T H O M S O N S C I E N T I F I C Bonnie Snow Research Director, Clinical Content & Applications Whats New: Sept 2007 – March 2008 SLA Pharmaceutical & Health Technology Division Spring Meeting, April 2008, St. Petersburg, FL

Copyright 2008 Thomson Corporation 2 T H O M S O N S C I E N T I F I C Thomson Pharma ® Content Drugs - more than 28,000 (approx. 150 added each month) Companies - 7,500 (includes other organizations involved in drug development, e.g., academic, government) Meetings – 400 meetings/year, information from key conferences published overnight Patents - information from 41 patent-issuing authorities Journals – information from more than 11,000 peer-reviewed journals Compounds – more than 3 million (approx. 5,000 added each month) Sequences – more than 8 million (approx. 16, ,000 added each month) Targets – 5,200+

Copyright 2008 Thomson Corporation 3 T H O M S O N S C I E N T I F I C Content is delivered in structured, cumulative reports

Copyright 2008 Thomson Corporation 4 T H O M S O N S C I E N T I F I C Content

Copyright 2008 Thomson Corporation 5 T H O M S O N S C I E N T I F I C Specialty Current Awareness Home Pages Biology Chemistry Clinical Pipeline Clinical Trials Licensing & Business Development Competitive Intelligence News & Meetings Intellectual Property Regulatory Affairs Brand Management Generic Competition Create your own……

Copyright 2008 Thomson Corporation 6 T H O M S O N S C I E N T I F I C Each Subject or Specialty homepage provides a selection of current awareness portlets.

Copyright 2008 Thomson Corporation 7 T H O M S O N S C I E N T I F I C Whats New? Detailed information on DEALS in Thomson Pharma –A Deal is a collaborative or licensing agreement between two companies Thomson Pharma Drug & Company Reports already incorporate textual summaries of licensing agreements –Reports now include links to Deal Reports for additional information about each agreement Enhanced coverage introduced in September 2007 –Separate reports on each Deal, with detailed financial data and event history Highly structured, fielded data provides advanced search capabilities –Two new current awareness portlets, filterable by therapy area

Copyright 2008 Thomson Corporation 8 T H O M S O N S C I E N T I F I C Two new current awareness portlets introduced on the Licensing & Business homepage

Copyright 2008 Thomson Corporation 9 T H O M S O N S C I E N T I F I C Users can add these portlets to their personal homepages, along with other preferred selections from a menu of 25 current awareness portlets now available in Thomson Pharma ®

Copyright 2008 Thomson Corporation 10 T H O M S O N S C I E N T I F I C

Copyright 2008 Thomson Corporation 11 T H O M S O N S C I E N T I F I C

Copyright 2008 Thomson Corporation 12 T H O M S O N S C I E N T I F I C

Copyright 2008 Thomson Corporation 13 T H O M S O N S C I E N T I F I C

Copyright 2008 Thomson Corporation 14 T H O M S O N S C I E N T I F I C

Copyright 2008 Thomson Corporation 15 T H O M S O N S C I E N T I F I C

Copyright 2008 Thomson Corporation 16 T H O M S O N S C I E N T I F I C Search Form [continued]: Additional DEAL filtering options

Copyright 2008 Thomson Corporation 17 T H O M S O N S C I E N T I F I C DEAL FINDER capability added to Guided Search options

Copyright 2008 Thomson Corporation 18 T H O M S O N S C I E N T I F I C

Copyright 2008 Thomson Corporation 19 T H O M S O N S C I E N T I F I C Whats New? New Specialty section devoted to Clinical Trials Two new types of reports added to Thomson Pharma –Structured summaries of trial Protocols and Outcomes Determine status & progress of clinical research not just at the drug and company level, but also at the specific study level: e.g., number of studies, size and scope, expected duration Compare outcomes measures used, drugs identified as active controls, randomization and masking, patient eligibility parameters Adapt trial design & development program to address emerging competitive issues & ensure that evidence obtained from studies is not only adequate for product approval, but also for effective product positioning & rapid adoption, once launched Site and clinical investigator selection Identifying trends and benchmarking

Copyright 2008 Thomson Corporation 20 T H O M S O N S C I E N T I F I C Whats New? New Specialty section devoted to Clinical Trials Two new types of reports added to Thomson Pharma –Structured summaries of trial Protocols and Outcomes –Linked to relevant Drug and Company Reports in Thomson Pharma New current awareness portlets to assist in monitoring trial developments Sources: company websites, press releases, conferences, journals, protocol registries, including Clinical Trials.gov, ISRCTN register, WHO ICTRP portal (China, India, Australia/NZ), Japan, IFPMA portal

Copyright 2008 Thomson Corporation 21 T H O M S O N S C I E N T I F I C New Specialty Section & Current Awareness Portlets

Copyright 2008 Thomson Corporation 22 T H O M S O N S C I E N T I F I C Adjust time period & units (weeks/months) depicted in display Change to tabular summary, if desired Hovering over a given data point invokes display of further details

Copyright 2008 Thomson Corporation 23 T H O M S O N S C I E N T I F I C

Copyright 2008 Thomson Corporation 24 T H O M S O N S C I E N T I F I C Protocol Trends portlet – User interaction with graph affects content of histograms Clicking on data elements in histograms leads directly to designated protocols

Copyright 2008 Thomson Corporation 25 T H O M S O N S C I E N T I F I C Thomson Pharma Value-Added Features: Protocols Enhance minimum standards set by FDA & WHO with additional controlled vocabulary/thesaurus terms –Benefits: Easier to search – predictable & browsable, with options for refining results with greater precision than typically offered in public protocol registries Hierarchical indexing: broad Therapeutic Categories & Mechanism of Action classification –Benefits: Facilitates assessments in prospective market areas by bringing together protocols or results otherwise found under a variety of specific indications terms Add alternative drug names/synonyms & CAS RNs –Benefits: Enhanced accessibility beyond name(s) cited in original Protocol or Outcomes reports X-Links to Outcomes (trial results) Reports associated with individual Protocols –Benefits: Cuts research time to gather relevant info

Copyright 2008 Thomson Corporation 26 T H O M S O N S C I E N T I F I C Direct link to associated Outcomes Report, when available

Copyright 2008 Thomson Corporation 27 T H O M S O N S C I E N T I F I C Sponsors & Collaborators: Standardized T-Pharma organization names Added organization classification: Industrial, Academic, Government

Copyright 2008 Thomson Corporation 28 T H O M S O N S C I E N T I F I C Study Phase terms: Not specified Phase 0 Phase 1 Phase 1/Phase 2 Phase 2 Phase 2a Phase 2b Phase 2/Phase 3 Phase 3 Phase 3b Phase 4 Enhance minimum standards set by FDA & WHO with additional controlled vocabulary/thesaurus terms

Copyright 2008 Thomson Corporation 29 T H O M S O N S C I E N T I F I C INTERVENTIONS –Name [standardized T-Pharma drug name + synonyms] –Role (Primary Intervention, Active Controlcoordinated with named compounds) Intervention Types: Drug Gene Transfer Vaccine Device Procedure Behavior Drug Combination Cell Therapy

Copyright 2008 Thomson Corporation 30 T H O M S O N S C I E N T I F I C Basic data provided by study sponsor enhanced with Thomson Pharma value-added indexing Conditions (sponsors keywords + T-Pharma Indication, Therapeutic category, Action terms)

Copyright 2008 Thomson Corporation 31 T H O M S O N S C I E N T I F I C Data Elements in RED = Value-Added Indexing Point & click search routines developed to retrieve related protocol records Associated Biomarkers Type: Discovery/validation of disease markers Discovery of therapeutic effect markers Measurement of therapeutic effect markers

Copyright 2008 Thomson Corporation 32 T H O M S O N S C I E N T I F I C Adding controlled Ethnicity terms, when applicable + MeSH age groups

Copyright 2008 Thomson Corporation 33 T H O M S O N S C I E N T I F I C Adding standardized TPharma organization names + controlled country names + regional classification

Copyright 2008 Thomson Corporation 34 T H O M S O N S C I E N T I F I C Links to Thomson Pharma Drug & Company Reports + full text of primary source

Copyright 2008 Thomson Corporation 35 T H O M S O N S C I E N T I F I C Thomson Pharma Value-Added Features in Trial Results Reporting & Retrieval… Offers timely access to results of both ongoing and completed phase I-III trials before product approval; phase IV postmarketing trials also included Coverage includes both positive and negative clinical data and is not contingent upon whether official marketing authorization will ever be achieved for a product The Outcomes Reports collection will provide a fully searchable archive of announcements of trial results to support retrospective, as well as current research, inquiries (1994 – present) Information derived from multiple sources (e.g., IDdb Mtg Rpts, press releases, company Web pages) is integrated into each Outcomes Report (iterative, cumulative build), enhanced with links to full-text documents –Benefits: One stop shop saves time otherwise spent in culling data from diverse, fragmented repositories Highly structured Outcomes Reports enable searching of pivotal factors, such as dose ranges, specified adverse effects, etc. –Benefits: Enables high precision search capabilities to pinpoint answers quickly

Copyright 2008 Thomson Corporation 36 T H O M S O N S C I E N T I F I C An entirely new set of index terms was created to facilitate searches on treatment details. Users will be able to view menus of predictable vocabulary for units of measure when searching on dose levels or duration of regimen, plus standardized terms for route & frequency of administration.

Copyright 2008 Thomson Corporation 37 T H O M S O N S C I E N T I F I C Value-add: Tabular summaries of adverse event data + controlled (predictable) vocabulary for events, including AE Category terms

Copyright 2008 Thomson Corporation 38 T H O M S O N S C I E N T I F I C Outcomes Reports integrate & accumulate data derived from multiple sources.

Copyright 2008 Thomson Corporation 39 T H O M S O N S C I E N T I F I C

Copyright 2008 Thomson Corporation 40 T H O M S O N S C I E N T I F I C

Copyright 2008 Thomson Corporation 41 T H O M S O N S C I E N T I F I C

Copyright 2008 Thomson Corporation 42 T H O M S O N S C I E N T I F I C

Copyright 2008 Thomson Corporation 43 T H O M S O N S C I E N T I F I C Option to search specific factors in treatment regimens

Copyright 2008 Thomson Corporation 44 T H O M S O N S C I E N T I F I C Clinical Trial Section Scope – 7.3 Release (Sept ) Protocols & Associated Outcomes Reports for: –Three indications (specific conditions) Alzheimers Rheumatoid Arthritis Diabetes (and its complications) –All three offered as part of basic Thomson Pharma subscription –More than 2,200 reports provided as a working example of the depth & quality of indexing + powerful search capabilities In 2008, extending scope to include coverage of all therapeutic areas currently covered in the Thomson Pharma investigational drug database. Segments for each additional therapeutic area (consisting of both Protocols and Outcomes Reports for all related indications) will be released in a succession of optional add-ons to basic subscription throughout 2008, as indexing in each therapeutic area is completed. –Cardiovascular – March –Neurological – May –Infection – June –Gastrointestinal – August –Immune Disorders - Sept

Copyright 2008 Thomson Corporation 45 T H O M S O N S C I E N T I F I C Whats New? Smart Alerts Designed to capture new associations that would be very difficult to find using standard search techniques –First product patent filed by a company on a new target –First time link of a target with a therapy area on a patent –First third-party patent on any drug –First occurrence of an action term in a patent –First patent filing for a company –First time joint patent filings between two organizations –First time occurrence of an action term on a drug –New chemical structures that have been added to drug reports

Copyright 2008 Thomson Corporation 46 T H O M S O N S C I E N T I F I C How is the Information Displayed? HOMEPAGE: Competitive Intelligence New Portlet: Smart Alerts –Filterable by Therapy Area –Set up alerts

Copyright 2008 Thomson Corporation 47 T H O M S O N S C I E N T I F I C Filter the information by therapy area, patent owner etc. to produce a more refined results list

Copyright 2008 Thomson Corporation 48 T H O M S O N S C I E N T I F I C Whats New? Entelos Reports Entelos Inc., the leader in predictive biosimulation, develops computer models of human physiology and creates virtual patients to optimize pharmaceutical and biotechnology research and development. PhysioLab ® technology is used to test novel interventions, predict efficacy, assess safety, optimize product development, and better position existing products in competitive markets. Entelos Reports provide unique predictive content about a specific biological target. Access Entelos reports from a hot-linked logo on the Thomson Pharma homepage or from the Browse Targets menu Three types of report will be available –Target, Clinical, and Commercial

Copyright 2008 Thomson Corporation 49 T H O M S O N S C I E N T I F I C Overview of the 8.1 release (March 2008) Latest enhancements to Thomson Pharma focus on visualization tools for analysis and streamlined navigation Improved charting/Rank by options Bar charts Pie charts Matrices Star Tree/Hyperbolic Tree visualizations Metadata Fingerprints PLUS another option for current awareness: RSS Feeds

Copyright 2008 Thomson Corporation 50 T H O M S O N S C I E N T I F I C Rank by – Bar Charts New format bar charts –Interactive: click on a chart segment to view corresponding results –More Rank by options, including parent company, originator –Ability to select up to 70 top ranking items per chart –Specify parameters and chose cut-off limits –Option to select a subset of results to drill down and analyze further Benefit: Enables quick detection of patterns within your results and jump to specific subsets identified through ranking

Copyright 2008 Thomson Corporation 51 T H O M S O N S C I E N T I F I C Rank by – Pie Charts Additional visualization option –Interactive chart, click on a segment of the pie to view those specific results –Uses same Rank by options as the bar charts –Ability to chart up to 20 top- ranking items within the data element designated for analysis –Option to select a subset of results to drill down and analyze further Double click on a segment of the pie chart to isolate a specific subset within your search results Hover over a segment to see more details

Copyright 2008 Thomson Corporation 52 T H O M S O N S C I E N T I F I C Rank by – Matrix Display Two-dimensional matrices show relationships within results –Analyse two fields (e.g. action vs. therapy area) at a glance to detect patterns & trends –Interactive chart: click on any number to view those specific records –Color codes: the darker the color, the larger the number of corresponding results –Option to select a subset of results to drill down and analyse further

Copyright 2008 Thomson Corporation 53 T H O M S O N S C I E N T I F I C Star Trees Hyperbolic Trees (Star Trees) –Give you the ability to explore and analyse drug and patent results lists in a new visual form –Allow users to navigate and explore hierarchical relationships and drill-down to information of interest –Fully interactive charts Colour coded Movable, can re-centre around a different point of interest –2 predefined options or The displayed can be moved around to view the chart from different angles Change the display options e.g. colour coding, format Benefit: Allows users to navigate and explore hierarchical relationships and drill-down to information of interest

Copyright 2008 Thomson Corporation 54 T H O M S O N S C I E N T I F I C Metadata Fingerprints Show the content associated with each report Enable you to filter your results by report attributes –Click on a segment to narrow down your results to items containing the selected attribute –Advanced filtering options enable you to exclude, as well as include, designated information in your results list Benefit: Makes it easy for users to determine which reports are of most interest, without having to open them

Copyright 2008 Thomson Corporation 55 T H O M S O N S C I E N T I F I C RSS Feeds Set up RSS feeds out of Thomson Pharma from 8 of the homepage portlets e.g. meetings –Recommended to use either Internet Explorer 7 or Firefox 2 Benefit: Content of Thomson Pharma current awareness portlets can be displayed alongside other news feeds of interest to users

Copyright 2008 Thomson Corporation 56 T H O M S O N S C I E N T I F I C System Requirements In order to benefit from the latest enhancements to Thomson Pharma, and to continue using the rank by function, users must have the following plug-ins installed on their pcs –Java version 1.4 or above –Adobe Flash Player 9 or above These plug-ins are free to download If you do not have the correct plug-in a message will be displayed alerting you to the fact

Copyright 2008 Thomson Corporation 57 T H O M S O N S C I E N T I F I C