Prolozone Therapy Workshop Dr. James Lemire FAAFP,CFMP October 22, 2015

Credentials: Education BA 1968-1972 University Massachusetts Board Certifications Family Practice Initial certification: 1979 (Recertified: 1985, 1991, 1997, 2004 and 2014 )   American College Sports Medicine–certified team physician-1986   American College for Advancement of Medicine-Basic Chelation 2001 International Oxidative Medicine Assoc. Board certification-2002   American College for Advancement of Medicine- CCT – 2011   Institute of Functional Medicine Certified Practitioner – 2013 Education BA 1968-1972 University Massachusetts Amherst, Mass Phi Beta Kappa MD 1972-1976 Tulane University Medical School New Orleans, La

Professional Experience 1979-1997 Lakewood Family Medicine Holland, Mi Family Physician Founded a practice There were 9 Family Physicians and 3 PA’s 1998-1999 Family Care Specialists, Ocala, Fl 2000-present James E Lemire MD PA Ocala, Fl Lemire Clinic Founded Functional medicine family practice Including chelation therapy and IV nutrition 2011-present Medical Director / Founder Connections Community Clinic for the Homeless and Indigents 2012-present Xymogen Nutraceuticals Medical Board of Advisors 2014-present Lemire Family Practice PLLC. Personalized Health Care Practice

Memberships American College for Advancement of Medicine Professional American Academy of Family Practice Memberships American College for Advancement of Medicine Christian Medical and Dental Association Institute of Functional Medicine Academy Comprehensive Integrative Medicine (ACIM) Publications Ray and Lemire 1995 “Liver laceration in an Intercollegiate Football player.” Journal of Athletic Training. Krupp, Lee, Diem and Lemire 1975 “Prognostic Parameters in Clinical Staging Criteria in Epidermoid Carcinoma of the Vulva.” Obstetrics and Gynecology (research mentioned in Dr Barry Sears book “The Zone and Omega 3 Therapy”) Natural Awakenings Magazine 2011-present Ultimate Guide for Natural Health in the 21st Century 2012 E-book Top 20 Alternative Doctors in America 2013 - Contributor

Outline What is prolozone? History of prolotherapy & prolozone Who invented prolozone & when? Why prolozone & who benefits? How is prolozone done? Where is it done? Dr. Rowen pearls Summary-review

Definitions Ozone therapy is the use of medical grade ozone (highly reactive pure 03) to create healing and regeneration within the body. Prolozone is a new phrase combining the word ozone and the Latin word prioli which means to regenerate or rebuild.

OZONE REGULATES OXIDATIVE STRESS IMPROVES METABOLISM OF OXYGEN METABOLIC REGULATOR BROAD SPECTRUM GERMICIDE IMPROVES METABOLISM OF OXYGEN

History Ozone was first discovered in 1840 by Christian Friedrich Schonbein. In 1932, Swiss dentists first used ozonated water as a disinfectant. In 1950, two German doctors developed the first ozone generator for medical use. European clinics have practiced ozone therapy for 50 years or more. Ozone therapy was first introduced in the US in the early 1980s, and has been increasingly used ever since. Prolozone therapy, developed by Frank Shallenberger MD, is a combination of ozone therapy , neural therapy and prolotherapy

Uses of Ozone Therapy Ozone has been shown to be highly successful in a wide variety of clinical conditions: Diabetic foot ulcers Dental root canal infections & chronic gingivitis Elephantiasis Bedsores, psoriasis, eczema Tinnitus, vertigo, migraines Dyspnea of any origin

Prolozone is a mixture of Ozone and other active ingredients: Procaine B 12 B6 Dextrose Homeopathics others

0zone (O3) Unstable & needs extra electrons Creates peroxides that penetrate membranes Oxidizes NADH to NAD & generates O2 This process of hyper-oxygenation and NADH oxidation drives the cell into an elevated ATP production mode. Given the right nutrients and anti-inflammatories, the cell heals itself and the surrounding tissue.

Procaine Blocks pain Stabilizes and restores damaged neurological membrane potentials (NEURO reset)

Vitamin B 12 B12 is water-soluble & safest form is hydroxocobalamin Critical to healthy nerves and red blood cells Utilized in protein metabolism Promotes healthy collagen formation Utilized in inflammation reduction within cells Is bright red in its natural form

Vitamin B6 Vitamin B6 is water-soluble Vital for conversion of food to energy Utilization of proteins Important for collagen formation

Dextrose Blocks the capsaicin receptor Inhibits substance P Blocks cyclic inflammation Tightens bonds between collagen-rich tissue i.e. tendons , ligaments, cartilage & joint capsules

Homeopathics Homeopathic anti-inflammatories Regenerative Traumeel: pain-reducing homeopathic Zeel: cartilage-rebuilding homeopathic

Why Prolozone? Pain reduction Tissue regeneration Avoid surgery Cost responsibility Rapid recovery Patient demand- there is a transition happening Less is more

Complications of Surgery Surgical error Complications- bleeding, infection, others Pain Scar tissue Decreased function and range of motion Delay return to normal activity (recovery) Nerve damage Other

Unnecessary Surgery

In this controlled trial involving patients with osteoarthritis of the knee, the outcomes after arthroscopic lavage or arthroscopic débridement were no better than those after a placebo procedure.

Who Benefits from Prolozone? Everyone, Everywhere!

Common Sports Injuries

Sprains/strain/pulls/tears/fracture All tissue it designed with give & have elasticity. Sprains, strains holes, tears and even fractures are result of the forces of injury overcoming the elasticity of the tissue involved.

Cumulative Injury Cycle

BASIC….. IT CAN BECOME VERY EXOTIC. How To Make Ozone machine: for most injections set 20 to 50 gamma Some research suggests higher settings, some lower **Vital to use pure oxygen and not a concentrator Use within 10 minutes of drawing The mix: 0.5 to 1 mL of dextrose 5% 1-2 mL of B12 (5 mg/mL) 0.5-1 mL of B6 open ( 5 mg/mL) ½ - 1 vial of Traumeel and or Zeel 6-8 mL of procaine 2% BASIC….. IT CAN BECOME VERY EXOTIC.

Where To Give Areas to avoid: the spinal column Everywhere it hurts. C1-C4 no man’s zone….or woman’s Avoid the vertebral arteries avoid large vessels Avoid direct injection into large nerves * Can treat around them all day long.

Conditions Responsive to Prolozone Sinus infections Sciatica Plantar fasciitis Carpal tunnel syndrome Rotator cuff tears Tennis elbow and virtually any other sports injury. Pelvic disorders TMJ Neck pain Hip Pain Back pain Knee pain Degenerated discs Herniated discs Post-surgical pain Dental infections Non-union fractures

Prolozone Summary Bypasses the wall of inflammation and edema Nutrients and oxygen are placed at the point of need for rebuilding tissue Used for decades- with extensive research & success Safe Effective 75 to 95% recovery combined with proper diet and supplementation success rate is even higher

References

Pearls by Dr. Robert Rowen Why do we often get immediate results that are lasting when the effects of local anesthetic are gone in minutes? Answer: Procaine works instantly so you know that you got your treatment in the right spot when you relieve the patient of pain from the injection. But when the pain doesn’t return after 30 to 60 minutes something else is happening. Ozone has gone to work immediately to lower/modulate inflammatory mediators. It is the inflammation that causes pain. Knock out the inflammation & you knock out the pain. The oxygen residue is directly “what the doctor ordered” for oxygen starved tissues. Hypoxic cells cannot regenerate or repair. They have just been given a free bolus of desperately needed oxygen into tissues where diffusion may be impaired.

Robert Rowen M.D.

What about delayed side effects? Usually there is some change with the injection, helping you feel comfortable that you’ve chosen the correct site. But the real effect steps in about 2 to 5 days later. Why the delay? I believe it’s a situation were the mere presence of ozone to modulate the inflammation is not enough for an instant effect. It requires several more days for the ATP induced by the new presence of oxygen to show up in the form of actual tissue healing and pain reduction.

Dr. Rowen’s success rates Knees, neck, backs-approximate 80 - 85% overall improvement. Hips with a lateral approach about 50% improvement or with anterior approach which some teach approximate 66% overall improvement. plantar fasciitis close to 100% Shoulders 50% clearing of frozen shoulder quickly may need 3 to 4 more treatments. ankle sprains - 80%

Prolozone VS Prolotherapy Ozone being a gas, spreads quickly far and wide. So unlike prolotherapy you don’t have to be spot on. The gas travels and seemingly everywhere it flows/touches, healing is enabled. Prolotherapy use requires 20/30 more needle sticks than prolozone. Prolotherapy can make the patient worse for the first 48 hours before benefits begin kicking in. Patients come in sometimes reluctant for prolotherapy because they know they might feel worse tomorrow. Precision injections required which taxes the individual physician

Dr. Rowen’s failures/pitfalls No one ever gets 100% Some patients are slow to come around. It may take 4 to 6 sessions to finally show improvement. Keep it up, they usually have improvement within the six sessions. Usually with continued improvement. If no improvement within six sessions, I will discontinue. The Cubans will go to 10. No need to hit the right area although, since the gas is very forgiving.

Final Thoughts Prolozone is easy to tolerate If it hurts, it only does so for about 60 seconds Faster results Better results Patients are eager to come back for more treatments if needed Help patients to avoid surgery where they are told: “There is bone on bone which requires joint replacement”

Additional References: Thank you