NIR Sensor Technology-Spectroscopy Moving Grating-Scanning Monochromator AOTF MEMS FTIR Filter Photometer Fixed Grating-Diode Array

Acquisition Time FTNIR ~ 8 seconds AOTF~10 seconds NIR Diode Array~1 sec or less Scanning Monochromator~30 seconds 50 X 20 msecs = 1 sec In presentation by Martin Warman, Pfizer, Inc. at IFPAC 2004

Types of NIR Spectrometers Scanning Devices Moving Grating-Scanning Monochromator AOTF MEMS FTIR Non-Scanning Devices Filter Photometer Fixed Grating-Diode Array

An avenue to avoid interference and ambiguity Multiple-sensor detection (CCD’s, diode arrays) An avenue to avoid interference and ambiguity

Sample The Sample is Moving! For the following unit operations: Blending Coating Drying Granulation Roller Compaction On-Line Content Uniformity The Sample is Moving!

Resolution & Spectral Range How much resolution do you need? What are spectral signatures of the materials you are looking at typically in the NIR spectral range? What spectral range is adequate?

NIR Diode Array Specifications Standard InGaAs – 1.7 micron No of Pixels Spectral Range nm Resolution nm 128 900-1700 6.5 256* 3.25 512 1.6125 1024 0.8 * Most popular choice

NIR Diode Array Specifications Extended InGaAs – 2.2 micron No of Pixels Spectral Range nm Resolution nm 128 1100-2200 8.8 256* 4.4 512 2.2 1024** 1.1 * Most popular choice **Not readily available

Other Desirable Features Ruggedness Diode Array spectrometers have no moving parts Ease of use Low Maintenance

Unique Features of CDI NIRS Automated built in references for wavelength and amplitude, can add customer specific references Do not have to remove from vessel to do OQ, can be done on the fly, even during experiment Meets USP 1119 specifications-generates report Dual redundant light source All in one package, Class I Div II, EP available

Instrument Rating Pentagon Score: 0 = low; 5 = high Cost Robustness Index Ease of use Richness of data Speed of Acquisition fti 1998