MTHFR: Impact of Nitrous Oxide Presenter: Benjamin Lynch, ND International Academy of Biological Dentistry and Medicine Conference Las Vegas, NV.

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Presentation transcript:

MTHFR: Impact of Nitrous Oxide Presenter: Benjamin Lynch, ND International Academy of Biological Dentistry and Medicine Conference Las Vegas, NV “Clinicians will be central to helping consumer-patients use genomic information to make health decisions.” – NEJM (c) 2014: Benjamin Lynch, ND

Disclaimer & Disclosures The information presented here is for informational and educational purposes only. Docere, Inc and Benjamin Lynch will not be liable for any direct, indirect, consequential, special, exemplary, or other damages arising from the use or misuse of any materials or information published. President and CEO of SeekingHealth.com, SeekingHealth.org and founder of MTHFR.Net (c) 2014: Benjamin Lynch, ND

(c) 2014: Benjamin Lynch, ND

(c) 2014: Benjamin Lynch, ND

Donating Methyl Groups Methylation Donating Methyl Groups CH3 (c) 2014: Benjamin Lynch, ND

Methylation is the process of controlled transfer of a methyl group (CH3) onto amino acids, proteins, enzymes, and DNA in every cell and tissue of the body . . . This process is one of the essential metabolic functions of the body and is catalyzed by a variety of enzymes. (c) 2014: Benjamin Lynch, ND http://www.hdri-usa.com/tests/methylation/

Methylation Functions of Methylation (some): Gene regulation: turn on/off genes via SAMe Biotransformation: glutathione production DNA base formation: uracil  thymine Neurotransmission Cell membrane: phosphatidylcholine and DHA to membranes Adenosine as metabolic fuel regulator (acetyl CoA vs lactate) Cell protection: NFKB expression to reduce TNF cytotoxicity (c) 2014: Benjamin Lynch, ND http://www.ncbi.nlm.nih.gov/pubmed/24224954

Methylation Methyl Donors – donate a methyl group - CH3 Methylcobalamin (B12) Methylfolate (Folate) Methionine Choline Glycine TMG DMG (c) 2014: Benjamin Lynch, ND

(c) 2014: Benjamin Lynch, ND

“SAM, a remarkably versatile molecule, is said to be second, only to ATP, in the number of enzymes that require it.” http://jn.nutrition.org/content/136/6/1636S.full.pdf (c) 2013: Benjamin Lynch, ND

(c) 2014: Benjamin Lynch, ND

MTHFR snp can reduce one type of cancer risk. Which one? (Methotrexate Site) (5-FU site) (c) 2014: Benjamin Lynch, ND

Nitrous Oxide Bad? (c) 2014: Benjamin Lynch, ND

“The effect is well known among anesthetists that nitrous oxide irreversibly inactivates cob(I)alamin, the active form of vitamin B12 essential for methionine-synthase activity in the brain and converts it to cob(II)alamin.” http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673605759742.pdf?id=aaaZMYMo1O9384ndqawFu (c) 2014: Benjamin Lynch, ND

Nitrous Oxide Effect (c) 2014: Benjamin Lynch, ND

Source: http://www. anesthesia-analgesia. org/content/105/1/83/F4

MTHFR

(c) 2014: Benjamin Lynch, ND

(c) 2014: Benjamin Lynch, ND

(c) 2014: Benjamin Lynch, ND

Who’s at Risk? Screening (c) 2014: Benjamin Lynch, ND

Approximately 45% of the population has 1 copy of the MTHFR C677T Who are at risk for MTHFR mutations? Prevalence of homozygous TT genotype (two 677C>T alleles) among newborns by area and ethnic background, ICBDMS 2003 Approximately 45% of the population has 1 copy of the MTHFR C677T Wilcken B et al. J Med Genet 2003;40:619-625 (c) 2014: Benjamin Lynch, ND

(c) 2014: Benjamin Lynch, ND

At-Risk Populations for Nitrous Oxide Oxidative Stress > Glutathione Deficiency and Cell Membrane Damage Inflammation > TNFa Pathogens > Candida, viral infxns, h pylori . . . Heavy Metals MTHFR MTR MTRR Low or high homocysteine Methionine deficiency SAMe deficiency B12 deficiency MTHF deficiency B2 deficiency B3 deficiency B6 deficiency Selenium deficiency Cysteine deficiency Glycine deficiency Glutamate deficiency (c) 2014: Benjamin Lynch, ND

H202 inhibits MTR and promotes CBS “…exposures to chemicals that cause significant depletion of glutathione may ultimately cause a depletion of vitamin B12. In an extreme situation of severely depleted GSH caused by a chemical exposure, typical physiological levels of vitamin B12 may be insufficient to ensure survival of the vitamin…” H202 inhibits MTR and promotes CBS (c) 2014: Benjamin Lynch, ND A new role for glutathione: protection of vitamin B12 from depletion by xenobiotics; and How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis

(c) 2014: Benjamin Lynch, ND

Tylenol/Acetaminophen Bad? (c) 2014: Benjamin Lynch, ND

Key Points to Take to the Clinic Varying degrees of negative impact Utilize other interventions to reduce anxiety Team care Screen with questionnaire (meds, genes, conditions, age . . .) Inform patients about the risk of nitrous oxide Support methylation prior to giving nitrous oxide – and after. (c) 2014: Benjamin Lynch, ND

(c) 2014: Benjamin Lynch, ND

Thank you Great ways to stay informed: Newsletter Available at www.MTHFR.net Facebook: https://www.facebook.com/drbenjaminlynch October 2013 Nutrigenomics Conference www.SeekingHealth.org March 2014 Nutrigenomics Conference – www.SeekingHealth.org Physician’s Forum for Collaboration – www.SeekingHealth.org (c) 2014: Benjamin Lynch, ND If our environment and diet are healthy – then the MTHFR SNP is not so significant.