1. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings PowerPoint ® Lecture Slide Presentation prepared by Christine L. Case Microbiology B.E Pruitt & Jane J. Stein AN INTRODUCTION EIGHTH EDITION TORTORA FUNKE CASE Chapter 23, part B Microbial Diseases of the Cardiovascular and Lymphatic Systems

2. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings 1346Plague-ridden bodies used by Tartar army against Kaffa 1925Plaque-carrying flea bombs used in the Sino-Japanese War 1950sU.S. Army spraying of S. marcescens to test weapons dispersal 1972International agreement to not possess biological weapons 1979B. anthracis weapons plant explosion in the Soviet Union 1984S. enterica used against the people of The Dalles 2001B. anthracis distributed in the U.S. Biological Weapons

3. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Biological Weapons BacteriaViruses Bacillus anthracis“Eradicated” polio and measles Brucella spp.Encephalitis viruses Chlamydia psittaciHermorrhagic fever viruses Clostridium botulinum toxinInfluenza A (1918 strain) Coxiella burnettiMonkeypox Francisella tularensisNipah virus Rickettsia prowazekiiSmall pox Shigella spp.Yellow fever Vibrio cholerae Yersinia pestis

4. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Ischemia Loss of blood supply to tissue Necrosis Death of tissue Gangrene Death of soft tissue Gas gangrene Clostridium perfringens, gram-positive, endospore- forming anaerobic rod, grows in necrotic tissue Treatment includes surgical removal of necrotic tissue and/or hyperbaric chamber Gangrene

5. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Pasteurella multocida Clostridium Bacteroides Fusobacterium Bartonella hensellae Cat-scratch disease Animal bites and scratches

6. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Yersinia pestis, gram-negative rod Reservoir Rats, ground squirrels, prairie dogs Vector Xenopsylla cheopsis Bubonic plague Bacterial growth in blood and lymph Septicemia plague Septic shock Pneumonic plague Bacteria in the lungs Plague

7. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Plague Figure 23.10, 11

8. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Borrelia spp., spirochete Reservoir Rodents Vector Ticks Successive relapses are less severe Relapsing Fever

9. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Borrelia burgdorferi Reservoir Deer Vector Ticks Lyme Disease

10. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Lyme Disease Figure 23.13a

11. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Lyme Disease Figure 23.13b, c

12. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings First symptom bull's eye rash Second phase Irregular heartbeat, encephalitis Third phase Arthritis Lyme Disease Figure 23.14

13. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Ehrlichia, gram-negative, obligately intracellular (in white blood cells) Reservoir Deer, rodents Vector Ticks Ehrlichiosis Figure 23.15

14. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Epidemic typhus Rickettsia prowazekii Reservoir Rodents Vector Pediculus humanus corporis Transmitted when louse feces rubbed into bite wound Typhus

15. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Epidemic murine typhus Rickettsia typhi Reservoir Rodents Vector Xenopsylla cheopsis Typhus

16. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Rickettsia rickettsii Measles-like rash except that the rash appears on palms and soles too Spotted Fevers (Rocky Mountain spotted fever) Figure 23.18

17. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Spotted Fevers (Rocky Mountain spotted fever) Figure 23.16

18. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Tick Life Cycle Figure 23.17