 During DNA replication, the two strands of the original parent DNA molecule, shown in blue, each serve as a template for making a new strand, shown in.

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Presentation transcript:

 During DNA replication, the two strands of the original parent DNA molecule, shown in blue, each serve as a template for making a new strand, shown in yellow. Replication results in two daughter DNA molecules, each consisting of one original strand and one new strand.

 DNA replication begins at origins of replication and proceeds in both directions, producing "bubbles." Eventually, all the bubbles merge, resulting in two separate daughter DNA molecules.

 Replication Replication Replication

Protein Synthesis  The DNA that makes up the human genome can be subdivided into information bytes called genes.. The DNA that makes up the human genome can be subdivided into information bytes called genes..

Protein Synthesis  Each gene encodes a unique protein that performs a specialized function in the cell.  The human genome contains more than 25,000 genes

Protein Synthesis  Cells use the two-step process of transcription and translation to read each gene and produce the string of amino acids that makes up a protein. Cells use the two-step process of transcription and translation to read each gene and produce the string of amino acids that makes up a protein.

Protein Synthesis  We have already seen the roles that different enzymes play in building the cell's structure and in catalyzing metabolic reactions, but where do proteins come from?

Protein Synthesis  To manufacture proteins, cells follow a very systematic procedure that first transcribes DNA into mRNA and then translates the mRNA into chains of amino acids. The amino acid chain then folds into specific proteins.

Step 1: DNA Transcription  Protein synthesis begins in the cell's nucleus when the gene encoding a protein is copied into RNA.  Genes, in the form of DNA, are embedded in in the cell's chromosomes..

Step 1: DNA Transcription  The process of transferring the gene's DNA into RNA is called transcription.  Transcription helps to magnify the amount of DNA by creating many copies of RNA that can act as the template for protein synthesis.  The RNA copy of the gene is called the mRNA

Step 1: DNA Transcription  DNA and RNA are both constructed by a chain of nucleotides.  However, RNA differs from DNA by the substitution of uracil (U) for thymine (T).  Also, because only one strand of mRNA is needed when synthesizing proteins, mRNA naturally exist in single-stranded forms.

After transcription, the mRNA is transported out of the cell's nucleus through nuclear pores to go to the site of translation, the rough endoplasmic reticulum

Step 2: RNA Translation  After the mRNA has been transported to the rough endoplasmic reticulum, it is fed into the ribosomal translation machineries.

Step 2: RNA Translation  Ribosomes begins to read the mRNA sequence from the 5` end to the 3` end.  To convert the mRNA into protein, tRNA is used to read the mRNA sequence, 3 nucleotides at a time.

Step 2: RNA Translation  Amino acids are represented by codons, which are 3-nucleotide RNA sequences.

Step 2: RNA Translation  The mRNA sequence is matched three nucleotides at a time to a complementary set of three nucleotides in the anticodon region of the corresponding tRNA molecule.

Step 2: RNA Translation  Opposite the anticodon region of each tRNA, an amino acid is attached and as the mRNA is read off, the amino acids on each tRNA are joined together through peptide bonds.