Gene therapy. Lecture Plan 1.Molecular Medicine and Gene Therapy: An Introduction 2.Vectors in Gene Therapy 1.Viral vector of gene therapy 2.Non viral.

Slides:



Advertisements
Similar presentations
Insertion of Fragments of DNA: Gene Disruption and Replacement.
Advertisements

Option F: Microbes and Biotechnology F.3 Microbes and Biotechnology.
Zeroing in on Non-Small Cell Lung Cancer: Integrating Targeted Therapies into Practice.
Cancer Genetics Is Cancer a Genetic Disease? Cancer is not a classic genetic disease, instead, Genetic background (set-up) has a definite role in cancer.
One good example of considering gene expressions at the review for approval Taxol: Indicated for the adjuvant treatment of node- positive breast cancer.
Cancer Gene Therapy …Using Tumor Suppressor Genes.
 MicroRNAs (miRNAs) are a class of small RNA molecules, about ~21 nucleotide (nt) long.  MicroRNA are small non coding RNAs (ncRNAs) that regulate.
Gene therapy progress and prospects cancer. Gene Therapy Primary challenge for gene therapy – Successfully delivery an efficacious dose of a therapeutic.
In Search of the Sickle Cell Gene Terry Kotrla, MS, MT(ASCP)BB Spring 2010.
Geonomics in Breast Cancer Decoding Human Genome Luis Barreras, M.D., FACP.
Joakim Dillner, M.D. Professor Department of Laboratory Medicine Karolinska Institutet Sweden Karolinska Institutet.
Molecular & Genomic Pathology in the Management of Cancer: Teaching...Who, When, What and How Antonia R. Sepulveda MD., PhD Columbia University, NY, NY.
Metastatic Breast Cancer: One Size Does Not Fit All Clifford Hudis, M.D. Chief, Breast Cancer Medicine Service MSKCC.
P53 has a key role in integrating the cellular responses (pink boxes) to different types of stress (blue boxes). Activation of p53 can result in a number.
Long-Term Follow-Up of Subjects in Gene Transfer Clinical Protocols Vector Classes with Potential for Long-Term Risks Carolyn A. Wilson, Ph.D. Division.
KEY CONCEPT Genetics provides a basis for new medical treatments.
Gene Therapy Correcting defective genes. Definition & history  Normal gene inserted into the genome to replace non-functional gene  Trials began in.
Molecular Medicine and Gene Therapy. Monogenetic Disorders – Single gene pathway – Multi gene pathway: But one gene only mutated Multifactorial Disorder.
Cancer Estimated US Cancer Cases Cancer Incidence Rates for Women, USA.
Jo Anne Zujewski, MD Cancer Therapy Evaluation Program Division of Cancer Diagnosis and Treatment National Cancer Institute May 2011 Breast Cancer Biology.
Following genes to health  “One of the first duties of the physician is to educate the masses not to take medicine”.  Sir William Osler  Aphorisms.
FUNCTIONAL GENOMICS REVEAL THAT THE SERINE SYNTHESIS PATHWAY IS ESSENTIAL IN BREAST CANCER Introduction: Tim Butler Spellman Lab.
Powerpoint Templates Page 1 Powerpoint Templates Gene therapy for melanoma By Mohammed razeeth.S.
Therapeutic miRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model Janaiah Kota,1 Raghu R. Chivukula,2 Kathryn A. O’Donnell,3,4 Erik A.
GeneGroupAnalysis BetaCS Alejandro Quiroz-Zárate John Quackenbush lab
Gene therapy for cystic fibrosis. 1.The possibility of replacing a defective gene with a ‘good’ copy of the gene to overcome the problems caused by the.
KEY CONCEPT Genetics provides a basis for new medical _____________.
What is Cancer??. Cancer The name for disease(s) in which the body's cells become abnormal and uncontrollably divide.
Lecture 28 Genetics of Cancer Copyright © 2010 Pearson Education Inc.
BIOLOGY CONCEPTS & CONNECTIONS Fourth Edition Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Neil A. Campbell Jane B. Reece Lawrence.
Gene therapy and Viral Vectors Lecture 6. Contents Introduction to gene therapy Delivery of Therapeutic Genes Gene Therapy Targets Delivery Modes Steps.
Gene therapy and viral vectors
Retroviral Gene Therapy. What is Gene Therapy? Gene Therapy Strategies.
IN CANCER MOLECULAR DETECTION. WHAT DO THEY DETECT? Specific proteins Expression of certain genes Mutations Epigenetic Changes.
Gene Therapy (I) “Introduction to Gene Therapy”
In most gene therapy studies, a "normal" gene is inserted into the genome to replace an "abnormal," disease-causing gene. A carrier molecule called a.
Gene Therapy Mostafa A. Askar NCRRT By M.Sc. In Molecular Biology
Medical Biology By Professor: Ali Abdul Hussein S. AL-Janabi Dept. of Clinical laboratories, Collage of AMS, University of Karbala, Iraq
New research areas in personalised medicines
THE GENETIC BASIS OF CANCER
Karyotyping Cancer.
Gene Therapy: Molecular Biology
International Journal of Medical Biotechnology & Genetics
Presented By Michael Lee at 2016 ASCO Annual Meeting
Dr. Peter John M.Phil, PhD Atta-ur-Rahman School of Applied Biosciences (ASAB) National University of Sciences & Technology (NUST)
Production and clinical development of nanoparticles for gene delivery
Correcting defective genes
سرطان الثدي Breast Cancer
Molecular Basis Of Cancer
The Genomics of Cancer and Molecular Testing:
Relationship between Genotype and Phenotype
KEY CONCEPT Genetics provides a basis for new medical treatments.
Dan Gordon  Gastroenterology  Volume 114, Issue 4, (April 1998)
Optimizing Targeted Therapy for HER2-Positive Advanced Breast Cancer: First-line Considerations.
Cancer stem cells and their application into targeted therapy for cancer Mol. Bio. Lab Park Ji Won Supervisor ; Dae Youn Hwang.
KEY CONCEPT Genetics provides a basis for new medical treatments.
Targeted Therapeutics
KEY CONCEPT Genetics provides a basis for new medical treatments.
Optimizing Targeted Therapy for HER2-Positive Advanced Breast Cancer: Considerations for Previously Treated Disease.
Molecular Therapy  Volume 7, Issue 5, (May 2003) DOI: /S (16)
847. Eradication of Therapy-Resistant Human Prostate Tumors Using an Ultrasound Guided Site-Specific Cancer Terminator Virus Delivery Approach    Molecular.
KEY CONCEPT Genetics provides a basis for new medical treatments.
KEY CONCEPT Genetics provides a basis for new medical treatments.
Molecular Therapy - Nucleic Acids
420, , , ,000 1,300,000 One commercial 680, , ,000 1,200,000 1,800,000 Two commercial 680,000.
Molecular Therapy  Volume 21, Pages S247-S248 (May 2013)
420, , , ,000 1,300,000 One commercial 680, , ,000 1,200,000 1,800,000 Two commercial 680,000.
KEY CONCEPT Genetics provides a basis for new medical treatments.
Shirley Wong, Roderick A. Slavcev
One potential implementation for the use of outlier kinase profiling and targeting for clinical management of pancreatic cancer in a precision medicine.
Presentation transcript:

Gene therapy

Lecture Plan 1.Molecular Medicine and Gene Therapy: An Introduction 2.Vectors in Gene Therapy 1.Viral vector of gene therapy 2.Non viral vector of gene therapy 3.Gene Targeting 4.Cancer genes and the pathways they control 5.The Genetic Basis of Cancer 6.Gene therapy progress and prospects cancer 7.Tumor Suppressor Gene Replacement for Cancer 8.Antisense Technology 9.Receptor directed molecular conjugates for gene transfer 10.Conditional gene targeting for cancer gene therapy 11.Pharmacogenetics of breast cancer therapies 12.Hypoxia targeting gene expression for breast cancer gene therapy 13.Gene expression profiling: Decoding breast cancer 14.Ethical issues in Molecular Medicine and Gene Therapy 15.Epilogue: Personal Genetic Medicine—The Future Is Now 16.Term paper: Commercial Implications of gene therapy