The Plague. a little bit o’ history… aka- The Black Death 14 century Europe Killed 1/3 of population.

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Presentation transcript:

The Plague

a little bit o’ history… aka- The Black Death 14 century Europe Killed 1/3 of population

a nursery rhyme? Ring around the rosies -> symptomatic red patches on the skin Pocket full of posies -> people would carry roses in their pockets in attempts to ward off the disease Ashes, Ashes -> burn the dead bodies We all fall down -> 1/3 of the population dead

so what caused the Plague? i’m glad you asked! Yersinia pestis – Gram negative bacteria – Rod shaped – Facultative anaerobe

and how does one get this? Transmitted directly by flea bites warfare/plague_files/image001.jpg

so how is it so deadly?

virulence factors aye? Virulence factors are located on multiple plasmids – Yops – F1

so how do i know if i have it? Symptoms develop abruptly in 1-6 days Sudden: – High fever – Patchy bleeding (rash) under the skin [DIC] – Large lymph nodes – DIC – Bloody sputum – shock

is this treatable? In 14c Europe: NOPE But today… – Tetracycline within hours of fever onset – Vaccine Rat control

so does the plague still exist?

References MICROBIOLOGY: A Human Perspective, sixth edition. Nester