Publication Cho, E., et al., Alcohol Intake and Colorectal Cancer: A Pooled Analysis of 8 Cohort Studies. Annals of Internal Medicine, 2004; 140: 603-613.

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Presentation transcript:

Publication Cho, E., et al., Alcohol Intake and Colorectal Cancer: A Pooled Analysis of 8 Cohort Studies. Annals of Internal Medicine, 2004; 140:

Sweden Mammography Cohort Nurses’ Health Study Netherlands Cohort Study New York State Cohort Iowa Women’s Health Study Canadian National Breast Screening Study Cohort Studies in the Pooled Analysis of Alcohol and Colorectal Cancer Alpha-Tocopherol Beta- Carotene Cancer Prevention Study Health Professionals Follow-up Study Cho, et al., 2004 Total = 489,979 # of cases = 4,687

Cohort Studies in the Pooled Analysis of Alcohol and Colorectal Cancer Study Total # of cohort cases ATBC 26, Canadian National Breast 56, Screening Study Health Professionals 47, Follow-up Study Iowa Women’s Health Study 34, Netherlands Cohort Study 120, New York State Cohort 52, Nurses’ Health Study (a) 88, Nurses’ Health Study (b) 68, Sweden Mammography Cohort 61, Cho, et al., 2004

Total Alcohol Intake Study % Drinkers Mean* (SD) (g/d) ATBC (21.8) Canadian National (14.5) Health Professionals (16.1) Iowa Women’s (12.3) Netherlands Study (W)688.5 (10.6) Netherlands Study (M) (16.7) New York State Cohort (W) (9.4) New York State Cohort (M) (17.1) Nurses’ Health Study (a)689.4 (11.6) Nurses’ Health Study (b)649.6 (12.1) Sweden Mammography Cohort673.5 (3.5) *Among drinkers only Cho, et al., 2004

Alcohol and Colorectal Cancer Intake No. of Multivariate RR (g/d)cases(95% CI) 01, (ref) >0-<51, ( ) 5-< ( ) 15-< ( ) 30-< ( ) > ( ) P for trend <0.001 Cho, et al., 2004

Study-Specific Relative Risks for Colorectal Cancer for Alcohol Intake > 30 vs. 0g/d Cho, et al., 2004

Alcohol Intake and Colorectal Cancer by Tumor Site RR (95% CI) Intake (g/d) Colon Rectum >0 - < < < < > ( ) ( ) P for trend < Cho, et al., 2004

Alcoholic Beverages and Colorectal Cancer Intake BeerWineLiquor (g/d) >0-< > ( ) ( ) ( ) P for trend Cho, et al., 2004

Alcoholic Beverages and Colorectal Cancer by Tumor Site Alcoholic Tumor RR (95% CI) beverage site(>15 vs. 0 g/d) Beer Colon1.38 ( ) Rectum1.59 ( ) Wine Colon1.33 ( ) Rectum1.55 ( ) Liquor Colon1.06 ( ) Rectum1.10 ( ) For each beverage, the differences by tumor site were not statistically significant. Cho, et al., 2004

Alcohol and Colorectal Cancer by Body Mass Index P for interaction=0.03 * *P<0.05 Relative Risk 0 >0- 30 Cho, et al., 2004 BMI <2222-<2525+ kg/m 2 Alcohol (g/d)

Alcohol and Colorectal Cancer by Multivitamin Use P for interaction >0.2 * *P<0.05 Relative Risk Alcohol (g/d) 0 >0- 30 Cho, et al., 2004 Nonusers Users