2. Irritable Bowel Syndrome 1481 Nadeem Khan March 2, 2015

3. Introduction  First described in 1771.  50% of patients present <35 years old.  70% of sufferers are symptom free after 5 years.  GPs will diagnose one new case per week.  GPs will see 4-5 patients a week with IBS.  Point prevalence of 40-50 patients per 2000 patients. 2

4. What Is IBS?  A syndrome.  One man’s constipation is another man’s normality.  Cause unknown.  20% seem to start after an episode of gastroenteritis. 3

5. EPIDEMIOLOGY OF IBS 4

6. IBS: A Multidimensional Disorder  BIOLOGICAL  PSYCHOLOGICAL  BEHAVIORAL 5

7.  Symptoms compatible with IBS are present in 7-15% of the general population Females predominate 2:1. Most of the people who meet diagnostic criteria for IBS have never consulted a doctor for bowel symptoms (IBS nonpatients). 6

8. Diagnostic Criteria  Rome 11 Diagnostic criteria.  Manning’s Criteria. 7

9. Rome 11 Diagnostic Criteria.  At least 12 weeks history, which need not be consecutive in the last 12 months of abdominal discomfort or pain that has 2 or more of the following:  Relieved by defecation.  Onset associated with change in stool frequency.  Onset associated with change in form of the stool. 8

10. Rome 11 Diagnostic Criteria.  Supportive symptoms.  Constipation predominant: one or more of:  BO less than 3 times a week.  Hard or lumpy stools.  Straining during a bowel movement.  Diarrhoea predominant: one or more of:  More than 3 bowel movements per day.  Loose [mushy] or watery stools.  Urgency. 9

11. Rome 11 Diagnostic Criteria.  General:  Feeling of incomplete evacuation.  Passing mucus per rectum.  Abdominal fullness, bloating or swelling. 10

12. Manning’s Criteria.  Three or more features should have been present for at least 6 months:  Pain relieved by defecation.  Pain onset associated with more frequent stools.  Looser stools with pain onset.  Abdominal distension.  Mucus in the stool.  A feeling of incomplete evacuation after defecation. 11

13. Associated Symptoms  In people with IBS in hospital OPD.  25% have depression.  25% have anxiety.  Patients with IBS symptoms who do not consult doctors [population surveys] have identical psychological health to general population.  In one study 70% of women IBS sufferers have dyspareunia. 12

14. Associated Symptoms  Stressful life events are associated.  Compared with controls people with IBS are less well educated and have poorer general health.  Women:Men = 3:1. 13

15. Reasons to Refer  Age > 45 years at onset.  Family history of bowel cancer.  Failure of primary care management.  Uncertainty of diagnosis.  Abnormality on examination or investigation. 14

16. Urgent Referral  Constant abdominal pain.  Constant diarrhoea.  Constant distension.  Rectal bleeding.  Weight loss or malaise. 15

17. Subtypes  Diarrhoea predominant.  Constipation predominant.  Pain predominant. 16

18. Differential Diagnosis  Inflammatory bowel disease.  Cancer.  Diverticulosis.  Endometriosis.  A positive diagnosis, based on Manning’s criteria may provoke less anxiety than extensive tests. 17

19. Examination  Results should be normal or non-specific.  Abdomen and rectal examination.  FBC, CRP.  No consensus as to whether FOBs or sigmoidoscopy is needed. 18

20. Treatment  Patients’ concerns.  Explanation.  Treatment approaches. 19

21. Patients’ Concerns.  Usually very concerned about a serious cause for their symptoms.  Take time to explore the patients agenda.  Remember that investigations may heighten anxiety. 20

22. Explanation.  Must offer a plausible reason for symptoms.  Even if cause is unknown, patients require some explanation.  Drawing a parallel with baby colic may help.  Stress is currently a socially acceptable explanation for many symptoms in life. 21

23. Treatment Approaches.  Placebo effect of up to 70% in all IBS treatments.  Treatment should depend on symptom sub-type.  Often considerable overlap between sub- groups. 22

24. Antidepressants  Poor evidence for efficacy.  Better evidence for tricyclics.  Very little evidence for SSRIs. 23

25. Diarrhoea Predominant.  Increasing dietary fibre is sensible advice.  Fibre varies, 55% of patients will get worse with bran.  “Medical fibre” adds to placebo effect.  Loperamide may help. 24

26. Constipation Predominant.  Increased fibre.  Osmotic laxatives helpful. Ispaghula husk is one.  Stimulant laxatives make symptoms worse.  Lactulose may aggravate distension and flatulence. 25

27. Pain Predominant.  Antispasmodics will help 66%.  Mebeverine is probably first choice.  Hyoscine 10mg qid can be added.  Bloating may be helped by peppermint oil.  Nausea may require metoclopramide. 26

28. Diet  Dietary manipulation may help.  Food intolerance is common food allergy is rare.  Relaxation therapies may be useful adjunct. 27

29. Referral  About 15% of patients seen by GPs with IBS are referred.  Gastroenterology – Mainly upper GI symptoms.  General Surgical – Lower GI symptoms. 28

30. Audit?  Numbers on repeat prescription for anti- spasmodics.  Do they use their drugs as prescribed?  What other medications do they use?  Referral rates?  What investigations are done?  Protocol?  Formulary? 29

31. Psychological Thoughts  Should a mental health assessment always be done?  Should all therapy be directed at psychological causes?  Is IBS a physical or a somatisation disorder? 30

32. Self-help  IBS network, St John’s House, Hither Green Hospital, Hither Green Lane, London SE13 6RU 31