DYSPEPSIA Leena Patel 1/2/12
OVERVIEW Statistics Red flags Management H-pylori testing and treatment
STATISTICS 5% of adults/year consult their GP for dyspepsia symptoms 1% will go on to have endoscopy Of these: 80% will have non-ulcer dyspepsia or reflux 13% will have a peptic ulcer <3% will have malignancy
SYMPTOMS Nausea Vomiting Bloating Belching Epigastric pain Retrosternal pain Early satiety Chronic cough
ALARM SYMPTOMS Progressive dysphagia Persistent vomiting Progressive unintentional weight loss Iron deficiency anaemia Epigastric mass Chronic GI bleeding Suspicious barium study
ENDOSCOPY Refer patient of ANY age with ≥1 of the above listed alarm symptoms Refer patients >55 years of age with new onset unexplained dyspepsia which is persistent (4-6 weeks) even without alarm symptoms TRY TO AVOID USING PPI/H2RA FOR 2 WEEKS PRIOR TO ENDOSCOPY
ENDOSCOPY RESULTS UPPER GI MALIGNANCY PEPTIC ULCER DISEASE (GASTRIC/DUODENAL) NON-ULCER DYSPEPSIA GORD WITH/WITHOUT OESOPHAGITIS
MANAGEMENT Divided into: Uninvestigated dyspepsia H-pylori eradication GORD, PUD, NUD
MEDICATION INDUCED NSAIDS Steroids Bisphosphonates Calcium channel blockers Nitrates Theophyllines
LIFESTYLE Healthy balanced diet Avoid/reduce fatty food, caffeine, chocolate Weight reduction Smoking cessation Reduce alcohol intake Avoid late meals Raise end of bed Try antacids/alginate therapy for intermittent symptoms
UNINVESTIGATED DYSPEPSIA H-pylori testing and treat with eradication/PPI OR Treat with high dose PPI for 1 month and then test for H-Pylori if still symptomatic NICE suggests either way is acceptable Both treatments equally effective and cost effective (BMJ 2008) Advises treat and test if still symptomatic
H-Pylori TESTING Carbon 13 urea breath test, stool antigen and serology Serology is less accurate but can be done whilst on a PPI Breath test and antigen test have similar and high sensitivity and specificity Before either breath/antigen test: Avoid antibiotics for 4 weeks Avoid PPI/H2RA for 2 weeks Patient should fast for 6 HOURS prior to breath test Avoid retesting due to high false positive, breath test if have to
ERADICATION REGIMES Standard triple therapy Full dose PPI + amoxicillin (1g BD) + clarithromycin (500mg BD) Full dose PPI + metronidazole (400mg BD) + clarithromycin (250mg BD) 7 day treatment 77% effective at eradication Sequential treatment 10 day treatment Full dose PPI Amoxicillin (1g BD) for the first 5d Metronidazole + clarithromycin (500mg BD) for next 5d 93% effective at H-pylori eradication
UNINVESTIGATED DYSPEPSIA If relapse following successful treatment, consider low dose PPI with regular review If symptoms fail to respond to PPI/eradication treatment, consider a trial of H2 receptor antagonist or prokinetic for 1 month and then review
GORD, NUD, PUD If peptic ulcer disease or non-ulcer disease on endoscopy, then test for H-Pylori and eradicate if present If GORD, or H-Pylori negative PUD or NUD, then 1-2 month course of PPI, doubling dose of PPI for 1month if not responding Consider 1 month trial of H2RA/prokinetic if still not responding Repeat endoscopy for H-Pylori positive GU.
Risks of long term PPI treatment Hip fractures and calcium malabsorption Vitamin B12 malabsorption Iron malabsorption Hypomagnesaemia Atrophic gastritis (esp. if H-pylori +ve) ?pneumonia
Summary Red flags Don’t forget medication induced dyspepsia, consider alternatives Lifestyle advice Regular review of PPI treatment due to potential risks of long term treatment