1. Nurses' Health Study: Risk of hypertension associated with >1000 µg/day of folate vs <200 µg/day
Cohort
Absolute risk reduction (cases per 1000 person-years)
Multivariate relative risk reduction
(95% CI)
p for trend
NHS II
(age 26-46) 8
0.54
( )
<0.001
NHS I
(age 43-70) 6
0.82
( )
0.05
Forman JP et al. JAMA 2005; 293:

2. Nurses' Health Study: Risk of hypertension associated with >800 µg/day of supplemental folate vs <200 µg/day among women with dietary intake <200 µg/day
Cohort
Multivariate risk reduction (95% CI)
p for trend
NHS II
(age 26-46)
0.55
( )
0.03
NHS I
(age 43-70)
0.61
( )
0.05
Forman JP et al. JAMA 2005; 293: