Changes in Bowel Movement Supervised by : Prof. Riaz Qureshi Presented by: Rayan AlZuhairi Abdullah AlRajhi Abdullah Aldubaib

Objectives To differentiate between normal and abnormal bowel movements ( constipation and diarrhea ) To know the definition, clinical features, diagnosis and management of Irritable bowel syndrome (IBS). To know the definition, clinical features, diagnosis, management and complications of : Inflammatory bowel disease (crohn and ulcerative colitis) Coeliac disease Lactose intolerance

Test 1-For a 25 - year - old female complaining of chronic constipation for 4 months, the first line treatment is: A- oral laxatives B- refer to GI specialist C-change life style and diet D-IV fluid administration

Test 2- The following are typical symptoms of IBS except : A- abdominal pain improves with defecation. B- onset of abdominal discomfort is associated with changes in normal stool C- progressive abdominal pain D- Change in frequency of stool

Test 3. Which of the following causes symptoms in celiac disease : Gluten protein Lactose Glucose Fats

Test 4. Which of the following diseases has this endoscopic appearance ( vascular marking is lost , petchiae, exudate, touch friability , frank hemorrhage , and the colonic involvement is continuous Ulcerative colitis Crohn disease Celiac disease Lactose intolerance

Test 5. The most common site involved in crohn disease is ? Terminal ileum Colon First part of Duodenum Jejunum

Bowel movement Normal Abnormal Constipation Diarrhea Acute Chronic

Normal bowel movement Definition : Body wastes passed through the rectum and anus. Normally “consist of brown stools, not too hard, not too loose” The fact is that there is no one definition of a normal bowel movement. Many people believe that the definition of a normal bowel movement is having 1 movement each day, but that is not true for everyone.

Frequency of bowel movements There is no rule for frequency of bowel movements, but the general range is from 3 times a day to 3 times a week. “ each person has his own pattern ” Less than 3 movements a week may indicate constipation, and more than 3 watery stools a day could indicate diarrhea.

Pathology of the bowel movement Constipation < 3 movements a week diarrhea > 3 watery stools a day

Constipation

Constipation The definition of constipation includes the following: Infrequent bowel movements (less than three times per week) Difficulty during defecation (straining and a sensation of hard stools that are difficult or painful to pass)

Causes of constipation Insufficient dietary fiber intake or a diet high in fats. Inadequate fluid intake or dehydration. Decreased physical activity. Irritable bowel syndrome. Hypothyroidism. Obstruction by colorectal cancer. Side effects of medications : Pain medications (especially narcotics) Blood pressure medications (calcium channel blockers)

Alarm symptoms (Red flags) Especially in patients over the age of 50: New-onset constipation Anemia Weight loss Rectal bleeding Positive occult blood test Abdominal masses Rectal masses Recommended test: colonoscopy

Management Lifestyle and diet changes (Patient Education): Drinking enough water each day prevents dehydration. exercise is recommended for better overall health There should be enough fiber in your diet Change medications which cause constipation Treat the cause (e.g. Hypothyroidism ) Consider drugs only if above measures fail (laxatives )

When to refer to specialist? Constipation which last for three weeks or more. Never been constipated before, especially 50 years and above Have severe stomach pain. Noticed blood in stool. Losing weight without trying to.

Diarrhea

Diarrhea The definition of diarrhea includes the following: frequent bowel movements (three times or more per day) loose or watery stools

Classification of diarrhea Osmotic diarrhea: means that something in the bowel is drawing water from the body into the bowel such as excessive sugar or excessive salt. Secretory diarrhea:  occurs when the body is releasing water into the bowel when it's not supposed to or if there is an inhibition of absorption. Exudative diarrhea:  refers to the presence of blood and pus in the stool. This occurs with inflammatory bowel diseases

Diagnostic Tests Stool analysis (Occult blood) Blood tests (CBC) Celiac antibodies Colonoscopy in some cases Occasionally, Imaging tests such as X-rays or CT scans

Alarm symptoms (Red flags) Rectal bleeding. Nocturnal or progressive abdominal pain. Weight loss. Laboratory abnormalities such as anemia, elevated inflammatory markers, or electrolyte disturbances. Patients with one of these alarm symptoms require further imaging studies and/or colonoscopy

Management Replacing lost fluids and electrolytes to prevent dehydration Continuing to eat is recommended Antibiotics Anti motility agents

Complications Dehydration Hypotension and syncope in moderate or sever cases Electrolytes imbalance Weakness kidney failure coma

Irritable bowel syndrome Chronic diarrhea Irritable bowel syndrome Inflammatory Bowel Disease Ulcerative colitis Crohn's disease Celiac Disease Lactose intolerance

1- Irritable bowel syndrome Definition: It is a gastrointestinal syndrome characterized by chronic abdominal pain and altered bowel habits in the absence of any organic cause. It is the most commonly diagnosed gastrointestinal condition.

Epidemiology Prevalence of IBS in North America estimated from population-based studies is approximately 10 to 15 % In Europe found an overall prevalence of 11.5 % A study done in Riyadh (2011) revealed that the prevalence of IBS was 11.4% with a significant difference between male and female (8.51% : 14.28%, respectively).

Causes of IBS The causes of IBS are not well understood. Researchers believe a combination of physical and mental health problems can lead to IBS. The possible causes of IBS include the following: Brain-gut signal problems (thalamic activity). Mental health problems (such as anxiety and depression). Gastrointestinal infections.

Clinical Manifestations Chronic abdominal pain or discomfort  Altered bowel habits (diarrhea and constipation) Other gastrointestinal symptoms (as Nausea) Abdominal bloating or distention

Diagnostic Approach “nice guidelines” Consider assessment for IBS if the person reports having had any of the following symptoms for at least 6 months: Abdominal pain or discomfort Bloating Change in bowel habit.

The Rome Criteria Rome III diagnostic criteria: Recurrent abdominal pain or discomfort for at least 3 days per month in the last 3 months, plus 2 or more of the following: Improvement by defecation. Onset associated with change in stool frequency. Onset associated with change in form (appearance) of the stool.

Cont. Symptoms Support The Diagnosis. Altered stool passage (straining, incomplete evacuation “tenesmus”) Symptoms made worse by eating Passage of mucus.

Diagnostic tests In people who meet the IBS diagnostic criteria, the following tests should be undertaken to exclude other diagnoses: Complete blood count (CBC) erythrocyte sedimentation rate (ESR) c-reactive protein (CRP) antibody testing for coeliac disease (endomysial antibodies [EMA] or tissue transglutaminase [TTG]).

Alarm symptoms (Red flags) History : unintentional and unexplained weight loss rectal bleeding a family history of bowel or ovarian cancer clinically examined : anaemia abdominal masses rectal masses inflammatory markers for inflammatory bowel disease. should be referred to secondary care for further investigation if any are present.

Management The main goal of treatment is to decrease the severity of the symptoms and improve quality of life. Non pharmacological Pharmacological

Non pharmacological Patient education: Physical activity : People with IBS should be given information about the importance of lifestyle and dietary modifications in effectively managing their IBS. Healthcare professionals should encourage people with IBS to create relaxation time and to avoid stressful situations. Physical activity : Give people with low activity levels brief advice and counseling to increase their activity.

Dietary modification : Have regular meals and take time to eat. Avoid missing meals or leaving long gaps between eating. Drink at least eight cups of fluid per day, especially water. Reduce intake of alcohol and soft drinks. Possible precipitating substances, such as caffeine, lactose, or fructose, may need to be eliminated from the diet. Symptom monitoring can be helpful to identify precipitating substances and factors.

First-line pharmacological treatment Choose single or combination medication based on the predominant symptom(s) : Consider offering antispasmodic agents(Mebeverine). These should be taken as required alongside dietary and lifestyle advice. Consider offering laxatives for constipation Offer loperamide as the first choice of antimotility agent for diarrhea

Second-line pharmacological treatment Tricyclic antidepressant (TCAs) and Selective serotonin re-uptake inhibitors (SSRIs) : Consider TCAs for their analgesic effect if first-line treatments do not help. Consider SSRIs only if TCAs are ineffective.

Psychological Interventions Should be considered for people with IBS who do not respond to pharmacological treatments after 12 months  Cognitive behavioural therapy Hypnotherapy

Prognosis Patients with IBS have an excellent prognosis in the sense that they have a normal life expectancy, and there are no long-term complications of their disease

When to refer to a specialist? Family history of bowel cancer. Uncertainty of diagnosis. Abnormality on examination or investigation. Anemia Constant abdominal pain. Constant diarrhoea. Constant distension. Rectal bleeding. Weight loss or malaise. Nocturnal pain or diarrhea

Irritable bowel syndrome Chronic diarrhea Irritable bowel syndrome Inflammatory Bowel Disease Ulcerative colitis Crohn's disease Celiac Disease Lactose intolerance

Inflammatory Bowel Disease

What are the main types of inflammatory bowel disease ? Inflammatory Bowel Diseases Crohn’s Disease Ulcerative colitis

Crohn disease Definition : is a chronic transmural inflammatory disease that can affect any part of the GI tract (mouth to anus ) but most commonly involves the small bowel ( terminal ileum ) . Clinical features : It depend on the region involved Diarrhea ( usually without blood ) Malabsorption Abdominal pain (usually right lower quadrant ) , nausea , vomiting Fever , malaise Extra intestinal manifestations ( uveitis , arthristis, akylosis spondylitis , apthatous, ulcer erythema nodosom )

Diagnosis of crohn’s disease Crohn’s disease diagnosis is established with endoscopic findings in a patient with a compatible clinical history Colonoscopy : aphtous ulcers , cobblestone appearance , pseudopolyps , skip lesions . In biopsy :Transmural lesion Stool analysis : fecal calproctein to help distinguish between inflammatory bowel diseases and non-inflammatory bowel diseases (IBS) Antibody tests :, Anti-Saccharomyces cerevisiae antibodies (ASCA) , Antineutrophil cytoplasmic antibodies (pANCA)

Diagnosis of crohn’s disease Inflammatory markers : ESR , CRP Barium enema Upper GI with small bowel follow through Wireless capsule endoscopy

Normal Endoscopic appearance of the bowel

Endoscopic Appearance in crohn’s disease

Complication: Fistulae ( with intestine ,bladder, vagina ,skin ) Anorectal diseases ( fissures, abscess) Small bowel obstruction Malabsorption of Vit b12

Management of crohn’s disease During relapse: During remission : 1. Corticosteroid ( prednisone .. ) : for acute exacerbation 2. Aminosalicylate (Sulfasalazine)5ASA : reduce inflammation More effective in ulcerative colitis 3. Immunosuppresnt (azathioprine ) : not as monotherapy in (combination with steroid ) 4. Methotrexate : not as monotherapy ( in combination with steroid ) 5. Metronidazole 6. Infliximab: for adults with severe active Crohn's disease whose disease has not responded to conventional therapy Corticosteroid ( prednisone.. ) Immunosuppressant (azathioprine ) Methotrexate: in patient who cannot tolerate azathioprine. Surgey : For complication ( ex. Small bowel obstruction )

Admit patient if : Sever abdominal pain associated with tenderness Severe diarrhea more than 8 day Dramatic weight loss Bowel obstruction Fever or signs of systemic disease

Ulcerative colitis Definition : chronic inflammatory disease of the colon or rectal mucosa (almost involve rectum in all cases ) Clinical features : Hema tochezia (bloody diarrhea ) abdominal pain bowel movement are frequent but small fever , anorexia , weight loss extra intestinal manifestations : ( jaundice ,uveitis , arthritis .. )

Diagnosis of ulcerative colitis Diagnosis is based on clinical picture , endoscopy and laboratory Colonoscopy : the vascular marking is lost , petchiae, exudate, touch friability , frank hemorrhage , colonic involvement is continuous in contrast to crohn . Biopsy : crypt abscess ,branching of crypts , atrophy of glands and loss of mucin in goblet cells . Lesion is just in the mucosa . Antibody tests  : Antineutrophil cytoplasmic antibodies (pANCA), Anti-Saccharomyces cerevisiae antibodies (ASCA) 

Diagnosis of ulcerative colitis Stool culture : to rule out infection ( ova ,parasite, colistriduim difficle ) Fecal leucocyte Inflammatory markers : ESR , CRP Stool analysis : fecal calproctein to help distinguish between inflammatory bowel diseases and non-inflammatory bowel diseases(IBS).

Endoscopic and Microscopic appearance of bowel in ulcerative colitis

Complication Iron deficiency anemia Hemorrhage Electrolyte disturbance and dehydration due to diarrhea Colon cancer :ulcerative colitis has higher risk than crohn Sclerosing cholangitis : obstructive jaundice Toxic megacolon : leading cause of death in ulcerative colitis , increase risk of perforation .

Management of ulcerative colitis During relapse : Aminosalicylate (Sulfasalazine) is the main stay for treatment corticosteroid for acute exacerbations During remission : Aminosalicylate (Sulfasalazine) Immunosuprissive agent (azathioprine) if remission is not maintained by aminosalicylates Surgery : for 1. debilitating unresponsive to medical therapy 2. toxic megacolon , perforation , hemorrhages .

Admit if Sever abdominal pain associated with tenderness Severe diarrhea more than 8 times a day Dramatic weight loss Fever more than 37.5 tachycardia more than 90bpm or other signs of systemic disease

Coeliac disease

Coeliac Disease Definition : Is an autoimmune condition characterized by an abnormal jejunal mucosa that improves when gluten ( contained in wheat ,rye and barley ) is withdrawn from diet . Can happen at any age Clinical features : Chronic diarrhea Failure to thrive or faltering growth in children Nausea , vomiting Tiredness Abdominal pain, distention cramping weight loss

Coeliac Disease Diagnosis serological testing: IgA tissue transglutaminase (tTGA) as a first-choice Biopsy : definitive diagnosis (villous atrophy and crypt hyperplasia ) Complication : Malignancy ( intestinal t cell lymphoma, small bowel and esophageal cancer ) Osteoporosis But sticking to gluten free diet decrease complication risk

Management of coeliac disease Diet : gluten free diet add supplements if the patient has deficient nutrient (iron , folic acid , calcium …) Pneumococcal Vaccination: all patient with celiac disease have degree of hyposplenism which make them more prone to pneumococcal infections Follow up : Every 6 -12 month with routine check of symptoms , weight and blood test ( HB , folate , iron ….)

Lactose Intolerance

Lactose intolerance Definition : Lactose intolerance is an inability to digest lactose, the main sugar in milk, that gives rise to gastrointestinal symptoms. is caused by a deficiency of the intestinal enzyme lactase . Can be : Primary : as Normal result of aging for some people Secondary: Result of illness or injury ( celiac , crohn … ) congenital : complete absence of lactase activity in newborn (rare )

Clinical features : The signs and symptoms of lactose intolerance usually begin 30 minutes to two hours after eating or drinking foods that contain lactose. Diarrhea Nausea, and sometimes, vomiting Abdominal cramps Bloating flatulence 

Diagnosis of lactose in tolerance Hydrogen breath test: the most convenient and reliable test. requires drinking lactose containing liquid. Then the amount of hydrogen in breath is tested. Lactose tolerance test: Two hours after drinking a lactose containing liquid, blood tests are done to measure the amount of glucose in your bloodstream. Stool acidity: For infants and children who can't undergo other tests

Management of lactose intolerance Diet: the most obvious means of treating lactose intolerance is by reducing the amount of lactose (dairy products) in the diet. Lactase enzyme: Tablets of lactase are available to take with milk-containing food. Calcium and Vit D supplement

HOME MESSAGES: Irritable bowel syndrome is a chronic condition characterised by abdominal pain associated with bowel dysfunction. The patient will typically have recurrent abdominal pain or discomfort that is associated with a change in stool frequency or form. The pain or discomfort may be relieved by defecation. It is important to determine whether there are any dietary associations such as lactose-containing foods or fructose-containing foods.

HOME MESSAGES: Mind and body often combine to increase the distress of IBS patients. The diagnosis is based on the patient's history, and there are no specific diagnostic tests. Treatment should be individualized and is dependent on the patient's predominant symptoms.

HOME MESSAGES: Psychological intervention worth considering. IBS patients can be managed well by family physicians. Don’t forget “red flags” for referral to GI specialist is a must !

Answers of the Test

Test 1-For a 25 - year - old female complaining of chronic constipation for 4 months, the first line treatment is: A- oral laxatives B- refer to GI specialist C-change life style and diet D-IV fluid administration

Test 1-For a 25 - year - old female complaining of chronic constipation for 4 months, the first line treatment is: A- oral laxatives B- refer to GI specialist C-change life style and diet D-IV fluid administration

Test 2- The following are typical symptoms of IBS except : A- abdominal pain improves with defecation. B- onset of abdominal discomfort is associated with changes in normal stool C- progressive abdominal pain D- Change in frequency of stool

Test 2- The following are typical symptoms of IBS except : A- abdominal pain improves with defecation. B- onset of abdominal discomfort is associated with changes in normal stool C- progressive abdominal pain D- Change in frequency of stool

Test 3. Which of the following causes symptoms in celiac disease : Gluten protein Lactose Glucose Fats

Test 3. Which of the following causes symptoms in celiac disease : Gluten protein Lactose Glucose Fats

Test 4. Which of the following diseases has this endoscopic appearance ( vascular marking is lost , petchiae, exudate, touch friability , frank hemorrhage , and the colonic involvement is continuous Ulcerative colitis Crohn disease Celiac disease Lactose intolerance

Test 4. Which of the following diseases has this endoscopic appearance ( vascular marking is lost , petchiae, exudate, touch friability , frank hemorrhage , and the colonic involvement is continuous Ulcerative colitis Crohn disease Celiac disease Lactose intolerance

Test 5. The most common site involved in crohn disease is ? Terminal ileum Colon First part of Duodenum Jejunum

Test 5. The most common site involved in crohn disease is ? Terminal ileum Colon First part of Duodenum Jejunum

Abdominal Examination https://www.youtube.com/watch?v=rKlSK4628mI

References http://www.nice.org.uk/guidance/topic Oxford Hand book of general practice 3rd edition – Simon / Everitt / Dropp Step up to medicine -2d edition – Agabegi Essential of clinical medicine – 5th edition – Kumar & Clarks http://www.mayoclinic.com http://www.etlibrary.org/?m=fbook&a=details&aid=4272 http://ibdcrohns.about.com/od/dailylife/a/normalbm.htm http://www.romecriteria.org/assets/pdf/19_RomeIII_apA_885-898.pdf