0 Where Science Means Business An Introduction to Yissum November 2007 Tami Kfir, VP Licensing Healthcare

1 The Hebrew University Of Jerusalem Over 1/3 of all academic scientific research In Israel 43% of Israel’s biotechnology research >1/3 of PhD students in Israel 4 Campuses 5 Affiliated Hospitals 24,000 Students 1,200 Researchers (Staff Members) 1,600 Post-Graduate Students in Biotechnology 320 Researchers in Applied Sciences

2 The Hebrew University of Jerusalem Mount Scopus Campus, Jerusalem

3 The Hebrew University of Jerusalem Edmond J. Safra Campus, Jerusalem Agriculture & Environmental Sciences Campus, Rehovot

4 The Hebrew University of Jerusalem Ein Kerem Campus, Jerusalem

5 Israel’s Top University  U of Texas for Institute of Higher Education, Shanghai Jiaotong University  Israel 12 th worldwide in academic research  Hebrew University no. 1 in Israel  60 th worldwide  Only Israeli university in top 100  Times Higher Education 2006  HU 63 rd worldwide in biomedicine  HU 52 nd worldwide in science  29 th worldwide ex-US, UK  Newsweek  Hebrew University 82 nd worldwide  Only Israeli university in top 100

6 A Nobel Heritage  2002 Nobel Prize in Economics  Daniel Kahneman, Princeton  2004 Nobel Prize in Physics  David J. Gross, UC Santa Barbara  2004 Nobel Prize in Chemistry  Avram Hershko, Technion  Aaron Ciechanover, Technion  2005 Nobel Prize in Economics  Robert J. Aumann, Hebrew University  2006 Nobel Prize in Chemistry  Roger Kornberg, Stanford

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8 Top 20 Most Frequently Cited Papers Stem Cells

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10 Biotech Nano- science Materials Computer Sciences Medicine Environment Homeland Security Agriculture A Broad Range of Technologies Computer Engineering

11 Yissum’s Mission To promote the transfer of Hebrew University technology for the benefit of society, while maximizing returns to support research, education and scientific excellence

12 Current Snapshot  $1 Billion annual sales of Hebrew University- based products  5,000 patents  1,400 inventions  400 licenses  60 spin-offs  Raised $150 mil in past year from leading VCs

13 A Record of Achievement  2006 revenues $40mil, up from $34mil in 2005  $29mil royalties  $11mil sponsored research & services  HU research budget $100mil  Ranked in top 15 worldwide (AUTM)  Leading US university royalties  MIT $35-40mil / year  Research budget: $1 Billion  Stanford $50-60 / year  Research budget: $900 Million

14 Board of Directors Business leaders Yissum Business-oriented organization Founded 1964 The Hebrew University Non-profit organization Where Science Means Business

15 Board of Directors Giora Yaron, PhD – Chairman Uri Banin, PhD Reuven Behar Hervé Bercovier, PhD S. Morry Blumenfeld, PhD Martin Gerstel Elhanan Hacohen Alex Keynan, PhD Amos Mar-Haim Hadar Ron, MD Moshe Vigdor Chairman, Mercury; founder, P-Cube, Exanet Hebrew University, Director Nanoscience Centre Managing Partner, FBC&Co.; chairman, Netafim Hebrew University, VP R&D VC, ex-CEO GE Medical, Israel Ex-CEO Alza; chairman, Compugen Hebrew University, VP & Director General Hebrew University, Prof. Emeritus Director, JDA; Ex-CEO Clal Industries Managing Director, Israel Healthcare Ventures Director General, Jewish Agency

16 Product-based Business-oriented Mission/project focused Confidentiality essential Timeframes & milestones Economic role Knowledge-based Curiosity-driven Broad scope Publications No time limits Educational role Industry vs. Academia The Challenge

17 Intellectual Property 2006 Snapshot  100 new inventions  72 new patent applications  58 new patents granted Intellectual Property at HU  Yissum owns all IP developed at HU  Researchers receive 40-60% of revenues 2006 New Inventions

18 Global Reach

19 Yissum’s Spin-offs Rav-Galai

20 Long Shelf Life & Cherry Tomatoes The world’s most popular cocktail hybrids for greenhouse production Prof. Nachum Kedar Prof. Haim Rabinowich Department of Field Crops, Vegetables and Genetics: Faculty of Agriculture, Food And Environmental Sciences The Hebrew University Rehovot Campus 2006 sales $70 million Success Stories - Tomatoes

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22 DOXIL ® Doxorubicin HCI liposome injection Alza’s Lead Product for Oncology Prof. Yechezkel Barenholz Department of Biochemistry Faculty of Medicine The Hebrew University Of Jerusalem 2006 sales $375 million Success Stories - Doxil

23 For Treatment of Alzheimer’s Disease and Dementia Prof. Marta Weinstock-Rosin Department of Pharmacology Faculty of Medicine The Hebrew University Of Jerusalem 2006 sales $525 million Success Stories - Exelon

Healthcare - Source of Innovations Faculty of Medicine School of Pharmacy School of Dental Medicine Faculty of Science Faculty of Agriculture l

Healthcare Technologies Scope  NCEs  New Uses  Drug Delivery  Medical devices  Diagnostics  Research tools

Markets CNS Dermatology Oncology Infectious Diseases Cardiovascular Respiratory diseases Metabolic Dianostic (biomarkers; Imaging, Bioinformatics) Devices mainly Therapeutics

World Wide Leaders in Drug Delivery Main Expertise: Liposomes Sustained release Transdermal Nasal Colonic Delivery Biodegradable - Polymer encapsulates microparticulate and nanoparticulate targetable drug delivery systems

World Wide Leaders in Drug Delivery  Yechezkel Barenholz  Simon Benita  Daniel Cohen  Abraham Domb  Michael Friedman  Nissim Garti  Chaim Gilon  Gershon Golomb  Avraham Hochberg  Amnon Hoffman  Philip Lazarovici  Shlomo Magdassi  Abraham Rubinstein  Elka Touitou  Itamar Wilner

Bio Park First in Israel Service & support from near by university and hospitals 10,000m 2 of research laboratories

Commercial Efforts  Friendly WebSite  Use of web – tools such as Pharma – Licensing  MiniPlans  Israeli Opportunities: Incubators; BioLine; Teva  Active marketing worldwide including Bio- Conferences  Networking

The TTM can help you manage your entire technology transfer or licensing office. It can help increase the effectiveness of your office without increasing size. Some of the benefits using the TTM include:  Increase the quality of your invention disclosure  Improve the financial management of your technology portfolio including connection to an external financial system (SAP)  Maximize license revenues through effective contract management  Improve contact with researchers in your organization allowing them external access to the system.  Expand marketing reach of your organization for your technologies by allowing easy export of the technologies to external databases including the website  Make powerful reports on the data for effective business management and follow up  Integrated with Office environment  Built with the most up to date technology TTM (Technology Transfer Management)

32 Thank you for your attention