Global Forum for Health Research Mumbai, September 12 to 16 2005 1 Rob Ridley Director, TDR Sustaining Priority Research for Neglected Tropical Diseases.

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Presentation transcript:

Global Forum for Health Research Mumbai, September 12 to Rob Ridley Director, TDR Sustaining Priority Research for Neglected Tropical Diseases

Global Forum for Health Research Mumbai, September 12 to To undertake research, development and evaluation of new and improved tools and interventions to fight major tropical diseases To strengthen research capabilities in countries where these diseases are endemic –enhanced stakeholdership / ownership of research TDR 'twin' Mission

Global Forum for Health Research Mumbai, September 12 to A vicious cycle

Global Forum for Health Research Mumbai, September 12 to Many 'Neglected Diseases' Infectious and Parasitic diseases (000) HIV/AIDS ¨ Diarrhoeal diseases ¨ Tuberculosis ¨ Malaria ¨ Childhood diseases ¨ STI (excluding HIV) 180 ¨ Meningitis 173 ¨ (Other) Tropical Diseases 129 ¨ Hepatitis B 103 ¨ Hepatitis C 54 ¨ Dengue 19 ¨ Japanese encephalitis 14 ¨ Intestinal nematode 12 ¨ Leprosy 6 ¨ Mortality Estimates for 2002 (World Health Report 2004)

Global Forum for Health Research Mumbai, September 12 to 'Neglected' Diseases affect 'Neglected' Populations

Global Forum for Health Research Mumbai, September 12 to Priority Setting

Global Forum for Health Research Mumbai, September 12 to Strategy ?? Tropical Disease Burden Poverty Control/ Elimination Of Tropical Diseases Poverty reduction

Global Forum for Health Research Mumbai, September 12 to NIH, Trust, Research councils etc. Grand Challenges Innovation to Impact

Global Forum for Health Research Mumbai, September 12 to Need to sustain and increase basic science funding

Global Forum for Health Research Mumbai, September 12 to Product Development

Global Forum for Health Research Mumbai, September 12 to Examples of public private partnerships that have delivered new tools

Global Forum for Health Research Mumbai, September 12 to Microbicides MMV IAVI FIND GATB MVI EDCTP DNDi Innovation to Impact – product development

Global Forum for Health Research Mumbai, September 12 to new drugs anticipated by 2010 Proposed fund of $200M per year to complement PPP's Product Development Activities Need Sustaining

Global Forum for Health Research Mumbai, September 12 to Much variation by disease (e.g. Gates)

Global Forum for Health Research Mumbai, September 12 to Evaluation and Implementation Research

Global Forum for Health Research Mumbai, September 12 to Onchocerciasis –Ivermectin and Community Directed Treatment Malaria –Home management of malaria strategies Visceral Leishmaniasis –Tools in place for 'elimination' programmes Examples of TDR – mediated evaluation and implementation research A critical area for future funding given increase of tools in pipeline

Global Forum for Health Research Mumbai, September 12 to New tools stimulate India / Nepal / Bangladesh to sign MoU for elimination of VL by 2015 Local ownership of research critical Recognition of significance of social, economic and behavioural research Research must be embedded in and owned by countries and integrated into health systems Inter-country coordination facilitated by WHO / SEARO / TDR Requires a co-ordinated approach by partners for maximal impact Example in progress Visceral Leishmaniasis

Global Forum for Health Research Mumbai, September 12 to Innovation to Impact

Global Forum for Health Research Mumbai, September 12 to Innovation to Impact

Global Forum for Health Research Mumbai, September 12 to Look beyond single issues Managing Interfaces

Global Forum for Health Research Mumbai, September 12 to Maintained funding for basic science, continued innovation and PPP product development –Better balance for more neglected diseases –Better management of translation research Enhanced Evaluation and Implementation Research for all diseases Enhanced coordination and interaction between initiatives, funding agencies, governments and regional bodies –Role for international agencies Challenges No. 1

Global Forum for Health Research Mumbai, September 12 to Look beyond single issues Cross-cutting issues

Global Forum for Health Research Mumbai, September 12 to Need capacity building coupled to capacity utilisation Need to enhance country participation, 'stakeholdership' and ownership of research Need to 'embed' the output of research activities within the institutions of developing countries Need to enhance capabilities of developing countries to engage in 'innovation' as well as implementation Challenges No. 2

Global Forum for Health Research Mumbai, September 12 to Use-inspired Research