1. Copyright © 2006 Pearson Education, Inc. publishing as Benjamin Cummings PowerPoint® Lectures Lectures by Chris Romero, Front Range Community College Whose Blood Is It, Anyway? Current Issues in Biology, Volume 1 Scientific American

2. Copyright © 2006 Pearson Education, Inc. publishing as Benjamin Cummings Whose Blood Is It, Anyway? Concept Review Since 1998, hundreds of lives have been saved by blood contained in the placenta and umbilical cord. This blood contains hematopoietic stem cells which can develop into many kinds of blood cells and be used to treat many diseases. The cells have been used to treat leukemia, sickle cell disease and severe combined immunodeficiency syndrome.

3. Copyright © 2006 Pearson Education, Inc. publishing as Benjamin Cummings Whose Blood Is It, Anyway? Concept Review The first cord blood transfusion occurred in 1972, but its potential was not fully realized until 1989. Cord blood is better for transplantation than child or adult bone marrow because it is less likely to cause graft-versus- host disease.

4. Copyright © 2006 Pearson Education, Inc. publishing as Benjamin Cummings Whose Blood Is It, Anyway? Umbilical cord blood transplantation has many advantages over bone marrow transplant. - The size of the donor pool is much larger. - Cord blood is readily available from a blood bank’s freezer. Concept Review

5. Copyright © 2006 Pearson Education, Inc. publishing as Benjamin Cummings Whose Blood Is It, Anyway? Concept Review Cord blood transplantation is not without risks. - The stem cells might contain genetic mistakes that could cause a disease in a recipient. - It contains relatively small numbers of stem cells in a single sample.

6. Copyright © 2006 Pearson Education, Inc. publishing as Benjamin Cummings Whose Blood Is It, Anyway? Immediately after birth, blood can be collected from the umbilical cord and ________, also called the after birth. a) uterus b) placenta c) uvula d) stem cells Testing Your Comprehension

7. Copyright © 2006 Pearson Education, Inc. publishing as Benjamin Cummings Whose Blood Is It, Anyway? Testing Your Comprehension Immediately after birth, blood can be collected from the umbilical cord and ________, also called the after birth. b) placenta

8. Copyright © 2006 Pearson Education, Inc. publishing as Benjamin Cummings Whose Blood Is It, Anyway? Which of these conditions is least likely to be successfully treated using cord blood stem cells? a) leukemia b) sickle cell disease c) breast cancer d) immune disorders, such as sever combined immunodeficiency (SCID) Testing Your Comprehension

9. Copyright © 2006 Pearson Education, Inc. publishing as Benjamin Cummings Whose Blood Is It, Anyway? Testing Your Comprehension Which of these conditions is least likely to be successfully treated using cord blood stem cells? c) breast cancer

10. Copyright © 2006 Pearson Education, Inc. publishing as Benjamin Cummings Whose Blood Is It, Anyway? Why are immune cells extracted from umbilical cord blood better for transplantation than those in child or adult bone marrow? a) They are less likely to cause cancer. b) They are less likely to cause graft-versus-host disease. c) They are denser and thus easier to transplant. d) They can develop into more types of cells. Testing Your Comprehension

11. Copyright © 2006 Pearson Education, Inc. publishing as Benjamin Cummings Whose Blood Is It, Anyway? Testing Your Comprehension Why are immune cells extracted from umbilical cord blood better for transplantation than those in child or adult bone marrow? b) They are less likely to cause graft-versus-host disease.

12. Copyright © 2006 Pearson Education, Inc. publishing as Benjamin Cummings Whose Blood Is It, Anyway? For-profit companies will charge large fees to preserve a newborn’s cord blood for possible use by the family later? Is that right when the chance a child will ever need his or her cord blood ranges from 1 in 10,000 to 1 in 200,000? Strongly Agree Strongly Disagree A. E. C. B. D. Biology In Society

13. Copyright © 2006 Pearson Education, Inc. publishing as Benjamin Cummings Whose Blood Is It, Anyway? Biology In Society React to the following statement: I would consider umbilical cord blood banking for my baby. Strongly Agree Strongly Disagree A. E. C. B. D.

14. Copyright © 2006 Pearson Education, Inc. publishing as Benjamin Cummings Whose Blood Is It, Anyway? Assume that a mother and father are both heterozygous with different alleles for a particular HLA gene (and thus have four different alleles for that gene). What are the odds that their two children will have HLA alleles for this gene that match each other? a)100% b)50% c)25% d)0% Thinking About Science

15. Copyright © 2006 Pearson Education, Inc. publishing as Benjamin Cummings Whose Blood Is It, Anyway? Thinking About Science Assume that a mother and father are both heterozygous with different alleles for a particular HLA gene (and thus have four different alleles for that gene). What are the odds that their two children will have HLA alleles for this gene that match each other? c)25%