1. The Genomics of Cancer and Molecular Testing:

2. Introduction

3. Precision Medicine: A Paradigm Shift

4. Inverted Pyramid: Biomarker-driven Trials

5. Selected Early-Phase Clinical Trials of Targeted Therapies Using Molecular Matching: Response Rates

6. The Genetic Code

7. Oncogenes

8. Tumor Suppressors

9. Types of Mutations

12. Copy Number Alterations

13. Copy Number Alterations (cont)

14. Chromosomal Fusions/Translocations/ Rearrangements

15. Somatic vs Germline Mutations

16. Genomic Alterations: Challenges in Applying the Data

18. Determining Whether a Genomic Alteration is Actionable

19. Definitions

20. Responses With Targeted Therapy

21. Unique Molecular Signatures

22. Standard Markers According to Tumor Type

24. Multiple Gene Alterations: Lessons From Super-responders (Patient 1) - Results from NGS

25. Multiple Gene Alterations: Lessons From Super-Responders (Patient 1)

26. Lessons From Super-Responders: Triple Combo Therapy-Case Study (Patient 2)

27. Response to Triple Combination Therapy

28. Clinical Experience: Lessons Learned

29. Overcoming Resistance: Identifying Precise Alterations

30. Response to Combination of Erlotinib and Cetuximab in a Patient With NSCLC

31. Future Approaches

32. Key Features of Next Generation Trials

33. Abbreviations

34. Abbreviations (cont)

35. Abbreviations (cont)

36. Abbreviations (cont)

37. References

38. References (cont)

39. References (cont)

40. References (cont)