fatty acid synthase ENSP P Filamin B (FLN-B) (Beta-filamin) ENSP O Filamin-A (Alpha-filamin) (Filamin-1) ENSP P Fructose-bisphospate aldolasea ENSP P Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) ENSP P Heat shock 70 kDa ENSP P Heat shock 70 kDa protein 1 ENSP P Heat shock cognate 71 kDa protein ENSP P Heat shock protein HSP 90beta ENSP P Histone H2B.f (H2B/f) (H2B.1). ENSP P Histone H4 ENSP P Ig alpha-1 chain C region ENSP P Junction plakoglobin (Desmoplakin III). ENSP P K0256 Isoform 2ENSP Q Keratinocyte proline-rich protein (hKPRP) ENSP Q5T Lipin-3 (Lipin 3-like)ENSP Q9BQK L-lactate dehydrogenase B chain ENSP P Lysozyme C precursor ENSP P Malate dehydrogenase, mitochondrial precursor ENSP P Nuclear receptor corepressor 2 (N-CoR2) (SMRT) (SMRTe) ENSP Q9Y Predicted: similar to 60S ribosomal protein ENSP n/a Protein disulfide-isomerase A3 precursor ENSP P Puromycin-sensitive aminopeptidase(PSA) ENSP P Pyruvate kinase, isozymes M1/M2 ENSP P Receptor tyrosine-protein kinase erbB-4 precursor ENSP Q Stress-70protein, mitochondrial precursor ENSP P Transkeltolase ENSP B4E type I hair keratin KA35 ENSP Q6A Ubiquitin-activating enzyme E1 ENSP P

Supplemental Table S2 Complete list of LC-MS myc interating protiens in the LCC1 cells, proteins highlighted in red are those differentially expressed from the LCC1 EGF and MCF7 cells

Supplemental Table S3 Complete list of LC-MS myc interating protiens in the LCC1 EGF treated cells, proteins highlighted in red are those differentially expressed from the LCC1 and MCF7 cells

Supplemental Table S4 Clinical trials examining the potential benefit of trastuzumab in Her2 low/Her2 negative breast cancer patients