Copyright © 2006 Pearson Education, Inc. publishing as Benjamin Cummings PowerPoint® Lectures for Biology: Concepts and Connections, Fifth Edition – Campbell, Reece, Taylor, and Simon Essential Biology, Second Edition – Campbell, Reece, and Simon Essential Biology with Physiology – Campbell, Reece, and Simon Lectures by April Lynch Tumor-Busting Viruses Current Issues in Biology, Volume 2 Scientific American

Copyright © 2006 Pearson Education, Inc. publishing as Benjamin Cummings Concept Review Tumor-Busting Viruses How can doctors kill cancer cells without harming healthy ones? Such targeted treatment is one of the biggest challenges in cancer care. This image shows how cancerous cells intermingle with healthy ones. Melanoma, or skin cancer cells, are shown in green amid healthy cells, shown in red.

Copyright © 2006 Pearson Education, Inc. publishing as Benjamin Cummings Concept Review Tumor-Busting Viruses A new answer may lie in virotherapy. This type of treatment uses scientifically-engineered viruses to target cancer cells.

Copyright © 2006 Pearson Education, Inc. publishing as Benjamin Cummings Concept Review Tumor-Busting Viruses Some viruses, such as engineered adenoviruses, show promise at selecting and destroying cancer cells. They kill tumor cells by invading through unique receptors on the surface of cancer cells, and then burst the cells open or make them more vulnerable to traditional chemotherapy.

Copyright © 2006 Pearson Education, Inc. publishing as Benjamin Cummings Concept Review Tumor-Busting Viruses Here are examples of cancer experiments involving virotherapy.

Copyright © 2006 Pearson Education, Inc. publishing as Benjamin Cummings Testing Your Comprehension Tumor-Busting Viruses What is virotherapy? a) stimulating cancer tissue with sonic pulses b) exposing patients to cold viruses to boost their immunity c) applying engineered viruses to infect and kill cancer cells d) putting patients in a pressure chamber during treatment

Copyright © 2006 Pearson Education, Inc. publishing as Benjamin Cummings Biology and Society Tumor-Busting Viruses If I were diagnosed with a deadly form of cancer, and were offered the chance to join a virotherapy research trial, I’d be willing to try this experimental therapy. Strongly Agree Strongly Disagree A. E. C. B. D.

Copyright © 2006 Pearson Education, Inc. publishing as Benjamin Cummings Thinking about Science Tumor-Busting Viruses What would be important medical safety steps to include in a research trial studying whether a certain brain cancer could be fought with engineered adenovirus?

Copyright © 2006 Pearson Education, Inc. publishing as Benjamin Cummings Interpreting Data and Graphs Tumor-Busting Viruses Using this illustration as a guide, describe how an engineered virus can infect and kill a cancer cell, while leaving a healthy cell alone.