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In vitro hemodynamic characterization of HeartMate II at 6000 rpm: Implications for weaning and recovery  Gengo Sunagawa, MD, Nicole Byram, BS, Jamshid.

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Presentation on theme: "In vitro hemodynamic characterization of HeartMate II at 6000 rpm: Implications for weaning and recovery  Gengo Sunagawa, MD, Nicole Byram, BS, Jamshid."— Presentation transcript:

1 In vitro hemodynamic characterization of HeartMate II at 6000 rpm: Implications for weaning and recovery  Gengo Sunagawa, MD, Nicole Byram, BS, Jamshid H. Karimov, MD, PhD, David J. Horvath, MSME, Nader Moazami, MD, Randall C. Starling, MD, MPH, Kiyotaka Fukamachi, MD, PhD  The Journal of Thoracic and Cardiovascular Surgery  Volume 150, Issue 2, Pages (August 2015) DOI: /j.jtcvs Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Schematic drawing and picture of the HMII device (Thoratec Corp, Pleasanton, Calif) and pneumatic pump circulatory loop used in the in vitro tests. F1, Flow probe 1 (total flow); F2, flow probe 2 (HMII flow); HMII, HeartMate II; R, systemic resistor. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Steady-state pressure-flow relationships. These measurements, which include published, estimated (predicted), and obtained data, are shown for the various pump speeds tested. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 Pump flows and pressure increase measurements in a mock loop. Flow and pressure data were compared among steady-state, normal heart function, and heart failure conditions. A, At 10,000 rpm. B, At 8000 rpm. C, At 6000 rpm. R2, Coefficient of determination. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

5 Figure 4 Pump flow. A, Pump flows in normal heart function were compared between 6000 rpm LVAD support and 10,000 rpm LVAD support. B, Pump flows at 6000 rpm LVAD support were compared between normal heart function and heart failure conditions. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

6 Figure 5 Pressure and flow. A, Hemodynamics (AoP and pump flow) in normal heart function were compared between 6000 rpm LVAD support and no LVAD support (LVAD clamped). B, Hemodynamics (AoP and pump flow) in heart failure were compared between 6000 rpm LVAD support and no LVAD support (LVAD clamped). AoP, Aortic pressure; LVAD, left ventricular assist device. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions

7 Pump flows at 6000 rpm LVAD support were compared between normal and heart failure conditions.
The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2015 The American Association for Thoracic Surgery Terms and Conditions


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