1. U.S. Department of Health and Human Services National Institutes of Health National Heart, Lung, and Blood Institute James P. Kiley, Ph.D. National Heart, Lung, and Blood Institute Orientation to NIH May 21, 2005

2. National Institutes of Health Much of the biomedical research in the United States is supported by the Federal Government, primarily the National Institutes of Health (NIH)

3. Acquire new knowledge that will lead to better health for everyone Support research Train young investigators Communicate research results to the medical community and the public NIH Mission

4. 16% NIH In-House 6,000 Scientists $2.8 Intramural = 10% $1.0 RM&S = 4% $0.9 Other (NLM, OD, et al.) = 3% TOTAL BUDGET $28.8 Billion Spending Outside NIH $24.1 Spending at NIH $4.7 84% Outside NIH 212,000 Scientists & Other Personnel (Supports over 212,000 Scientists & Other Personnel) (Supports over 3,000 Institutions Nationwide) NIH comprises 27 Institutes and Centers FY 2005 Funding By Mechanism (dollars in billions)

5. National Institutes of Health Office of the Director National Human Genome Research Institute National Institute on Aging National Institute on Alcohol Abuse and Alcoholism National Institute of Allergy and Infectious Diseases National Institute of Arthritis and Musculoskeletal and Skin Diseases National Cancer Institute National Institute of Child Health and Human Development National Institute on Deafness and Other Communication Disorders National Institute of Biomedical Imaging and Bioengineering National Institute of Diabetes and Digestive and Kidney Diseases National Institute on Drug Abuse National Institute of Environmental Health Sciences National Eye Institute National Institute of General Medical Sciences National Heart, Lung, and Blood Institute National Institute of Mental Health National Institute of Neurological Disorders and Stroke National Institute of Nursing Research National Institute of Dental and Craniofacial Research

6. NIH Home Page - www.nih.gov NIH Guide Grant Policy Applications Additional Program Information Staff Contacts

7. NIH Extramural Programs GrantPatron (assistance, encouragement) CooperativePartner Agreement(assistance but substantial program involvement) ContractPurchaser (procurement)

8. Investigator-Initiated Research and Research Training Opportunities R01: Regular Research P01: Program Project SBIR: Small Business Innovative Research K-series: Career Awards NRSA: Fellowships and Training Grants

9. Opportunities for “Young” Investigators National Research Service Individual Fellowship (F32) Mentored Research Scientist Development Award (K01) Independent Scientist Award (K02) Mentored Clinical Scientist Development Award (K08) Small Grant (R03) Academic Research Enhancement Award (R15) Exploratory/Developmental Grant (R21) Loan Repayment Program (L30 and L40)

10. Identifies Career Goal and Prepares Application Submit Application IRG evaluates scientific merit Center for Scientific Review assigns application to Initial Review Group (IRG) and Institute Institute makes funding decision and issues Award Institute Advisory Council recommendation Manages Funds Training and Research Grantee Institution National Institutes of Health Investigator NIH Grant Process

11. PHS Research Grant Application Kit (form PHS 398) Application Kit (form PHS 398) Mail Completed Forms To: CENTER FOR SCIENTIFIC REVIEW NATIONAL INSTITUTES OF HEALTH ROCKLEDGE II ROOM 1040 MSC- 7710 BETHESDA MD 20892-7710 http://grants.nih.gov/grants/funding/phs398/phs398.html

12. Dual Review System for Grant Applications Second Level of Review Council  Assesses Quality of SRG  Review of Grant Applications  Makes Recommendation to  Institute Staff on Funding  Evaluates Program Priorities  and Relevance  Advises on Policy First Level of Review Scientific Review Group (SRG)  Provides Initial Scientific Merit  Review of Grant Applications  Rates Applications and Makes Recommendations for Appropriate Level of Support and Duration of Award

13. Receipt and Review Standard Receipt Dates for Competing Applications (http://grants2.nih.gov/grants/funding/submi ssionschedule.htm) Review Guidelines of Research Grants (http://www.csr.nih.gov/cdg/cd%20guidelines /r01_Research_Grants.pdf) NIH Grant Review Process Video (http://www.csr.nih.gov/video/video.asp)

14. Applications are Assigned to: Scientific review groups based on: –Specific review guidelines for each scientific review group –Applicants may indicate preference as to Institute and SRG assignment in cover letter Institutes based on: –Overall mission of the Institute and referral guidelines –Specific programmatic mandates and interests of the Institute

15. Review of Research Grants Review Criteria: –Significance –Approach –Innovation –Investigator –Environment –Overall Evaluation & Score Reflects Impact on Field

16. Scientific Review Group Actions Scored, Scientific Merit Rating (priority scores and percentiles) Unscored (lower half) Deferral

17. INSTITUTES FUND! STUDY SECTIONS DO NOT FUND

18. Research Training and Career Development

19. Postdoctoral Training Support (T32, F32) Research Training and Development Graduate Student Stages of Research Training and Development GraduateStudent Post- Doc. Career Mid-CareerChange Pre-doctoral Training Support (T32) SeniorFellowship(F33) Research Project Grant (R01)

20. Postdoctoral Training Support (T32, F32) Research Training and Development Medical Student Mentored Clinical Scientist Development Award (K08) Stages of Research Training and Development MedicalStudent Post-Doc. Career Mid-CareerChange Short-term Training of Health Professional Students (T35) InternshipResidency SeniorFellowship(F33) ResearchProject Grant (R01) (K24)(K23)

21. Institute-Initiated Research Targeted (<25% of extramural funds) Usually time-limited (4 yrs) unless re- announced Institute Specifies: Area of Research, Research Goals, Funds Allocated, Research Design, and Length of program (Program Announcements; Requests for Applications or Proposals)

22. Program Announcements (PAs) Invites grant applications in a given research area May describe new or expanded interest in a particular extramural program May be a reminder of a continuing interest in a particular extramural program Generally has no funds set aside Applications reviewed in CSR along with unsolicited grant applications

23. Requests for Applications (RFAs) Announcement describing an institute initiative in a well-defined scientific area Invitation to the field to submit research grant applications for a one-time competition Set-aside of funds for a certain number of awards Applications generally reviewed within the issuing institute

24. NIH Guide for Grants and Contracts

25. NHLBI Home Page – www.nhlbi.nih.gov