2. Nervous System Reflexes and Action Potential

3. How do cells detect and respond to changes in their internal and external environment to successfully survive and maintain homeostasis?

4. 1)Detection of signals from the outside environment or detection of deviation (change) from homeostasis from the internal environment.

5. 2) Integration of multiple signals from outside and inside to produce appropriate response. BRAIN

6. 3) Response to counteract stimulus being detected. Draw your own picture to represent RESPONSE

7. 1)Detection of signals from outside environment or detection of deviation (change) from homeostasis from internal environment. 2)Integration of multiple signals from outside and inside to produce appropriate response. 3)Response to counteract stimulus being detected System builds a Reflex Arc

8. Sensor Receptor (Detection) Sensory Input Integration Effector (Response) Motor Output Peripheral Nervous System (PNS) Central Nervous System(CNS)

9. Spinal Reflexes Mono synaptic reflexes do not reach higher brain levels before responding. –No thought involved –1 synapse (sensory to motor – no interneuron) –Example: sneezing Polysynaptic reflexes reach the brain during response. –More than 1 synapse (sensory to interneuron to motor) –Example- finger on hot stove

10. Reflex test Try the knee-jerk reflex yourself. –Do you have any voluntary control? Can you find any other places on your body that have a similar reflex? –What do the knee-jerk and other reflex spots have in common?

12. Action Potential – Resting I Resting Potential (-70mV) –Result of unequal distribution of ions –Ion channels –Na+ & K+ (mostly) 10X more Na+ outside than inside Na+/K+ Pump “At its most basic, an action potential is a very rapid swing in the polarity of the membrane potential from negative to positive and back, the entire cycle lasting a few milliseconds” (http://en.wikipedia.org/wiki/Action_potential )http://en.wikipedia.org/wiki/Action_potential Animation 

13. Action Potential!!!!!!!!!! Stimulus causes Na+ channels to open –Flow into cell causes depolarization –Adjacent region subsequently depolarized –Voltage climbs to +30 or more Repolarization –Diffusion of K+ out K+ channels –closing of Na + channels All this, 1/1000 sec!

14. Action Potential – Resting II Concentration Gradient 3 Na+ vs. 2 K+ Plasma Membrane more permeable to K+ –Leak out

16. Animation

17. All or none! Threshold Stimulus = -55 mV Subthreshold – those stimuli that are weaker than threshold (No AP) –Summation

18. Action Potential III How does the myelin sheath improve conductance speed? Answer – Blocks the continuous flow of ions through the membraneAnswer – Blocks the continuous flow of ions through the membrane Saltatory Conduction – impulse jumps! between Nodes of Ranvier Saltatory Conduction – impulse jumps! between Nodes of Ranvier

19. http://bcs.whfreeman.com/thelifewire/conte nt/chp44/4402002.htmlhttp://bcs.whfreeman.com/thelifewire/conte nt/chp44/4402002.html

21. Synaptic Gap Junction between neurons from presynaptic neuron to postsynaptic neuron Synaptic vesicles at bulb (end of axon) contain neurotransmitters Synapse Movie

23. The point of contact at which impulses are passed from one cell to another are known as THE SYNAPTIC CLEFT OR SYNAPSE. Neurons that transmit impulses to other neurons DO NOT actually touch one another. The Small Gap or Space between the axon of one neuron and the dendrites of the next neuron is called the Synapse. One importance of the presence of Synapses is that they ensures one-way transmission of impulses in a living person. The Axon Terminals at a Synapse contain tiny vesicles, or sacs. These are known as NEUROTRANSMITTERS.

25. NEUROTRANSMITTER is a chemical substance that is used by one neuron to signal another. The impulse is changed from an Electrical Impulse to a Chemical Impulse (Electrochemical Impulses).