samedicino statistikis aqtualuri sakiTxebi marina kikviZe Tbilisi, tfdec 09.02.2010

mizani ganvixiloT samedicino statistikis ZiriTadi meTodebi; gavecnoT kvlevis Catarebis dros daSvebul Secdomebs.

samedicino statistika klinikuri kvlevis Sedegad miRebul monacemTa damuSavbis meTodia; kvlevis saSualebaa da ara Sedegi; klinikuri gamocdilebis gadayvana raodenobrivi Sefasebis enaze.

biostatistika da klinikuri praqtika samecniero kvlevis organizaciisa da Catarebis meTodologia samedicino literaturis swori wakiTxva

kvleva zedmiwevniT guldasmiT unda davgegmoT, xolo Sedegebi - sworad avxsnaT

klinikur monacemTa tipebi raodenobrivi (interval data) xarisxobrivi (nominal data) rigiTi (ordinal data)

normaluri ganawilebis mrudi ganawilebis tipebi normaluri ganawilebis mrudi 0 5 20 40 60 80 95 100 2.5 10 30 50 70 90 97.5 50 40 30 20 10 +/– 2 standartuli gadaxra +/–1 standartuli gadaxra monacemis mniSvneloba wili populaciaSi (%)

asimetriuli ganawilebis mrudebi ganawilebis tipebi asimetriuli ganawilebis mrudebi moda : yvelaze xSiri maCvenebeli mediana: wertili, romlis qvemoT da zemoT ganlagebulia maCvenebelebis zustad naxevari, anu 50% (procentili). saSualo: monacemTa jami  dakvirvebaTa ricxvi

statistikuri meTodebi monacemebis aRwera parametriuli (saSualo, standartuli gadaxra) araparametriuli (mediana, moda, procentilebi) hipoTezis Semowmeba

nulovani hipoTezis cneba nulovani hipoTeza (Ho) niSnavs daSvebas, rom sxvaoba or Sedarebul obieqts Soris ar aRiniSneba. Ho miReba niSnavs, rom dadgenili sxvaoba SemTxveviTia; Ho ar miReba ki piriqiT – sxvaoba ar aris SemTxveviTi. Ho SecdomiT uaryofis albaTobas ew. alfa-Secdoma / α-error. Ho SecdomiT miRebis albaTobas ew. beta-Secdoma / β-error.

sinamdvileSi hipoTeza: statistikuri Secdoma sinamdvileSi hipoTeza: (1) sworia (2) arasworia (1) miRebulia sworia β - Secdoma hipoTeza (2)uaryofilia α - Secdoma sworia

statistikuri simZlavre simZlavre = 1 - β-Secdoma rac ufro maRalia simZlavre, miT metia mkurnalobis meTodis upiratesobis dadgenis Sansi, Tu is arsebobs. Cveulebriv sazRvraven 80% simZlavres (zogjer 90%). simZlavre matulobs sakvlevi obieqtebis raodenobis gazrdiT.

monacemTa analizis tipiuri Secdomebi sistematikuri Secdoma Sansi kolinearnoba hipotezebis areva

sistematikuri Secdoma sakvlevi masalis SerCevis dros daSvebuli Secdoma - mkvlevari araobieqtiuria jgufebSi subieqtebis ganawilebis dros. gazomvis dros daSvebuli Secdomebi - erT jgufSi pacientebi ukeT sazRvraven mkurnalobis Sedegebs, vidre meoreSi. placebos efeqti - dadebiTi efeqti, rodesac pacienti fiqrobs, rom mas mkurnaloben

monacemTa analizis tipiuri Secdomebi Sansi - albaToba imisa, rom Sedegi miRebul iqna SemTxveviT; mag. р=0,05 niSnavs, rom SesaZlebelia erTi SemTxveviTi Sedegi 20-dan. kolinearnoba - faqtori, romelic dakavSirebulia obieqtTan da ara daavadebasTan; mag. filtvebis kiboTi daavadebulis jibeSi asanTis kolofi.

monacemTa analizis tipiuri Secdomebi hipotezebis areva - faqtori, romlis zemoqmedeba ar iyo gaTvaliswinebuli hipoTezis gansazRvrisas; mag. qlorvinilis zegavlena kiboTi daavadebis riskze qimiur mrewvelobaSi momuSaveTa Soris.

klinikuri kvlevebis klasifikacia observaciuli eqsperimentuli aRwerilobiTi analitikuri SemTxvevebis aRwera/Case reports SemTxvevaTa seriebis kvleva/Case series erTmomentiani kvleva gamokiTxvebi klinikuri cdebi /Clinical trials meta-analizi /Meta-analysis «SemTxveva-kontroli» /Case-control study kohortuli /Cohort study

kriteriumebi kvleva cvladi Oori jgufi or jgufze meti erTi jgufi mkurnalobamde da Semdeg erTi jgufi mkurnalobis ramdenime saxe cvladebis kavSiri raodenobrivi (normaluri ganawileba*) stiudentis Student(William Gosset ) kriteriumi dispersiu;li analizi stiudentis wyvili kriteriumi ganmeorebiTi gazomvebis dispersiu;li analizi wrfivi regresia, korelacia an blend-altmanis meTodi xarisxobrivi kriteriumi x² Kmak-nimaris kriteriumi Kkokrenis kriteriumi ...koeficienti rigiTi man-uitnis Mann-Whitney kriteriumi Kkruskal-uolisis Kruskall-Wallis kriteriumi uilkoksonis Wilcoxon kriteriumi Ffridmanis kriteriumi spirmenis rangebis korelaciis koeficienti sicocxlis xangrZlivoba Ggehanis kriteriumi *Tu ganawileba asimetriulia, iyeneben analogiur araparametriul meTodebs

sarwmunoebis ori koncefcia Sida sarwmunoeba internal validity ganisazRvreba imiT, Tu Catarebuli kvleviT miRebuli Sedegebi Seesabameba sinamdviles , anu is axasiaTebs mxolod avadmyofTa gamokvleul jgufs. gareTa sarwmunoeba (ganzogadoeba) external validity or generalizability ganisazRvreba imiT, Tu Catarebuli kvleviT miRebuli Sedegebi gamoyenebadia avadmyofTa sxva jgufze.

kompiuteruli teqnologiebi monacemTa analizisaTvis EpiInfo SNA - Social Network Analysis SPSS — Statistical Package for the Social Science

Social Network Analysis (SNA)

gmadlobT yuradRebisaTvis