National Institutes of Health K awards Margie Lee Dept Population Health BHSI Fellowship Writing Workshop Phase 1 – Feb 5, 2011

What is the NIHWhat is the NIH? Part of US Dept of Health and Human Services largest source of funding for medical research in the world Made up of 27 Institutes and Centers, each with a specific research agenda, often focusing on particular diseases or body system Spends > $31.2 billion annually in medical research – 80% goes to extramural

NIH Institutes National Cancer Institute (NCI) National Eye Institute (NEI) National Heart, Lung, and Blood Institute (NHLBI) National Human Genome Research Institute (NHGRI) National Institute on Aging (NIA) National Institute on Alcohol Abuse and Alcoholism (NIAAA) National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) National Institute of Biomedical Imaging and Bioengineering (NIBIB) National Institute of Child Health and Human Development (NICHD) National Institute on Deafness and Other Communication Disorders (NIDCD) National Institute of Dental and Craniofacial Research (NIDCR) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Institute on Drug Abuse (NIDA) National Institute of Environmental Health Sciences (NIEHS) National Institute of General Medical Sciences (NIGMS) National Institute of Mental Health (NIMH) National Institute on Minority Health and Health Disparities (NIMHD) National Institute of Neurological Disorders and Stroke (NINDS) National Institute of Nursing Research (NINR) National Library of Medicine (NLM) John E. Fogarty International Center for Advanced Study in the Health Sciences (FIC) National Center for Complementary and Alternative Medicine (NCCAM) National Center for Research Resources (NCRR)

Institute research can be very broad For example, National Institute of Diabetes and Digestive and Kidney Diseases 4 divisions: Diabetes, Endocrinology, and Metabolic Diseases; Digestive Diseases and Nutrition; Kidney, Urologic, and Hematologic Diseases; and Extramural Activities broad spectrum of metabolic diseases such as diabetes, obesity, inborn errors of metabolism, endocrine disorders, mineral metabolism, digestive and liver diseases, nutrition, urology and renal disease, and hematology. Basic research studies include biochemistry, biophysics, nutrition, pathology, histochemistry, bioorganic chemistry, physical chemistry, chemical and molecular biology, and pharmacology.

NIH Funding Opportunities Special Funding Opportunities Standard Research Grants Center and Facilities Grants Career Development Awards (most limited to US citizens or permanent residents)

Application Online PHS398 application using SF424 at Administrative forms Compliance documentation Biosketches Proposal content (limited to 12 pages) – Candidate's Background – Career Goals and Objectives – Career Development/Training Activities During Award Period – Training in the Responsible Conduct of Research Training in the Responsible Conduct of Research – Research Strategy – Animals, Human Subjects, Biohazards

Tools for finding NIH funding

Tools for finding NIH training support

K awardsK awards (postdoctoral) AwardInstitutefocus K01Multiple but agency specific eligibility & goals Mentored Research Scientist Development Award K02Multiple but agency specific eligibility & goals Independent Scientist Award K05NIAAA, NIDA, NCISenior Scientist Research and Mentorship Award K07Multiple but agency specific eligibility & goals Academic Career Award (teaching and research) K08Multiple but agency specific eligibility & goals Mentored Clinical Scientist Research Career Development Award (licensed MD, DVM, DDS)

K awardsK awards (postdoctoral) AwardInstitutefocus K18NIDCD, NHLBI, NCI, NIAAA, NIDDK, and NIEHS Varies – not mentored (Env health sci, stem cells, and other) K22Multiple but agency specific eligibility & goals Career Transition Awards (postdoc-> faculty) K23Multiple but agency specific eligibility & goals Mentored Patient-Oriented Research Career Development Award (MD, DDS) K25Multiple but agency specific eligibility & goals Mentored Quantitative Research Development Award K26NCRR, NIAMidcareer Investigator Award In Mouse Pathobiology Research K99/R00Multiple but agency specific eligibility & goals NIH Pathway to Independence Award (Parent K99/R00) no citizenship requirement

Which mechanism is right for you? Depends on the Institute that is most likely to be interested in funding your research Depends on your level (early in postdoc, transitioning to faculty position) Depends on research emphasis (basic or clinical) or clinical background

NCI K22 award facilitate the transition of investigators, primarily those with clinical doctoral degrees or doctoral degrees working in the areas of cancer prevention, control, behavioral, or population science research, from the mentored stage of career development in academic cancer research to the independent stage salary and research support for 3 years to: postdoctoral individuals or junior faculty in mentored positions transitioning into their first independent position; and investigators within the first 2 years of their first independent cancer research position

NIAID K22 award Will provide support for NIAID intramural and extramural post-doctoral fellows (working in NIAID funded labs or training grants) who are moving to Assistant Professor positions in an academic institution. 2 yr award, must have faculty position within 12 months of funding notification

K01 application (mentored) NIEHS - “protected time” for an intensive, supervised career development experience in occupational health and safety research leading to research independence. NIAID - protected time clinical research in the areas of epidemiology, modeling techniques, and/or outcomes research

K25 Award The purpose of the Mentored Quantitative Research Career Development Award (K25) is to attract to NIH- relevant research those investigators whose quantitative science and engineering research has thus far not been focused primarily on questions of health and disease. The K25 award will provide support and protected time for a period of supervised study and research for productive professionals with quantitative (e.g., mathematics, statistics, economics, computer science, imaging science, informatics, physics, chemistry) and engineering backgrounds to integrate their expertise with NIH-relevant research.

K08 award The K08 grant is a mentored training award for dentist, physician, and veterinary scientists who plan to become independent scientists. Eligibility: varies by Institute – Some require licensure – Most require strong research background – PhD is not required

K99/R00 NIH Pathway to Independence Award The award provides up to five years of support consisting of two phases. The initial award (K99) provides one to two years of mentored, postdoctoral support. The second phase (R00) provides up to three years of independent research support and is activated when the awardee accepts a full time tenure track (or equivalent) faculty position. No citizenship requirement Difficulty to acquire varies greatly by Institute

Allowable costs Salary and benefits Other costs vary by award type and Institute – Tuition – Research supplies – Travel – Indirect costs