Ventricular Assist Devices Topics in Bioengineering

Increasing use of VADs as bridge to transplantation Klotz et al. (2008) Prog Biophys Mol Biol

Overview of VAD types Klotz et al. (2008) Prog Biophys Mol Biol;

The HeartMate II VAD Miller et al. (2007) NEJM. Figure 1 Griffith et al. (2001) Ann Thorac Surg. Figure 2

Flow visualization around inlet stator and rotor Griffith et al. (2001) Ann Thorac Surg. Figure 3

Tethered and untethered configurations Griffith et al. (2001) Ann Thorac Surg. Figures 4 and 5

Pressure-flow relationships for HeartMate II Griffith et al. (2001) Ann Thorac Surg. Figure 6

Baseline characteristics of the patients (1) Miller et al. (2007) NEJM. Table 1 Normal: 55-70%

Baseline characteristics of the patients (2) Miller et al. (2007) NEJM. Table 1 N N N N N H - renal H - liver N H – tissue breakdown, various

Baseline characteristics of the patients (3) Miller et al. (2007) NEJM. Table 1 Increase contraction Edema Hypertension Hypertension, HF Arrhythmia Arrhythmia, HF Hypertension Arrhythmia (ventricular) Anticoagulant

Blood clotting cascade

NYHA Heart Failure Class

Functional status and quality of life Miller et al. (2007) NEJM. Table 2

Functional status and quality of life Miller et al. (2007) NEJM. Table 2 Plot on graph?

Outcomes of the patients Miller et al. (2007) NEJM. Table 3

Outcomes of the patients Miller et al. (2007) NEJM. Figure 2

Adverse events in the study Miller et al. (2007) NEJM. Table 4

Adverse events in the study Miller et al. (2007) NEJM. Table 4

Testimony from a patient ouz093Us&feature=endscreen

Questions for discussion Is it worth the risk? What major issues still need to be addressed? What can BMEs do to improve VAD design? What about for other patient populations (eg, women and children)? Other thoughts, ideas, critiques? tricular_assist_device.html