03_37 Mitosis and cytokinesis Slide number: 1 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Early interphase Restriction checkpoint Cleavage furrow Nuclear envelope Chromatin fibers Centrioles Mitosis Cytokinesis G 1 phase S phase G 2 phase Interphase A B Aster Microtubules Centromere Spindle fiber Sister chromatids Late prophase Prophase Late interphase MetaphaseAnaphase CD Chromosomes Nuclear envelopes E Telophase and cytokinesis

03_37 Mitosis and cytokinesis Slide number: 2 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Early interphase of daughter cells— a time of normal cell growth and function. Restriction checkpoint Mitosis Cytokinesis G 1 phase S phase G 2 phase Interphase A

03_37 Mitosis and cytokinesis Slide number: 3 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Nuclear envelope Chromatin fibers Centrioles Mitosis Cytokinesis G 1 phase S phase G 2 phase Interphase Late Interphase Cell has passed the restriction checkpoint and completed DNA replication, as well as replication of centrioles and mitochondria, and synthesis of extra membrane. Restriction checkpoint

03_37 Mitosis and cytokinesis Slide number: 4 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Mitosis Cytokinesis G 1 phase S phase G 2 phase Interphase B Aster Microtubules Prophase Chromosomes condense and become visible. Nuclear envelope and nucleolus disperse. Spindle apparatus forms.

03_37 Mitosis and cytokinesis Slide number: 5 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Mitosis Cytokinesis G 1 phase S phase G 2 phase Interphase B Centromere Spindle fiber Sister chromatids Late prophase

03_37 Mitosis and cytokinesis Slide number: 6 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Mitosis Cytokinesis G 1 phase S phase G 2 phase Interphase C Metaphase Chromosomes align along equator, or metaphase plate of cell.

03_37 Mitosis and cytokinesis Slide number: 7 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Mitosis Cytokinesis G 1 phase S phase G 2 phase Interphase D Anaphase Sister chromatids separate to opposite poles of cell.

03_37 Mitosis and cytokinesis Slide number: 8 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Cleavage furrow Mitosis Cytokinesis G 1 phase S phase G 2 phase Interphase Chromosomes Nuclear envelopes E Telophase and cytokinesis Nuclear envelopes begin to reassemble around two daughter nuclei. Chromosomes decondense. Spindle disappears. Division of the cytoplasm into two cells.

03_37 Mitosis and cytokinesis Slide number: 9 Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Early interphase of daughter cells— a time of normal cell growth and function. Restriction checkpoint Mitosis Cytokinesis G 1 phase S phase G 2 phase Interphase A