Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings PowerPoint ® Lecture Slide Presentation prepared by Christine L. Case M I C R O B I O L O G Y a n i n t r o d u c t i o n ninth edition TORTORA  FUNKE  CASE Part A 23 Microbial Diseases of the Cardiovascular and Lymphatic Systems

Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings The Cardiovascular System and Lymphatics System  Blood: Transports nutrients to and wastes from cells.  WBCs: Defend against infection.  Lymphatics: Transport interstitial fluid to blood.  Lymph nodes: Contain fixed macrophages.

Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings The Cardiovascular System Figure 23.1

Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings The Lymphatic System Figure 23.2

Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Sepsis and Septic Shock  Sepsis: Bacteria growing in the blood  Severe sepsis: Decrease in blood pressure  Septic shock: Low blood pressure cannot be controlled Figure 23.3

Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Sepsis  Gram-negative sepsis  Endotoxins caused blood pressure decrease.  Antibiotics can worsen condition by killing bacteria.  Gram-positive sepsis  Nosocomial infections  Staphylococcus aureus  Streptococcus pyogenes  Group B streptococcus  Enterococcus faecium and E. faecalis

Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Sepsis  Puerperal sepsis (childbirth fever)  Streptococcus pyogenes  Transmitted to mother during childbirth by attending physicians and midwives.

Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Bacterial Infections of the Heart  Endocarditis: Inflammation of the endocardium  Subacute bacterial endocarditis: Alpha-hemolytic streptococci from mouth  Acute bacterial endocarditis: Staphylococcus aureus from mouth  Pericarditis: Streptococci

Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Bacterial Infections of the Heart Figure 23.4

Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Rheumatic Fever  Inflammation of heart valves  Autoimmune complication of Streptococcus pyogenes infections Figure 23.5

Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Tularemia  Francisella tularensis, gram-negative rod  Transmitted from rabbits and deer by deer flies.  Bacteria reproduce in phagocytes. Figure 23.6

Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Brucellosis (Undulant Fever)  Brucella, gram-negative rods that grow in phagocytes.  B. abortus (elk, bison, cows)  B. suis (swine)  B. melitensis (goats, sheep, camels)  Undulating fever that spikes to 40°C each evening.  Transmitted via milk from infected animals or contact with infected animals.

Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Anthrax  Bacillus anthracis, gram-positive, endospore-forming aerobic rod  Is found in soil.  Cattle are routinely vaccinated.  Treated with ciprofloxacin or doxycycline.  Cutaneous anthrax  Endospores enter through minor cut  20% mortality

Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Anthrax  Gastrointestinal anthrax  Ingestion of undercooked food contaminated food  50% mortality.  Inhalational anthrax  Inhalation of endospores.  100% mortality. Figure 23.7