Lecture 15. Maintaining blood Glc levels Glucose is the energy source for many tissues Need to keep blood glucose level constant Not taking in Glc  Blood.

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Presentation transcript:

Lecture 15

Maintaining blood Glc levels Glucose is the energy source for many tissues Need to keep blood glucose level constant Not taking in Glc  Blood glucose falls How to put Glc into blood?

Carbon sources for Gluconeogeneis: Cori cycle

Carbon sources for Gluconeogeneis

Gluconeogenesis Reverse of glycolysis What step/s have to be different?

Cellular compartments Where does Glycolysis occur? Where does TCA occur?

Compartmentalization

1: How to make PEP? Cannot directly convert Pyruvate to PEP So, make Oxaloacetate

1: How to make PEP? Metabolite compartmentalization must be overcome

1: How to make PEP?

2: If you don’t like it!

Remember Fru 2,6-bis-PO 4 ?

3. If you really don’t like it!

Reversing Glycolysis

Avoiding “futile” cycles

Signaling cascade recap LIVER Example 2: Phosphofructokinase 2 Pancreas Low Glc ? ? Fru 2,6 bis-PO 4 Adenylate cyclase ? PKA ? ? PFK1; ? FBPase1 ? GLYCOLYSIS ? GLUCONEOGENESIS

Coordinating metabolism: Recap Decreased Blood sugar Make hormone: ___________________ Effect on liver: ___________________ Effect on muscle: ___________________ Effect on adipose tissue: ___________________ Increase Blood sugar Make hormone: ___________________ Effect on liver: ___________________ Effect on muscle: ___________________ Effect on adipose tissue: ___________________