Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC 2004. Lecture 2: Neuroscience Basics 1 Computational Architectures in Biological.

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Presentation transcript:

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 1 Computational Architectures in Biological Vision, USC, Fall 2004 Lecture 2: Neuroscience Basics. Reading Assignments: None

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 2 Central vs. Peripheral Nervous System The brain is not the entire nervous systems; there is also the spinal cord, many peripheral “ganglia” (small clusters of neurons), and neurons extend connections to locations all over the body (e.g., sensory neurons, motor neurons).

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 3 Autonomic Nervous System

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 4

5 Axes in the brain

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 6 Medical Orientation Terms for Slices

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 7 Main Arterial Supply to the Brain

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 8 Arterial Supply is Segmented Occlusion/damage to one artery will affect specific brain regions. Important to remember for patient studies.

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 9 Ventricular System Ventricules: Cavities filled with fluid inside and around the brain. One of their functions is to drain garbage out of the brain.

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 10 Cortical Lobes Sulcus (“fissure” if very large): Grooves in folded cortex Gyrus: cortex between two sulci 1 sulcus, many sulci; 1 gyrus, many gyri

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 11

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 12

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 13

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 14

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 15

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 16

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 17 Neurons Cell body (soma): where computation takes place Dendrites: input branches Axon: unique output (but may branch out) Synapse: connection between presynaptic axon and postsynaptic dendrite (in general).

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 18 Electron Micrograph of a Real Neuron

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 19 Grey and White Matters Grey matter: neurons (cell bodies), at outer surface of brain White matter: interconnections, inside the brain Deep nuclei: clusters of neurons deep inside the brain

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 20 Major Functional Areas Primary motor: voluntary movement Primary somatosensory: tactile, pain, pressure, position, temp., mvt. Motor association: coordination of complex movements Sensory association: processing of multisensorial information Prefrontal: planning, emotion, judgement Speech center (Broca’s area): speech production and articulation Wernicke’s area: comprehen- sion of speech Auditory: hearing Auditory association: complex auditory processing Visual: low-level vision Visual association: higher-level vision

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 21 Major Functional Areas

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 22

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 23

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Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 25

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 26

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 27

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 28

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 29

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 30

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 31 Limbic System Cortex “inside” the brain. Involved in emotions, sexual behavior, memory, etc (not very well known)

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 32 “Flat map” representation Goal: unfold all circonvolutions in cortex, so that exposed as well as usually unexposed (in sulci) areas are well visible.

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 33 Flat Map of Monkey Brain Note how the monkey brain has less developed frontal lobe and fewer circonvolutions (grooves) than human brain.

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 34 Use of Flat Maps: Visual Cortex Mapping Brain activity as seen on brain slices is difficult to put together into brain areas…

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 35 Use of Flat Maps: Visual Cortex Mapping but becomes much easier with at least partial unfolding…

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 36 Comparison Across Species Frontal cortex most developed in humans. Relatively speaking, association areas (involved with more complex / higher-level processing) are larger in humans, compared to primary (sensory, motor, visual, etc) areas.

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 37 Major Functional Areas (other source)

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 38 Visual Input to the Brain

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 39 Human Visual System

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 40 Primary Visual Pathway

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 41 Layered Organization of Cortex Cortex is 1 to 5mm-thick, folded at the surface of the brain (grey matter), and organized as 6 superimposed layers. Layer names: 1: Molecular layer 2: External granular layer 3: External pyramidal layer 4: internal granular layer 5: Internal pyramidal layer 6: Fusiform layer Basic layer functions: Layers 1/2: connectivity Layer 4: Input Layers 3/5: Pyramidal cell bodies Layers 5/6: Output

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 42 Layered Organization of Cortex

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 43 Slice through the thickness of cortex

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 44 Columnar Organization Very general principle in cortex: neurons processing similar “things” are grouped together in small patches, or “columns,” or cortex. In primary visual cortex… as in higher (object recognition) visual areas… and in many, non-visual, areas as well (e.g., auditory, motor, sensory, etc).

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 45 Retinotopy Many visual areas are organized as retinotopic maps: locations next to each other in the outside world are represented by neurons close to each other in cortex. Although the topology is thus preserved, the mapping typically is highly non- linear (yielding large deformations in representation). Stimulus shown on screen… and corresponding activity in cortex!

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 46 Neurons and Synapses

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 47 Transmenbrane Ionic Transport Ion channels act as gates that allow or block the flow of specific ions into and out of the cell.

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 48 Gated Channels A given chemical (e.g., neurotransmitter) acts as ligand and gates the opening of the channel by binding to a receptor site on the channel.

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 49 Action Potential At rest, the inside of the cell rests at a negative potential (compared to surroundings) Action potential consists of a brief “depolarization” (negative rest potential decreases to zero) followed by “repolarization” (inside of membrane goes back to negative rest potential), with a slight “hyperpolarization” overshoot before reaching rest.

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 50 Action Potential and Ion Channels Initial depolarization is due to opening of sodium (Na+) channels Repolarization is due to opening of potassium (K+) channels Hyperpolarization happens because K+ channels stay open longer than Na+ channels (and longer than necessary to exactly come back to resting potential).

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 51 Channel activations during action potential

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 52 Saltatory Conduction along Myelinated Axons Schwann cells wrap around axons, yielding an insulating myelin sheet except at regularly spaces locations (nodes of Ranvier). Provides much faster conduction of action potentials.

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 53

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 54

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 55 Felleman & Van Essen, 1991 Interconnect

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 56 Interconnect… (other source)

Laurent Itti: CS599 – Computational Architectures in Biological Vision, USC Lecture 2: Neuroscience Basics 57 More on Connectivity