Infection Tumors Grafts Specificity Memory “Tolerance“

Slides:



Advertisements
Similar presentations
Immunity and Vaccines Immune system Virus persistence Immunity / memory / vaccines Neutr. Ab: successful vaccines!
Advertisements

Immunity to Infectious Diseases
(mechanisms of defense against viral, parasitic and fungal infections)
Chapter 18 Vaccines Termed coined by Pasteur to honor Jenner’s work Vaccines are cost-effective uses of our immune system Dramatic reduction of –Diptheria.
IMMUNITY.
Immunity to Infectious Diseases BIOS 486A/586A K.J.Goodrum 2006.
Specific, non-specific defense and vaccines
Microbiology B.E Pruitt & Jane J. Stein AN INTRODUCTION EIGHTH EDITION TORTORA FUNKE CASE Chapter 17, part A Specific Defenses of the Host: The Immune.
CENTER FOR BIOLOGICAL SEQUENCE ANALYSIS Technical University of Denmark - DTU Department of systems biology Biopeople Tutorial 2011 Immunological Bioinformatics.
ADAPTIVE IMMUNITY *To adapt means to become suitable, and adaptive immunity can become “suitable” for and respond to almost any foreign antigen. *Adaptive.
Dr. Fang-Ping Huang Department of Pathology, Immunology Division, Room 216 Tel
Design of immune system Immune system Self/non-self recognition The state of protection from infectious disease 自我非我 Memory Acceptance vs rejection 疫苗.
Vaccination. NATURALLY ACQUIRED IMMUNITY Active: Acquired through contact with microorganisms (infection). Provides long term protection. Passive: Antibodies.
4c – Adaptive Immunity.
 The system that keeps us alive and healthy – we call it the immune system.  Pathogens – microorganisms that produce diseases in us. (Bacteria, viruses,
Innate Defenses External defense skin, etc.. pH=3-5.
Immune Cells Types of Immunity Human Defenses Proteins.
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings Chapter 14 Specific Immunity (adaptive immunity)
18.3 Viral Diseases KEY CONCEPT Some viral diseases can be prevented with vaccines.
HIV – FIV - LCMV Immune system + viruses Tricks of pers. V: T deletion / escape nAb delay / escape Re-encountered / persistent antigen maintains nAb (successful.
Adaptive Immunity: Specific Defenses of the host
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings PowerPoint ® Lecture Slide Presentation prepared by Christine L. Case Microbiology.
Julio A. Ramirez, MD, FACP Professor of Medicine Chief, Infectious Diseases University of Louisville Chief, Infectious Diseases Veterans Affairs Medical.
Acquiring Immunity Long Term Protection. Individual Activity (means no talking) Read Acquiring Specific Immunity at top of p317 of Biology 2.
17-1 Topics Principals of immunization Vaccines Immunizations.
Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Capitulo 22 Sistema inmune Farmacoterapia Dra. González.
INTRODUCTION TO IMMUNOLOGY CLS 245. The eradication of smallpox was a major success of immunotherapy.
Viruses A virus is a NON-Living particle made of DNA or RNA and a protein coat. Look at table 25-1 on p. 487 in text book. VERY small. ~ 0.001micron.
Basic Immunology The Immune system must have the ability to distinguish between self and non-self molecules Self Molecules- components of an organism’s.
Acquired immunity Expected learning:
 To know the historical perspective of immunology  To be familiar with the basic terminology and definitions of immunology  Cells of immune response.
Introduction to Immunology & Lymphoid System Immunology Unit Department of Pathology College of Medicine KSU.
Neonatal Immunology Kristina Abel, PhD CNPRC UC Davis How a Lymphomaniac views ( IL )lness.
1 Immune Defenses Against Disease Chapter 15 (innate immunity) Chapter 16 (adaptive/acquired immunity) Chapter 17 (passive vs active immunization – pp.
Immune and Lymphatic System Alex Henderson Alex Henderson Block4 Block4.
Immunology Continued Specific Defenses of the Immune System.
Aims State the normal functions of the immune system.
___________DEFENSES of the HOST: THE IMMUNE RESPONSE
DR.FATIMA ALKHALEDY M.B.Ch.B;F.I.C.M.S/C.M.
Making Vaccines. Effective Vaccines Have low levels of side effects or toxicity. Protect against exposure to natural, or wild forms of the pathogen. Should.
اختبارات التعادل المناعي:Neutralization Tests:
Vaccination. immunity adaptive natural active passive artificial active passive innate.
Ch 31 – Section 1 Immune system Protect body from pathogens ANY FOREIGN PROTEIN = antigens Examples  Bacteria  Viruses  Fungi  Protozoa (animal-like.
Vaccine; To be effective  Must stimulate as many of the body's defence mechanisms as possible.  It is not necessary to get 100% uptake of vaccine in.
Chapter 16 Immunizations and Immunity. Amazing Fact “An estimated 2.1 million people around the world died in 2002 of diseases preventable by widely used.
Page 1 Immunology Proteins —by Creative BioMart. Page 2 Immunology is a broad branch of biomedical science that covers the study of all aspects of the.
(Immunization / Vaccination)
Immune response Pathophysiology.
Principle of Immunization
IMMUNOLOGY AND THE IMMUNE SYSTEM
Introduction to Immunology & Lymphoid System
Introduction to Immunology & Lymphoid System
CLS 223.
Virus DHO chapter 14.
BASIC PRINCIPLES OF ADAPTIVE IMMUNITY AND IMMUNIZATION
Immunology Ch Microbiology.
LECTURE: Specific Immune System B Cells & T Cells
Immunology & Public Health
Genetics of Immunity: Part 2
Chapter 17 Immune response.
The lymphatic system and immunity
RESISTANCE OF THE BODY TO INFECTION
The Lymphatic System Pages
Virus.
Specific Defenses of the Host: The Immune Response
OUR IMMUNE SYSTEM.
Introduction to Immunology & Lymphoid System
Unit 7: Infectious Diseases
RESISTANCE OF THE BODY TO INFECTION
Presentation transcript:

Infection Tumors Grafts Specificity Memory “Tolerance“

IMMUNITY “innate resistance“ > 95 % Ab in eggs protective memory via Ab (vaccines) TB: no vaccine autoimmunity > 30 y, female > male 5:1

B cell – Ab responses local mucosal IgA no T / LN / Peyer Ag + LPS :IgM (no T H ) intact virus :IgM (no T H ) serotypes monomeric Ag : obligatory T H

glycoprotein: LCMV-GPglycoprotein:IND-G rLCMV/INDGrVSV/LCMV-GP reverse genetic glycoprotein exchange between LCMV and VSV LCMVVSV-IND glycoprotein: LCMV-GPglycoprotein:IND-G

Only VSVG expressing viruses induce a neutralizing antibody response

Immunological memory Quicker (earlier) Greater (better) responses Immunity Protection against disease by reinfection First infection kills host: No memory needed Host survives first infection: Memory not needed neither

No protection by Memory B cells but protection by immune serum in IFN-aBR _ / _ against VSV VSV IND immune spleen cells T+B LCMV immune spleen cells VSV IND Ab Anti-VSV neutr. AB < 1 : 40 < 1 : 2500 % Survivors 0 100

Maintenance of protection 1. Agent persists: TB, leprosy, HIV, HCV, LCMV Herpes viruses crippled: measles 2. Repetitive inf.: polio, bact. toxins 3. Antibody-antigen complex depots in lymph nodes and spleens

Vaccines Success pox, polio:IgG measles, mumps: IgA, IgG No success TB, leprosy, HIV: Ig + T cells

Poliomyelitis – age distribution in Massachusetts 1912 – 1952

Memory / Pregnant Female Academic: earlier + higher (AG –) Immune against cytopathic infections otherwise abortions / malformations MHC-incompatibility – offspring mother: imm. suppr. / offspr.: imm. incomp. Maternal antibodies attenuate acute infections physiological vaccinations (incl. malaria, eggs) Non-cytophatic infections transferred via placenta / at birth / after birth (LCMV, HCV, Herpes) Resistance via T cells:HIV, HTV, TB Lepr. slow "Emerging" infections

Exempl. Ignor. Protect. Infect. imm. Exhaust. deletion Papill. V perif. self Polio V Infl. TB, HBV, HIV HCV, LDV (HIV, LCMV) Peripheral solid organs Peripheral lymphatic organs Generalized hematogenic spread Imm. resp. Antigen dose Time of antigen availability (days) 7 >100

H. Hengartner A.Althage M.Bachmann Th.Kündig A.Ciurea U.Karrer L.Hunziker M.Recher D.Pinschewer C.de la Torre A.Ochsenbein B.Ludewig M.Pericin HP.Roost St.Freigang M.Martinic Th.Rülicke B.Odermatt M.Whitt

Feedback: Privacy Policy Feedback
Do Not Sell My Personal Information
About project: SlidePlayer Terms of Service

© 2024 SlidePlayer.com Inc. All rights reserved.